Abstract
The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1461-1465 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 10 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 14-05-1999 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia. / Wakita, Hideaki; Tomimoto, Hidekazu; Akiguchi, Ichiro; Lin, Jin Xi; Miyamoto, Katsuichi; Oka, Nobuyuki.
In: NeuroReport, Vol. 10, No. 7, 14.05.1999, p. 1461-1465.Research output: Contribution to journal › Article
TY - JOUR
T1 - A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia
AU - Wakita, Hideaki
AU - Tomimoto, Hidekazu
AU - Akiguchi, Ichiro
AU - Lin, Jin Xi
AU - Miyamoto, Katsuichi
AU - Oka, Nobuyuki
PY - 1999/5/14
Y1 - 1999/5/14
N2 - The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.
AB - The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.
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U2 - 10.1097/00001756-199905140-00013
DO - 10.1097/00001756-199905140-00013
M3 - Article
VL - 10
SP - 1461
EP - 1465
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 7
ER -