A Case of Systemic Capillary Leak Syndrome With Severe Cardiac Dysfunction After mRNA Vaccination for COVID-19

Takashi Araki; Ryota Morimoto; Ryota Ito; Takashi Mizutani; Yuki Kimura; Shingo Kazama; Hideo Oishi; Tasuku Kuwayama; Hiroaki Hiraiwa; Toru Kondo; Takahiro Okumura; Toyoaki Murohara

doi:10.1016/j.cjco.2022.03.008

A Case of Systemic Capillary Leak Syndrome With Severe Cardiac Dysfunction After mRNA Vaccination for COVID-19

Takashi Araki
, Ryota Morimoto
, Ryota Ito
, Takashi Mizutani
, Yuki Kimura
, Shingo Kazama
, Hideo Oishi
, Tasuku Kuwayama
, Hiroaki Hiraiwa
, Toru Kondo
, Takahiro Okumura
, Toyoaki Murohara

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A 53-year-old woman with no significant medical history developed cardiogenic shock 4 days after receiving the second dose of the COVID-19 mRNA vaccine (BNT162b2, Pfizer/BioNtech). The patient required extracorporeal membrane oxygenation and an Impella device. Based on significant hemoconcentration, decreased plasma protein levels, and pathologic findings in myocardial specimens, the patient was diagnosed with vaccination-induced fulminant systemic capillary leak syndrome (SCLS) with severe cardiac dysfunction. This case highlights that SCLS can occur after COVID-19 mRNA vaccination and may be associated with cardiac dysfunction. In patients with cardiogenic shock, hemoconcentration, and hypoalbuminemia after vaccination, SCLS should be considered.

Original language	English
Pages (from-to)	656-659
Number of pages	4
Journal	CJC Open
Volume	4
Issue number	7
DOIs	https://doi.org/10.1016/j.cjco.2022.03.008
Publication status	Published - 07-2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.cjco.2022.03.008

Cite this

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title = "A Case of Systemic Capillary Leak Syndrome With Severe Cardiac Dysfunction After mRNA Vaccination for COVID-19",

abstract = "A 53-year-old woman with no significant medical history developed cardiogenic shock 4 days after receiving the second dose of the COVID-19 mRNA vaccine (BNT162b2, Pfizer/BioNtech). The patient required extracorporeal membrane oxygenation and an Impella device. Based on significant hemoconcentration, decreased plasma protein levels, and pathologic findings in myocardial specimens, the patient was diagnosed with vaccination-induced fulminant systemic capillary leak syndrome (SCLS) with severe cardiac dysfunction. This case highlights that SCLS can occur after COVID-19 mRNA vaccination and may be associated with cardiac dysfunction. In patients with cardiogenic shock, hemoconcentration, and hypoalbuminemia after vaccination, SCLS should be considered.",

author = "Takashi Araki and Ryota Morimoto and Ryota Ito and Takashi Mizutani and Yuki Kimura and Shingo Kazama and Hideo Oishi and Tasuku Kuwayama and Hiroaki Hiraiwa and Toru Kondo and Takahiro Okumura and Toyoaki Murohara",

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year = "2022",

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doi = "10.1016/j.cjco.2022.03.008",

language = "English",

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T1 - A Case of Systemic Capillary Leak Syndrome With Severe Cardiac Dysfunction After mRNA Vaccination for COVID-19

AU - Araki, Takashi

AU - Morimoto, Ryota

AU - Ito, Ryota

AU - Mizutani, Takashi

AU - Kimura, Yuki

AU - Kazama, Shingo

AU - Oishi, Hideo

AU - Kuwayama, Tasuku

AU - Hiraiwa, Hiroaki

AU - Kondo, Toru

AU - Okumura, Takahiro

AU - Murohara, Toyoaki

PY - 2022/7

Y1 - 2022/7

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AB - A 53-year-old woman with no significant medical history developed cardiogenic shock 4 days after receiving the second dose of the COVID-19 mRNA vaccine (BNT162b2, Pfizer/BioNtech). The patient required extracorporeal membrane oxygenation and an Impella device. Based on significant hemoconcentration, decreased plasma protein levels, and pathologic findings in myocardial specimens, the patient was diagnosed with vaccination-induced fulminant systemic capillary leak syndrome (SCLS) with severe cardiac dysfunction. This case highlights that SCLS can occur after COVID-19 mRNA vaccination and may be associated with cardiac dysfunction. In patients with cardiogenic shock, hemoconcentration, and hypoalbuminemia after vaccination, SCLS should be considered.

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DO - 10.1016/j.cjco.2022.03.008

M3 - Article

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SN - 2589-790X

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A Case of Systemic Capillary Leak Syndrome With Severe Cardiac Dysfunction After mRNA Vaccination for COVID-19

Abstract

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