A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia

Hideaki Wakita, Hidekazu Tomimoto, Ichiro Akiguchi, Jin Xi Lin, Katsuichi Miyamoto, Nobuyuki Oka

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.

Original languageEnglish
Pages (from-to)1461-1465
Number of pages5
JournalNeuroReport
Volume10
Issue number7
DOIs
Publication statusPublished - 14-05-1999

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nimesulide
Cyclooxygenase 2 Inhibitors
Brain Ischemia
Microglia
Cerebrovascular Disorders
Histocompatibility Antigens
Common Carotid Artery
Major Histocompatibility Complex
Ligation
Serum
White Matter

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Wakita, Hideaki ; Tomimoto, Hidekazu ; Akiguchi, Ichiro ; Lin, Jin Xi ; Miyamoto, Katsuichi ; Oka, Nobuyuki. / A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia. In: NeuroReport. 1999 ; Vol. 10, No. 7. pp. 1461-1465.
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A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia. / Wakita, Hideaki; Tomimoto, Hidekazu; Akiguchi, Ichiro; Lin, Jin Xi; Miyamoto, Katsuichi; Oka, Nobuyuki.

In: NeuroReport, Vol. 10, No. 7, 14.05.1999, p. 1461-1465.

Research output: Contribution to journalArticle

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AU - Wakita, Hideaki

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AU - Oka, Nobuyuki

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