A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease

Kayoko Hayashi, Shigeo Nakamura, Takashi Koshikawa, Kuniyoshi Kitoh, Koichi Koike, Hirokazu Komatsu, Makoto Kuroda, Masao Kasahara, Ryuzo Ueda, Taizan Suchi

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12 Citations (Scopus)

Abstract

We report a case of neural cell adhesion molecule (NCAM)-positive peripheral T-cell lymphoma (PTCL), pleomorphic, medium and large cell type according to the updated Kiel classification, which was associated with human T-cell lymphotrophic virus type 1 (HTLV-1). The patient showed an unusual involvement of the gastrointestinal tract forming a bulky mass during the course of his disease, and a relatively indolent clinical course for 53 months until death. Phenotypic analysis showed CD2+, CD3-, CD4+, CD5+, CD7+, CD8-, CD16-, CD56+, and CD57- phenotype. Human T-cell lymphotrophic virus type 1 antibody was detected by the enzyme-linked immunosorbent assay. The proviral integration of HTLV-1 and the monoclonal rearrangements of T-cell receptor beta and gamma genes also were confirmed in DNA extract from fresh material. This fact calls attention to NCAM as one of the potential factors playing a role in the localization and behavior of lymphomas even within the category of PTCL associated with HTLV-1, ie, adult T-cell leukemia/lymphoma (ATLL).

Original languageEnglish
Pages (from-to)1251-1253
Number of pages3
JournalHuman Pathology
Volume25
Issue number11
DOIs
Publication statusPublished - 11-1994

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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