A Dirofilaria immitis polyprotein up-regulates nitric oxide production

Hiroyuki Tezuka, Shinjiro Imai, Setsuko Tsukidate, Koichiro Fujita

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages,. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40-/-, mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.

Original languageEnglish
Pages (from-to)5283-5286
Number of pages4
JournalInfection and Immunity
Issue number9
Publication statusPublished - 09-2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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