TY - JOUR
T1 - A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells
T2 - Its evaluation by immunohistochemical and genetic analyses
AU - Saito, Ryoko
AU - Fujishima, Fumiyoshi
AU - Nakamura, Yasuhiro
AU - Hoshikawa, Yasushi
AU - Tominaga, Junya
AU - Taniuchi, Shinji
AU - Kasajima, Atsuko
AU - Watanabe, Mika
AU - Okada, Yoshinori
AU - Sasano, Hironobu
N1 - Publisher Copyright:
© 2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Tumors harboring osteoclast-like giant cells (OGCs) at extraosseous site are extremely rare. These rare tumors have been detected most frequently in the pancreas and few pulmonary tumors harboring OGCs have been previously reported. In addition, the genetic profiles of these tumors have remained virtually unknown. Therefore, we report a case of pulmonary adenocarcinoma harboring OGCs in which k-ras mutation and immunohistochemical study of proteins associated with OGCs were examined. The case was a 70-year-old man, who demonstrated a pulmonary mass associated with unusual radiological features. Histopathologically, three different cell types, mucinous adenocarcinoma cell, OGC and mononuclear cell were detected. OGCs were immunohistochemically negative for epithelial markers and positive for histiocytic markers but mononuclear cells were immunopositive for epithelial markers. In addition, both mononuclear and adenocarcinoma cells had the same k-ras mutation profiles and mononuclear cells were immunohistochemically positive for macrophage colony-stimulating factor (M-CSF), one of the factors associated with OGC differentiation. Therefore, mononuclear cells were considered to be derived from neoplastic epithelium and OGCs could represent non-neoplastic cells. In addition, M-CSF locally produced could promote the differentiation of OGCs.
AB - Tumors harboring osteoclast-like giant cells (OGCs) at extraosseous site are extremely rare. These rare tumors have been detected most frequently in the pancreas and few pulmonary tumors harboring OGCs have been previously reported. In addition, the genetic profiles of these tumors have remained virtually unknown. Therefore, we report a case of pulmonary adenocarcinoma harboring OGCs in which k-ras mutation and immunohistochemical study of proteins associated with OGCs were examined. The case was a 70-year-old man, who demonstrated a pulmonary mass associated with unusual radiological features. Histopathologically, three different cell types, mucinous adenocarcinoma cell, OGC and mononuclear cell were detected. OGCs were immunohistochemically negative for epithelial markers and positive for histiocytic markers but mononuclear cells were immunopositive for epithelial markers. In addition, both mononuclear and adenocarcinoma cells had the same k-ras mutation profiles and mononuclear cells were immunohistochemically positive for macrophage colony-stimulating factor (M-CSF), one of the factors associated with OGC differentiation. Therefore, mononuclear cells were considered to be derived from neoplastic epithelium and OGCs could represent non-neoplastic cells. In addition, M-CSF locally produced could promote the differentiation of OGCs.
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U2 - 10.1111/pin.12395
DO - 10.1111/pin.12395
M3 - Article
C2 - 26939759
AN - SCOPUS:84960192260
SN - 1320-5463
VL - 66
SP - 224
EP - 229
JO - Pathology International
JF - Pathology International
IS - 4
ER -