A case of POEMS syndrome showing elevated serum interleukin 6 and abnormal expression of interleukin 6 in the kidney

A. Fukatsu, Y. Ito, Yukio Yuzawa, F. Yoshida, M. Kato, K. Miyakawa, S. Matsuo

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A 46-year-old female presented with POEMS syndrome. Hemodialysis was initiated to control severe anasarca and declining renal function. Corticosteroids were effective in treating renal insufficiency and other symptoms. Serum interleukin 6 (IL-6) was elevated before the corticosteroid therapy but returned to the normal level under the therapy. Immunostaining for the kidney tissue obtained by a renal biopsy showed a diffuse distribution of IL-6 in the glomeruli; thus, in contrast to normal, IL-6 was detected not only in mesangial cells but also in endothelial cells. IL-6 was also distributed in capillaries in the interstitium. While these results suggest a pathogenic role of IL-6 in POEMS syndrome, other factors may be necessary for the full expression of symptoms. Furthermore, it is suggested that chronically stimulated glomerular endothelial cells are capable of producing IL-6.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalNephron
Volume62
Issue number1
DOIs
Publication statusPublished - 01-01-1992
Externally publishedYes

Fingerprint

POEMS Syndrome
Interleukin-6
Kidney
Serum
Adrenal Cortex Hormones
Endothelial Cells
Mesangial Cells
Renal Insufficiency
Renal Dialysis
Edema
Biopsy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Urology
  • Physiology (medical)

Cite this

Fukatsu, A. ; Ito, Y. ; Yuzawa, Yukio ; Yoshida, F. ; Kato, M. ; Miyakawa, K. ; Matsuo, S. / A case of POEMS syndrome showing elevated serum interleukin 6 and abnormal expression of interleukin 6 in the kidney. In: Nephron. 1992 ; Vol. 62, No. 1. pp. 47-51.
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A case of POEMS syndrome showing elevated serum interleukin 6 and abnormal expression of interleukin 6 in the kidney. / Fukatsu, A.; Ito, Y.; Yuzawa, Yukio; Yoshida, F.; Kato, M.; Miyakawa, K.; Matsuo, S.

In: Nephron, Vol. 62, No. 1, 01.01.1992, p. 47-51.

Research output: Contribution to journalArticle

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T1 - A case of POEMS syndrome showing elevated serum interleukin 6 and abnormal expression of interleukin 6 in the kidney

AU - Fukatsu, A.

AU - Ito, Y.

AU - Yuzawa, Yukio

AU - Yoshida, F.

AU - Kato, M.

AU - Miyakawa, K.

AU - Matsuo, S.

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AB - A 46-year-old female presented with POEMS syndrome. Hemodialysis was initiated to control severe anasarca and declining renal function. Corticosteroids were effective in treating renal insufficiency and other symptoms. Serum interleukin 6 (IL-6) was elevated before the corticosteroid therapy but returned to the normal level under the therapy. Immunostaining for the kidney tissue obtained by a renal biopsy showed a diffuse distribution of IL-6 in the glomeruli; thus, in contrast to normal, IL-6 was detected not only in mesangial cells but also in endothelial cells. IL-6 was also distributed in capillaries in the interstitium. While these results suggest a pathogenic role of IL-6 in POEMS syndrome, other factors may be necessary for the full expression of symptoms. Furthermore, it is suggested that chronically stimulated glomerular endothelial cells are capable of producing IL-6.

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