TY - JOUR
T1 - A Case of Para-Aortic Lymph Node Metastasis of Rectal Cancer Successfully Treated Using Multidisciplinary Therapy
AU - Hatanaka, Tomoki
AU - Otsuka, Koki
AU - Kimura, Toshimoto
AU - Hakozaki, Masanori
AU - Yaegashi, Mizunori
AU - Kamishima, Megumu
AU - Miyake, Takanori
AU - Takashimizu, Kiyoharu
AU - Sato, Kei
AU - Fujii, Hitoshi
AU - Matsuo, Teppei
AU - Takahara, Takeshi
AU - Akiyama, Yuji
AU - Iwaya, Takeshi
AU - Nitta, Hiroyuki
AU - Koeda, Keisuke
AU - Mizuno, Masaru
AU - Sasaki, Akira
PY - 2017/11/1
Y1 - 2017/11/1
N2 - A 66-year-old man diagnosed with rectal cancer underwent high anterior resection and received adjuvant chemotherapy (UFT plus UZEL). One year after the surgery, lung and para-aortic lymph node(PLN)metastases were identified. We chose mFOLFOX6 for first-line chemotherapy. After 7 courses, we changed the regimen to sLV5FU2 because of Grade 3 neuropathy. After 5 courses, to treat progressive disease(PD), we changed the regimen to FOLFIRI. Then, the patient had stable disease (SD), and surgical excision was performed for both lung and lymph node recurrence without adjuvant chemotherapy. Six years after the excision, a CT scan revealed PLNagain. We chose FOLFIRI plus cetuximab. After 9 courses, the lymph nodes decreased in size and there was no other recurrence; thus we performed resection. However, a third PLNrecurrence was identified 20 months after the resection. Chemotherapy has continued for 47 courses, and he has maintained SD for more than 2 years.
AB - A 66-year-old man diagnosed with rectal cancer underwent high anterior resection and received adjuvant chemotherapy (UFT plus UZEL). One year after the surgery, lung and para-aortic lymph node(PLN)metastases were identified. We chose mFOLFOX6 for first-line chemotherapy. After 7 courses, we changed the regimen to sLV5FU2 because of Grade 3 neuropathy. After 5 courses, to treat progressive disease(PD), we changed the regimen to FOLFIRI. Then, the patient had stable disease (SD), and surgical excision was performed for both lung and lymph node recurrence without adjuvant chemotherapy. Six years after the excision, a CT scan revealed PLNagain. We chose FOLFIRI plus cetuximab. After 9 courses, the lymph nodes decreased in size and there was no other recurrence; thus we performed resection. However, a third PLNrecurrence was identified 20 months after the resection. Chemotherapy has continued for 47 courses, and he has maintained SD for more than 2 years.
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M3 - Article
C2 - 29394719
AN - SCOPUS:85046474853
SN - 0385-0684
VL - 44
SP - 1613
EP - 1616
JO - Gan to kagaku ryoho. Cancer & chemotherapy
JF - Gan to kagaku ryoho. Cancer & chemotherapy
IS - 12
ER -
