A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia

Hideaki Wakita; Hidekazu Tomimoto; Ichiro Akiguchi; Jin Xi Lin; Katsuichi Miyamoto; Nobuyuki Oka

doi:10.1097/00001756-199905140-00013

A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia

Hideaki Wakita, Hidekazu Tomimoto, Ichiro Akiguchi, Jin Xi Lin, Katsuichi Miyamoto, Nobuyuki Oka

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.

Original language	English
Pages (from-to)	1461-1465
Number of pages	5
Journal	Neuroreport
Volume	10
Issue number	7
DOIs	https://doi.org/10.1097/00001756-199905140-00013
Publication status	Published - 14-05-1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

Access to Document

10.1097/00001756-199905140-00013

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title = "A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia",

abstract = "The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.",

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T1 - A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia

AU - Wakita, Hideaki

AU - Tomimoto, Hidekazu

AU - Akiguchi, Ichiro

AU - Lin, Jin Xi

AU - Miyamoto, Katsuichi

AU - Oka, Nobuyuki

PY - 1999/5/14

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N2 - The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.

AB - The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.

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