A case of primary amelanotic malignant melanoma of the female urethra

Takahiko Yoshii, Akio Horiguchi, Suguru Shirotake, Musashi Tobe, Shinsuke Tasaki, Masamichi Hayakawa, Makoto Sumitomo, Tomohiko Asano

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5 Citations (Scopus)


We report a rare case of primary amelanotic malignant melanoma of the female urethra. A 58-year-old female with complaint of nodule on the external urethral meatus was referred to our hospital. Pathological diagnosis of the biopsy specimen from the nodule was malignant melanoma. Computed tomography of the chest and abdomen as well as bone scan showed no evidence of metastasis. Sentinel biopsy from the inguinal lymph nodes revealed no metastasis. Thereafter, the patient underwent radical urethrectomy, whose limits of resection were the bulbocavernosal muscles bilaterally, the arch of the pubic symphysis anteriorly, the anterior vaginal wall posteriorly, and the urethra up to the level of the bladder neck superiorly. The histopathological diagnosis was amelanotic malignant melanoma of the urethra. The patient had received six cycles of DAV-Feron (dacarbazine, nimustine, vincristine, and interferon-β) in an adjuvant setting, and there is no sign of reccurence 25 months after operation.

Original languageEnglish
Pages (from-to)734-737
Number of pages4
JournalJapanese Journal of Urology
Issue number6
Publication statusPublished - 09-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Urology


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