A case of renal sarcoidosis showing central necrosis and abnormal expression of angiotensin converting enzyme in the granuloma

Y. Ito, T. Suzuki, M. Mizuno, Y. Morita, E. Muto, S. Ichida, M. Hananouchi, Yukio Yuzawa, S. Matsuo

Research output: Contribution to journalArticle

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Abstract

We describe a 66-year-old man who developed renal failure related to granulomatous renal sarcoidosis without systemic manifestations. Renal failure was severe enough to require hemodialysis transiently. Renal biopsy of this patient revealed the central necrosis of the granuloma which is usually absent in sarcoid granuloma. Serum level of angiotensin converting enzyme (ACE) was not helpful for diagnosis in this patient because serum ACE level is often elevated in the condition of chronic renal failure. Immunohistochemical detection of ACE was of diagnostic value in this patient. Subsequent course in which glucocorticoid was used for therapy was consistent with the diagnosis. This is the first report of identification of ACE in renal sarcoid granuloma.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalClinical nephrology
Volume42
Issue number5
Publication statusPublished - 01-01-1994

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Peptidyl-Dipeptidase A
Sarcoidosis
Granuloma
Necrosis
Kidney
Renal Insufficiency
Serum
Glucocorticoids
Chronic Kidney Failure
Renal Dialysis
Biopsy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Ito, Y., Suzuki, T., Mizuno, M., Morita, Y., Muto, E., Ichida, S., ... Matsuo, S. (1994). A case of renal sarcoidosis showing central necrosis and abnormal expression of angiotensin converting enzyme in the granuloma. Clinical nephrology, 42(5), 331-336.
Ito, Y. ; Suzuki, T. ; Mizuno, M. ; Morita, Y. ; Muto, E. ; Ichida, S. ; Hananouchi, M. ; Yuzawa, Yukio ; Matsuo, S. / A case of renal sarcoidosis showing central necrosis and abnormal expression of angiotensin converting enzyme in the granuloma. In: Clinical nephrology. 1994 ; Vol. 42, No. 5. pp. 331-336.
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Ito, Y, Suzuki, T, Mizuno, M, Morita, Y, Muto, E, Ichida, S, Hananouchi, M, Yuzawa, Y & Matsuo, S 1994, 'A case of renal sarcoidosis showing central necrosis and abnormal expression of angiotensin converting enzyme in the granuloma', Clinical nephrology, vol. 42, no. 5, pp. 331-336.

A case of renal sarcoidosis showing central necrosis and abnormal expression of angiotensin converting enzyme in the granuloma. / Ito, Y.; Suzuki, T.; Mizuno, M.; Morita, Y.; Muto, E.; Ichida, S.; Hananouchi, M.; Yuzawa, Yukio; Matsuo, S.

In: Clinical nephrology, Vol. 42, No. 5, 01.01.1994, p. 331-336.

Research output: Contribution to journalArticle

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T1 - A case of renal sarcoidosis showing central necrosis and abnormal expression of angiotensin converting enzyme in the granuloma

AU - Ito, Y.

AU - Suzuki, T.

AU - Mizuno, M.

AU - Morita, Y.

AU - Muto, E.

AU - Ichida, S.

AU - Hananouchi, M.

AU - Yuzawa, Yukio

AU - Matsuo, S.

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Y1 - 1994/1/1

N2 - We describe a 66-year-old man who developed renal failure related to granulomatous renal sarcoidosis without systemic manifestations. Renal failure was severe enough to require hemodialysis transiently. Renal biopsy of this patient revealed the central necrosis of the granuloma which is usually absent in sarcoid granuloma. Serum level of angiotensin converting enzyme (ACE) was not helpful for diagnosis in this patient because serum ACE level is often elevated in the condition of chronic renal failure. Immunohistochemical detection of ACE was of diagnostic value in this patient. Subsequent course in which glucocorticoid was used for therapy was consistent with the diagnosis. This is the first report of identification of ACE in renal sarcoid granuloma.

AB - We describe a 66-year-old man who developed renal failure related to granulomatous renal sarcoidosis without systemic manifestations. Renal failure was severe enough to require hemodialysis transiently. Renal biopsy of this patient revealed the central necrosis of the granuloma which is usually absent in sarcoid granuloma. Serum level of angiotensin converting enzyme (ACE) was not helpful for diagnosis in this patient because serum ACE level is often elevated in the condition of chronic renal failure. Immunohistochemical detection of ACE was of diagnostic value in this patient. Subsequent course in which glucocorticoid was used for therapy was consistent with the diagnosis. This is the first report of identification of ACE in renal sarcoid granuloma.

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