A Case of Solid-Pseudopapillary Neoplasm with 30-Year Follow-Up after Multidisciplinary Treatment for Postoperative Recurrence

A 59-year-old woman was diagnosed with solid-pseudopapillary neoplasm (SPN) based on histopathological findings after distal pancreatectomy for a large tumor in the pancreatic tail at the age of 39. Thereafter, recurrence occurred at ages 49 and 55, and tumor resection was performed each time. At age 58, the patient had another recurrence and was treated with chemotherapy. However, this was ineffective, and the patient underwent surgery for the fourth time the following year. At age 62, she had another recurrence and underwent a fifth surgery. At age 64, local recurrence and bone metastasis were detected, and the patient was treated with radiotherapy. After age 68, the patient was transferred to palliative care, and she died 30 years after the first operation, at the age of 69. We report this case as an extremely rare example of an SPN for which multiple surgeries, chemotherapy, radiotherapy and multidisciplinary treatment were performed for local recurrence and in which long-term follow-up was possible.