A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy

S. Kawabe, H. Takiuchi, I. Hirata, Y. Takao, K. Nakagawa, Y. Egashira, Y. Nakagawa, K. Katsu

Research output: Contribution to journalArticle

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Abstract

A 59-year old male patient had been operated on for sigmoid colon cancer in July, 1990. Operative findings were P 0, H 0, S 1, N (-), Stage I, and histological findings were ss, ly 2, v O, n (-). In July 1994, the CEA level elevated, and he was diagnosed as having para-aortic LN swelling and stenosis of anastomosis of colon. He was admitted for treatment of recurrent colon cancer. Initially, he was treated with continuous injection of 5-FU, low- dose CDDP and Leucovorin. His CEA level decreased and para-aortic LN diminished in size. But, in December 1995, the CEA level and para-aortic LN relapsed. 5-FU, CDDP and Leucovorin were administered, but the CEA level became more and more elevated. This regimen was not considered responsible for drug resistance. CPT-11 was administered at 60 mg/week 6 times, and 80 mg/week 3 times. The side effects disappeared, LN sightly diminished in size, and the CEA level decreased. Judging by the anticancer effect without severe side effect, we found CPT-11 a useful drug for second-line chemotherapy.

Original languageEnglish
Pages (from-to)1315-1319
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume24
Issue number10
Publication statusPublished - 24-09-1997
Externally publishedYes

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irinotecan
Leucovorin
Fluorouracil
Colonic Neoplasms
Sigmoid Neoplasms
Drug Therapy
Drug Resistance
Pathologic Constriction
Colon
Injections
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Pharmacology

Cite this

Kawabe, S., Takiuchi, H., Hirata, I., Takao, Y., Nakagawa, K., Egashira, Y., ... Katsu, K. (1997). A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy. Japanese Journal of Cancer and Chemotherapy, 24(10), 1315-1319.
Kawabe, S. ; Takiuchi, H. ; Hirata, I. ; Takao, Y. ; Nakagawa, K. ; Egashira, Y. ; Nakagawa, Y. ; Katsu, K. / A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy. In: Japanese Journal of Cancer and Chemotherapy. 1997 ; Vol. 24, No. 10. pp. 1315-1319.
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Kawabe, S, Takiuchi, H, Hirata, I, Takao, Y, Nakagawa, K, Egashira, Y, Nakagawa, Y & Katsu, K 1997, 'A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy', Japanese Journal of Cancer and Chemotherapy, vol. 24, no. 10, pp. 1315-1319.

A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy. / Kawabe, S.; Takiuchi, H.; Hirata, I.; Takao, Y.; Nakagawa, K.; Egashira, Y.; Nakagawa, Y.; Katsu, K.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 24, No. 10, 24.09.1997, p. 1315-1319.

Research output: Contribution to journalArticle

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AU - Katsu, K.

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Kawabe S, Takiuchi H, Hirata I, Takao Y, Nakagawa K, Egashira Y et al. A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy. Japanese Journal of Cancer and Chemotherapy. 1997 Sep 24;24(10):1315-1319.