A failed case to diagnose cardiac sarcoidosis presenting advanced atrioventricular block

Mako Morikawa, Kimihiko Kato, Nobuo Kako, Shinya Hiramitsu, Mitsutoshi Oguri, Kazuhiro Yajima, Takeshi Hibino, Yasuchika Kato, Yoshikazu Mizoguchi, Makoto Kuroda, Kiyoshi Yokoi, Shin Ichiro Morimoto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A 53-year-old-male developed atrioventricular block in January 2001. A chest X-ray and laboratory tests, including serum angiotensin converting enzyme, were normal. The patient underwent permanent pacemaker implantation and attended for semiannual follow-up after discharge since the etiology of advanced atrioventricular block remains unknown. One year later, the patient was diagnosed with uveitis related to sarcoidosis. No clinical finding specific to cardiac sarcoidosis was notable at that time. Four years after onset, the patient developed congestive heart failure. An echocardiogram revealed diffuse LV hypokinesis, but no asymmetric interventricular septal thinning. Laboratory tests showed normal angiotensin converting enzyme. Noncaseating granuloma was not confirmed by transbronchial biopsy. Despite normal myocardial uptake of gallium-67, uptake of 18F-Fluorodeoxyglucose increased in the myocardium. Nevertheless, clinical manifestations did not match the criteria for cardiac sarcoidosis. Prednisolone was administered daily. Two months after tapering dosage, the patient developed multiple organ failure and died. Post mortem histological findings were consistent with cardiac sarcoidosis. We experienced great difficulty in detecting cardiac involvement in the early stage of sarcoidosis. A specific method with greater sensitivity is required to diagnose cardiac involvement in the early stages of sarcoidosis.

Original languageEnglish
Pages (from-to)e46-e49
JournalInternational Journal of Cardiology
Issue number2
Publication statusPublished - 26-09-2008

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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