A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab

Fumiaki Sugiura, Toshihisa Kojima, Takeshi Oguchi, Shirou Urata, Yukio Yuzawa, Akihiro Sakakibara, Hiroki Hayashi, Norihiro Nishimoto, Naoki Ishiguro

Research output: Contribution to journalArticle

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Abstract

We report a case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis (RA) who received tocilizumab. A 65-year-old woman with a 20-year history of RA participated in a tocilizumab clinical trial. She received a single dose of 8 mg/kg tocilizumab intravenously. The following day the patient started to experience numbness and purpura in all four extremities. The purpura of her left lower limb became necrotic, and a skin ulcer appeared 3 weeks later. Steroid-pulse treatment was initiated 12 weeks after tocilizumab administration, with the result that the numbness improved, and the skin ulcers showed complete epithelialization.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalModern Rheumatology
Volume19
Issue number2
DOIs
Publication statusPublished - 01-01-2009

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Skin Ulcer
Peripheral Nervous System Diseases
Rheumatoid Arthritis
Purpura
Hypesthesia
Lower Extremity
Extremities
Steroids
Clinical Trials
tocilizumab

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Sugiura, Fumiaki ; Kojima, Toshihisa ; Oguchi, Takeshi ; Urata, Shirou ; Yuzawa, Yukio ; Sakakibara, Akihiro ; Hayashi, Hiroki ; Nishimoto, Norihiro ; Ishiguro, Naoki. / A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab. In: Modern Rheumatology. 2009 ; Vol. 19, No. 2. pp. 199-203.
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A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab. / Sugiura, Fumiaki; Kojima, Toshihisa; Oguchi, Takeshi; Urata, Shirou; Yuzawa, Yukio; Sakakibara, Akihiro; Hayashi, Hiroki; Nishimoto, Norihiro; Ishiguro, Naoki.

In: Modern Rheumatology, Vol. 19, No. 2, 01.01.2009, p. 199-203.

Research output: Contribution to journalArticle

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