A comparative study of magnifying blue laser imaging and magnifying narrow-band imaging system for endoscopic diagnosis of Helicobacter pylori infection

Tomomitsu Tahara, Kazuya Takahama, Noriyuki Horiguchi, Dai Yoshida, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Naoki Omiya

Research output: Contribution to journalArticle

Abstract

Helicobacter pylori (Hp) infection is a major cause of gastric cancer. The use of proton-pump inhibitors, anti-platelet and anti-coagulant has become widespread in the clinic. Thus, it would be clinically useful to distinguish Hp-positive stomachs by endoscopic findings alone. Blue laser imaging (BLI) is a new image-enhanced endoscopy technique that utilizes a laser light source developed for narrow-band light observation. We investigated the diagnostic ability of magnifying BLI endoscopy to distinguish Hp-positive stomach in cancer free subjects. The data were also compared to the diagnostic ability of magnifying narrow-band imaging (NBI) endoscopy. In total, 215 participants were randomly assigned to the NBI (n=112) and BLI (n=113) groups. The greater curvature of the gastric middle and upper corpus were carefully evaluated with magnifying NBI or BLI. Small, round pits, accompanied with regular honeycomb-like subepithelial capillary networks (SECNs), being regularly interspersed with collecting venules were considered as Hp infection negative, while enlarged or elongated pits with unclear SECNs or dense fine irregular vessels were considered as Hp infection positive. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the diagnosis of Hp infection for the NBI group was 0.97, 0.81, 0.87 and 0.95, respectively. Sensitivity, specificity, PPV and NPV for the BLI group was 0.98, 0.92, 0.93 and 0.98, respectively. There was no significant difference among the values for the NBI and BLI groups (all P>0.2). In conclusion, the diagnostic ability of magnifying BLI is acceptable, since it is similar to that of magnifying NBI.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalBiomedical Reports
Volume7
Issue number3
DOIs
Publication statusPublished - 01-01-2017

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Narrow Band Imaging
Helicobacter Infections
Helicobacter pylori
Imaging systems
Lasers
Imaging techniques
Endoscopy
Stomach Neoplasms
Stomach
Light
Sensitivity and Specificity
Coagulants
Venules
Proton Pump Inhibitors
Blood Platelets
Observation
Platelets

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Tahara, Tomomitsu ; Takahama, Kazuya ; Horiguchi, Noriyuki ; Yoshida, Dai ; Kawamura, Tomohiko ; Okubo, Masaaki ; Ishizuka, Takamitsu ; Nagasaka, Mitsuo ; Nakagawa, Yoshihito ; Shibata, Tomoyuki ; Omiya, Naoki. / A comparative study of magnifying blue laser imaging and magnifying narrow-band imaging system for endoscopic diagnosis of Helicobacter pylori infection. In: Biomedical Reports. 2017 ; Vol. 7, No. 3. pp. 236-240.
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A comparative study of magnifying blue laser imaging and magnifying narrow-band imaging system for endoscopic diagnosis of Helicobacter pylori infection. / Tahara, Tomomitsu; Takahama, Kazuya; Horiguchi, Noriyuki; Yoshida, Dai; Kawamura, Tomohiko; Okubo, Masaaki; Ishizuka, Takamitsu; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Shibata, Tomoyuki; Omiya, Naoki.

In: Biomedical Reports, Vol. 7, No. 3, 01.01.2017, p. 236-240.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A comparative study of magnifying blue laser imaging and magnifying narrow-band imaging system for endoscopic diagnosis of Helicobacter pylori infection

AU - Tahara, Tomomitsu

AU - Takahama, Kazuya

AU - Horiguchi, Noriyuki

AU - Yoshida, Dai

AU - Kawamura, Tomohiko

AU - Okubo, Masaaki

AU - Ishizuka, Takamitsu

AU - Nagasaka, Mitsuo

AU - Nakagawa, Yoshihito

AU - Shibata, Tomoyuki

AU - Omiya, Naoki

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N2 - Helicobacter pylori (Hp) infection is a major cause of gastric cancer. The use of proton-pump inhibitors, anti-platelet and anti-coagulant has become widespread in the clinic. Thus, it would be clinically useful to distinguish Hp-positive stomachs by endoscopic findings alone. Blue laser imaging (BLI) is a new image-enhanced endoscopy technique that utilizes a laser light source developed for narrow-band light observation. We investigated the diagnostic ability of magnifying BLI endoscopy to distinguish Hp-positive stomach in cancer free subjects. The data were also compared to the diagnostic ability of magnifying narrow-band imaging (NBI) endoscopy. In total, 215 participants were randomly assigned to the NBI (n=112) and BLI (n=113) groups. The greater curvature of the gastric middle and upper corpus were carefully evaluated with magnifying NBI or BLI. Small, round pits, accompanied with regular honeycomb-like subepithelial capillary networks (SECNs), being regularly interspersed with collecting venules were considered as Hp infection negative, while enlarged or elongated pits with unclear SECNs or dense fine irregular vessels were considered as Hp infection positive. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the diagnosis of Hp infection for the NBI group was 0.97, 0.81, 0.87 and 0.95, respectively. Sensitivity, specificity, PPV and NPV for the BLI group was 0.98, 0.92, 0.93 and 0.98, respectively. There was no significant difference among the values for the NBI and BLI groups (all P>0.2). In conclusion, the diagnostic ability of magnifying BLI is acceptable, since it is similar to that of magnifying NBI.

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