A case report of intestinal tuberculosis diagnosed by double balloon enteroscopy and interferon-γ assay

Takayoshi Fujita, Takafumi Ando, Osamu Watanabe, Osamu Maeda, Kazuhiro Ishiguro, Hironao Takahashi, Daisuke Ishikawa, Masaaki Minami, Motofusa Hasegawa, Naoki Omiya, Yasumasa Niwa, Shigeo Nakamura, Hidemi Goto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 58-year-old woman was admitted in June 2005 with a fever of unknown origin. She had right lower quadrant abdominal pain. CT scan showed a thickened distal ileum wall and mesenteric lymph node enlargement. The differential diagnosis included : Crohn's disease, intestinal tuberculosis, malignant lymphoma, and Yersinia enteritis. On double balloon enteroscopy (DBE), mucosal edema and multiple circular ulcers were found in the distal ileum. On biopsy, a dense infiltration of lymphoid cells and an epithelioid granuloma with Langhans giant cells were noted. The whole-blood interferon-γ assay done using the QuantifFERON ® -TB2 G test (QFT) was positive. Intestinal tuberculosis was diagnosed. The patient's symptoms improved after anti-tuberculous therapy with isoniazid, rifanpicin, pyrazinamide and ethambutol. DBE and QFT were useful for diagnosing small bowel tuberculosis.

Original languageEnglish
Pages (from-to)2846-2851
Number of pages6
JournalGASTROENTEROLOGICAL ENDOSCOPY
Volume49
Issue number11
Publication statusPublished - 01-11-2007

Fingerprint

Double-Balloon Enteroscopy
Interferons
Tuberculosis
Ileum
Langhans Giant Cells
Fever of Unknown Origin
Pyrazinamide
Yersinia
Ethambutol
Enteritis
Isoniazid
Granuloma
Crohn Disease
Abdominal Pain
Ulcer
Lymphoma
Edema
Differential Diagnosis
Lymph Nodes
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Fujita, T., Ando, T., Watanabe, O., Maeda, O., Ishiguro, K., Takahashi, H., ... Goto, H. (2007). A case report of intestinal tuberculosis diagnosed by double balloon enteroscopy and interferon-γ assay. GASTROENTEROLOGICAL ENDOSCOPY, 49(11), 2846-2851.
Fujita, Takayoshi ; Ando, Takafumi ; Watanabe, Osamu ; Maeda, Osamu ; Ishiguro, Kazuhiro ; Takahashi, Hironao ; Ishikawa, Daisuke ; Minami, Masaaki ; Hasegawa, Motofusa ; Omiya, Naoki ; Niwa, Yasumasa ; Nakamura, Shigeo ; Goto, Hidemi. / A case report of intestinal tuberculosis diagnosed by double balloon enteroscopy and interferon-γ assay. In: GASTROENTEROLOGICAL ENDOSCOPY. 2007 ; Vol. 49, No. 11. pp. 2846-2851.
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Fujita, T, Ando, T, Watanabe, O, Maeda, O, Ishiguro, K, Takahashi, H, Ishikawa, D, Minami, M, Hasegawa, M, Omiya, N, Niwa, Y, Nakamura, S & Goto, H 2007, 'A case report of intestinal tuberculosis diagnosed by double balloon enteroscopy and interferon-γ assay', GASTROENTEROLOGICAL ENDOSCOPY, vol. 49, no. 11, pp. 2846-2851.

A case report of intestinal tuberculosis diagnosed by double balloon enteroscopy and interferon-γ assay. / Fujita, Takayoshi; Ando, Takafumi; Watanabe, Osamu; Maeda, Osamu; Ishiguro, Kazuhiro; Takahashi, Hironao; Ishikawa, Daisuke; Minami, Masaaki; Hasegawa, Motofusa; Omiya, Naoki; Niwa, Yasumasa; Nakamura, Shigeo; Goto, Hidemi.

In: GASTROENTEROLOGICAL ENDOSCOPY, Vol. 49, No. 11, 01.11.2007, p. 2846-2851.

Research output: Contribution to journalArticle

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AU - Fujita, Takayoshi

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AU - Maeda, Osamu

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AU - Takahashi, Hironao

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AU - Omiya, Naoki

AU - Niwa, Yasumasa

AU - Nakamura, Shigeo

AU - Goto, Hidemi

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AB - A 58-year-old woman was admitted in June 2005 with a fever of unknown origin. She had right lower quadrant abdominal pain. CT scan showed a thickened distal ileum wall and mesenteric lymph node enlargement. The differential diagnosis included : Crohn's disease, intestinal tuberculosis, malignant lymphoma, and Yersinia enteritis. On double balloon enteroscopy (DBE), mucosal edema and multiple circular ulcers were found in the distal ileum. On biopsy, a dense infiltration of lymphoid cells and an epithelioid granuloma with Langhans giant cells were noted. The whole-blood interferon-γ assay done using the QuantifFERON ® -TB2 G test (QFT) was positive. Intestinal tuberculosis was diagnosed. The patient's symptoms improved after anti-tuberculous therapy with isoniazid, rifanpicin, pyrazinamide and ethambutol. DBE and QFT were useful for diagnosing small bowel tuberculosis.

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Fujita T, Ando T, Watanabe O, Maeda O, Ishiguro K, Takahashi H et al. A case report of intestinal tuberculosis diagnosed by double balloon enteroscopy and interferon-γ assay. GASTROENTEROLOGICAL ENDOSCOPY. 2007 Nov 1;49(11):2846-2851.