A discrepancy between plasma glycated albumin and HbA1c levels in a patient with steroid-induced diabetes mellitus

Katsumi Iizuka; Takehiro Kato; Masami Mizuno; Jun Takeda

doi:10.1136/bcr-2016-214788

A discrepancy between plasma glycated albumin and HbA1c levels in a patient with steroid-induced diabetes mellitus

Katsumi Iizuka, Takehiro Kato, Masami Mizuno, Jun Takeda

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 57-year-old man was admitted for the treatment of steroid-induced diabetes mellitus (DM). He also had interstitial pneumonia and, to treat it, 20 mg prednisolone had been started in April 2014. Although glycated haemoglobin (HbA1c) level was 7.8% (62 mmol/mol), his glycated albumin (GA) level was normal (13.9%) and the ratio of GA to HbA1c (GA: HbA1c) was lower than that of normal participants and patients with type 2 DM. Plasma GA and GA:HbA1c levels became persistently lower. In September 2015, HbA1c levels measured by HPLC and immunoprecipitation methods were almost the same (6.8% (51 mmol/mol) and 6.7% (50 mmol/mol), respectively), but GA (10.2%) and GA:HbA1c (1.6) were much lower. We report the case of a patient with DM where steroid administration may have caused a decrease in plasma GA and GA:HbA1c levels via increased albumin turnover.

Original language	English
Article number	214788
Journal	BMJ Case Reports
Volume	2016
DOIs	https://doi.org/10.1136/bcr-2016-214788
Publication status	Published - 09-03-2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bcr-2016-214788

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title = "A discrepancy between plasma glycated albumin and HbA1c levels in a patient with steroid-induced diabetes mellitus",

abstract = "A 57-year-old man was admitted for the treatment of steroid-induced diabetes mellitus (DM). He also had interstitial pneumonia and, to treat it, 20 mg prednisolone had been started in April 2014. Although glycated haemoglobin (HbA1c) level was 7.8% (62 mmol/mol), his glycated albumin (GA) level was normal (13.9%) and the ratio of GA to HbA1c (GA: HbA1c) was lower than that of normal participants and patients with type 2 DM. Plasma GA and GA:HbA1c levels became persistently lower. In September 2015, HbA1c levels measured by HPLC and immunoprecipitation methods were almost the same (6.8% (51 mmol/mol) and 6.7% (50 mmol/mol), respectively), but GA (10.2%) and GA:HbA1c (1.6) were much lower. We report the case of a patient with DM where steroid administration may have caused a decrease in plasma GA and GA:HbA1c levels via increased albumin turnover.",

author = "Katsumi Iizuka and Takehiro Kato and Masami Mizuno and Jun Takeda",

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T1 - A discrepancy between plasma glycated albumin and HbA1c levels in a patient with steroid-induced diabetes mellitus

AU - Iizuka, Katsumi

AU - Kato, Takehiro

AU - Mizuno, Masami

AU - Takeda, Jun

PY - 2016/3/9

Y1 - 2016/3/9

N2 - A 57-year-old man was admitted for the treatment of steroid-induced diabetes mellitus (DM). He also had interstitial pneumonia and, to treat it, 20 mg prednisolone had been started in April 2014. Although glycated haemoglobin (HbA1c) level was 7.8% (62 mmol/mol), his glycated albumin (GA) level was normal (13.9%) and the ratio of GA to HbA1c (GA: HbA1c) was lower than that of normal participants and patients with type 2 DM. Plasma GA and GA:HbA1c levels became persistently lower. In September 2015, HbA1c levels measured by HPLC and immunoprecipitation methods were almost the same (6.8% (51 mmol/mol) and 6.7% (50 mmol/mol), respectively), but GA (10.2%) and GA:HbA1c (1.6) were much lower. We report the case of a patient with DM where steroid administration may have caused a decrease in plasma GA and GA:HbA1c levels via increased albumin turnover.

AB - A 57-year-old man was admitted for the treatment of steroid-induced diabetes mellitus (DM). He also had interstitial pneumonia and, to treat it, 20 mg prednisolone had been started in April 2014. Although glycated haemoglobin (HbA1c) level was 7.8% (62 mmol/mol), his glycated albumin (GA) level was normal (13.9%) and the ratio of GA to HbA1c (GA: HbA1c) was lower than that of normal participants and patients with type 2 DM. Plasma GA and GA:HbA1c levels became persistently lower. In September 2015, HbA1c levels measured by HPLC and immunoprecipitation methods were almost the same (6.8% (51 mmol/mol) and 6.7% (50 mmol/mol), respectively), but GA (10.2%) and GA:HbA1c (1.6) were much lower. We report the case of a patient with DM where steroid administration may have caused a decrease in plasma GA and GA:HbA1c levels via increased albumin turnover.

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A discrepancy between plasma glycated albumin and HbA1c levels in a patient with steroid-induced diabetes mellitus

Abstract

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