A Case of Metastatic Colon Cancer Dramatically Affected by Anti-EGFR Antibody Therapy

Ryoma Yagi, Yoshifumi Shimada, Kohei Miura, Yosuke Tajima, Takuma Okamura, Masato Nakano, Hiroshi Ichikawa, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Toshifumi Wakai, Hitoshi Nogami, Satoshi Maruyama, Yasumasa Takii

Research output: Contribution to journalArticle

Abstract

RAS mutation is an established predictive biomarker of resistance to anti-epidermal growth factor receptor(EGFR)therapy in metastatic colorectal cancer. In addition, previous studies identified mutations in ERBB2, FGFR1, PDGFRA, BRAF, MAP2K1, PTEN, and PIK3CA as potential mechanisms of resistance to anti-EGFR therapy. Testing for these mutations might be necessary to determine eligibility for anti-EGFR therapy in patients with metastatic colorectal cancer. CancerPlex®is a nextgeneration sequencer for 413 cancer genes. An analysis panel includes genes that may be associated with resistance to anti- EGFR therapy. A 65-year-old man with unresectable rectal cancer, multiple lung metastases, and a bulky liver metastasis was evaluated for expression of genes associated with resistance to anti-EGFR. The analysis found that all genes indicating resistance were wild-type genes. Cetuximab monotherapy was administered after rectal resection, with dramatic shrinkage of the metastatic tumors. A more accurate selection of patients according to tumor genetic status using CancerPlex®might improve the risk-benefit profile of anti-EGFR therapy.

Original languageEnglish
Pages (from-to)1800-1802
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume43
Issue number12
Publication statusPublished - 01-11-2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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  • Cite this

    Yagi, R., Shimada, Y., Miura, K., Tajima, Y., Okamura, T., Nakano, M., Ichikawa, H., Nagahashi, M., Sakata, J., Kobayashi, T., Kameyama, H., Wakai, T., Nogami, H., Maruyama, S., & Takii, Y. (2016). A Case of Metastatic Colon Cancer Dramatically Affected by Anti-EGFR Antibody Therapy. Gan to kagaku ryoho. Cancer & chemotherapy, 43(12), 1800-1802.