A case of neuroendocrine carcinoma in the hepatic hilar lymph nodes concomitant with an adenocarcinoma of the gallbladder

Haruka Okada, Yoichiro Uchida, Naomi Matsuzaki, Toru Goto, Satoshi Nishimura, Akira Kurita, Takafumi Nishimura, Shujiro Yazumi, Hiroaki Terajima

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Neuroendocrine tumors (NETs) are rare especially in the gallbladder. They have not been elucidated in the pathogenesis, clinicopathological characteristics, and treatment options. Case presentation: We present a 76-year-old woman with a gallbladder tumor and hepatic hilar lymph node swelling. The lymph node biopsy demonstrated neuroendocrine carcinoma (NEC). We performed cholecystectomy, hepatic hilar lymphadenectomy, extrahepatic biliary duct resection, and hepaticojejunostomy prior to chemotherapy. Pathological examination revealed the gallbladder mass was an adenocarcinoma invading to the muscular layer without any NEC components, whereas the hepatic hilar lymph nodes were filled with high-grade NEC cells with negligible area of adenocarcinoma. The patient received general chemotherapy consisting of carboplatin and etoposide, but a recurrence in the para-aortic lymph nodes occurred 4 months after surgery. Conclusions: We report a rare case of NEC of the hepatic hilar lymph nodes that were concomitant with an adenocarcinoma of the gallbladder. High-grade NEC generally has an aggressive behavior and an optimal treatment strategy should be chosen for each patient.

Original languageEnglish
Article number284
JournalWorld Journal of Surgical Oncology
Volume14
Issue number1
DOIs
Publication statusPublished - 14-11-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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