@article{c6d7abf1e6e64b0c8940407432281c09,
title = "A Case of Non-24-Hour Sleep-Wake Rhythm Disorder Treated With a Low Dose of Ramelteon and Behavioral Education",
abstract = "Non-24-hour sleep-wake rhythm disorder (N24SWD) occurs when the intrinsic circadian pacemaker does not entrain (synchronize) to the 24-hour light/dark cycle. There is currently no established treatment for sighted patients with N24SWD. To the best of our knowledge, there have been very few reports on the efficacy of ramelteon administered to sighted patients with N24SWD. We report the case of a sighted patient with N24SWD whose free-running sleep-wake pattern recorded by actigraphy was stopped after the administration of a low dose of ramelteon combined with behavioral education.",
author = "Akiko Watanabe and Marina Hirose and Chiaki Arakawa and Nakao Iwata and Tsuyoshi Kitajima",
note = "Funding Information: University School of Medicine, Aichi, Japan. The patient provided written informed consent for this study. All authors have contributed to and have approved the final manuscript, and all agree with this submission to the Journal of Clinical Sleep Medicine. The use of ramelteon in this case is considered to be within the approved usage for insomnia in Japan, although the applied dosage of 1 mg in this case was lower than approved dosage (8 mg). Dr. Iwata has received research grants from Otsuka, GSK, Tanabe-Mitsubishi, Dainippon-Sumitomo, Eizai, Daiichisankyo, and has received personal fees from Eli Lilly, Janssen, Otsuka, Shionogi, GSK, Dainippon-Sumitomo, Astellas, Yoshitomi, Meiji, Novartis, and Pfizer. Dr. Kitajima has received research grants from Eizai, Takeda, MSD, and has received personal fees from Eizai, Tanabe-Mitsubishi, Otsuka, Takeda, Eli Lilly, MSD, Meiji, Yoshitomiyakuhin, Dainippon-Suimitomo, Fukuda, Shionogi, and Novo Nordisk. The other authors report no conflicts of interest.",
year = "2018",
month = jul,
day = "15",
doi = "10.5664/jcsm.7244",
language = "English",
volume = "14",
pages = "1265--1267",
journal = "Journal of Clinical Sleep Medicine",
issn = "1550-9389",
publisher = "American Academy of Sleep Medicine",
number = "7",
}