A Case of Resistance to Systemic Therapy in Hypermutation of Colorectal Cancer

Kana Tanaka; Yoshifumi Shimada; Yosuke Tajima; Saki Yamada; Shinnosuke Hotta; Mae Nakano; Masato Nakano; Hitoshi Kameyama; Kohei Miura; Hiroshi Ichikawa; Masayuki Nagahashi; Hitoshi Nogami; Satoshi Maruyama; Yasumasa Takii; Toshifumi Wakai

A Case of Resistance to Systemic Therapy in Hypermutation of Colorectal Cancer

Kana Tanaka
, Yoshifumi Shimada
, Yosuke Tajima
, Saki Yamada
, Shinnosuke Hotta
, Mae Nakano
, Masato Nakano
, Hitoshi Kameyama
, Kohei Miura
, Hiroshi Ichikawa
, Masayuki Nagahashi
, Hitoshi Nogami
, Satoshi Maruyama
, Yasumasa Takii
, Toshifumi Wakai

Gastrointestinal Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

A 78-year-old man was admitted with diarrhea. Colonoscopy and computed tomography(CT)revealed rectal cancer with multiple liver metastases. Low anterior resection was performed for local control. After the operation, 5 courses of mFOLFOX6 plus bevacizumab chemotherapy were administered as first-line systemic therapy, but CT showed progressive disease with liver metastases. After the first-line systemic therapy, 2 courses of FOLFIRI plus bevacizumab chemotherapy were performed as second-line systemic therapy, but CT also revealed progressive disease with liver metastases. We retrospectively performed comprehensive genomic sequencing with a 415-gene panel and found that the patient had a hypermutation subtype. Interestingly, the panel also revealed that he had mismatch-repair(MMR)deficiency with MSH2 mutation, which is reported as a possible cause of resistance to 5-fluorouracil in colorectal cancer.

Original language	English
Pages (from-to)	2476-2478
Number of pages	3
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
Volume	45
Issue number	13
Publication status	Published - 01-12-2018

All Science Journal Classification (ASJC) codes

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "A Case of Resistance to Systemic Therapy in Hypermutation of Colorectal Cancer",

abstract = "A 78-year-old man was admitted with diarrhea. Colonoscopy and computed tomography(CT)revealed rectal cancer with multiple liver metastases. Low anterior resection was performed for local control. After the operation, 5 courses of mFOLFOX6 plus bevacizumab chemotherapy were administered as first-line systemic therapy, but CT showed progressive disease with liver metastases. After the first-line systemic therapy, 2 courses of FOLFIRI plus bevacizumab chemotherapy were performed as second-line systemic therapy, but CT also revealed progressive disease with liver metastases. We retrospectively performed comprehensive genomic sequencing with a 415-gene panel and found that the patient had a hypermutation subtype. Interestingly, the panel also revealed that he had mismatch-repair(MMR)deficiency with MSH2 mutation, which is reported as a possible cause of resistance to 5-fluorouracil in colorectal cancer.",

author = "Kana Tanaka and Yoshifumi Shimada and Yosuke Tajima and Saki Yamada and Shinnosuke Hotta and Mae Nakano and Masato Nakano and Hitoshi Kameyama and Kohei Miura and Hiroshi Ichikawa and Masayuki Nagahashi and Hitoshi Nogami and Satoshi Maruyama and Yasumasa Takii and Toshifumi Wakai",

year = "2018",

month = dec,

day = "1",

language = "English",

volume = "45",

pages = "2476--2478",

journal = "Gan to kagaku ryoho. Cancer \& chemotherapy",

issn = "0385-0684",

publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

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}

TY - JOUR

T1 - A Case of Resistance to Systemic Therapy in Hypermutation of Colorectal Cancer

AU - Tanaka, Kana

AU - Shimada, Yoshifumi

AU - Tajima, Yosuke

AU - Yamada, Saki

AU - Hotta, Shinnosuke

AU - Nakano, Mae

AU - Nakano, Masato

AU - Kameyama, Hitoshi

AU - Miura, Kohei

AU - Ichikawa, Hiroshi

AU - Nagahashi, Masayuki

AU - Nogami, Hitoshi

AU - Maruyama, Satoshi

AU - Takii, Yasumasa

AU - Wakai, Toshifumi

PY - 2018/12/1

Y1 - 2018/12/1

N2 - A 78-year-old man was admitted with diarrhea. Colonoscopy and computed tomography(CT)revealed rectal cancer with multiple liver metastases. Low anterior resection was performed for local control. After the operation, 5 courses of mFOLFOX6 plus bevacizumab chemotherapy were administered as first-line systemic therapy, but CT showed progressive disease with liver metastases. After the first-line systemic therapy, 2 courses of FOLFIRI plus bevacizumab chemotherapy were performed as second-line systemic therapy, but CT also revealed progressive disease with liver metastases. We retrospectively performed comprehensive genomic sequencing with a 415-gene panel and found that the patient had a hypermutation subtype. Interestingly, the panel also revealed that he had mismatch-repair(MMR)deficiency with MSH2 mutation, which is reported as a possible cause of resistance to 5-fluorouracil in colorectal cancer.

AB - A 78-year-old man was admitted with diarrhea. Colonoscopy and computed tomography(CT)revealed rectal cancer with multiple liver metastases. Low anterior resection was performed for local control. After the operation, 5 courses of mFOLFOX6 plus bevacizumab chemotherapy were administered as first-line systemic therapy, but CT showed progressive disease with liver metastases. After the first-line systemic therapy, 2 courses of FOLFIRI plus bevacizumab chemotherapy were performed as second-line systemic therapy, but CT also revealed progressive disease with liver metastases. We retrospectively performed comprehensive genomic sequencing with a 415-gene panel and found that the patient had a hypermutation subtype. Interestingly, the panel also revealed that he had mismatch-repair(MMR)deficiency with MSH2 mutation, which is reported as a possible cause of resistance to 5-fluorouracil in colorectal cancer.

UR - https://www.scopus.com/pages/publications/85060565339

UR - https://www.scopus.com/pages/publications/85060565339#tab=citedBy

M3 - Article

C2 - 30692503

AN - SCOPUS:85060565339

SN - 0385-0684

VL - 45

SP - 2476

EP - 2478

JO - Gan to kagaku ryoho. Cancer & chemotherapy

JF - Gan to kagaku ryoho. Cancer & chemotherapy

IS - 13

ER -

A Case of Resistance to Systemic Therapy in Hypermutation of Colorectal Cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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