A fatal case of metformin-associated lactic acidosis

Toshikazu Ozeki; Rui Kawato; Mitsuru Watanabe; Shun Minatoguchi; Yukari Murai; Akihiro Ryuge; Koji Takasugi; Takuya Hamada; Yukako Oyama; Atsushi Nomura; Tatsuhito Tomino; Hideaki Shimizu; Yoshiro Fujita

doi:10.2169/internalmedicine.55.5415

A fatal case of metformin-associated lactic acidosis

Toshikazu Ozeki, Rui Kawato, Mitsuru Watanabe, Shun Minatoguchi, Yukari Murai, Akihiro Ryuge, Koji Takasugi, Takuya Hamada, Yukako Oyama, Atsushi Nomura, Tatsuhito Tomino, Hideaki Shimizu, Yoshiro Fujita

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A 72-year-old woman with a history of type 2 diabetes mellitus was brought to the ER with metforminassociated lactic acidosis. She received continuous hemofiltration and hemodialysis, but the laboratory analyses showed no improvement. She died 11 hours after admission. Metformin is minimally bound to proteins and is readily dialyzable, but a prolonged period of dialysis is required, because metformin has a very large distribution volume and is distributed to multiple compartments. The peak blood metformin level was 432 mg/L in this case, which is one of the highest metformin concentrations ever reported, and eight hours of hemodialysis were not sufficient to reduce the serum level.

Original language	English
Pages (from-to)	775-778
Number of pages	4
Journal	Internal Medicine
Volume	55
Issue number	7
DOIs	https://doi.org/10.2169/internalmedicine.55.5415
Publication status	Published - 01-04-2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.55.5415

Cite this

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abstract = "A 72-year-old woman with a history of type 2 diabetes mellitus was brought to the ER with metforminassociated lactic acidosis. She received continuous hemofiltration and hemodialysis, but the laboratory analyses showed no improvement. She died 11 hours after admission. Metformin is minimally bound to proteins and is readily dialyzable, but a prolonged period of dialysis is required, because metformin has a very large distribution volume and is distributed to multiple compartments. The peak blood metformin level was 432 mg/L in this case, which is one of the highest metformin concentrations ever reported, and eight hours of hemodialysis were not sufficient to reduce the serum level.",

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AU - Ozeki, Toshikazu

AU - Kawato, Rui

AU - Watanabe, Mitsuru

AU - Minatoguchi, Shun

AU - Murai, Yukari

AU - Ryuge, Akihiro

AU - Takasugi, Koji

AU - Hamada, Takuya

AU - Oyama, Yukako

AU - Nomura, Atsushi

AU - Tomino, Tatsuhito

AU - Shimizu, Hideaki

AU - Fujita, Yoshiro

PY - 2016/4/1

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AB - A 72-year-old woman with a history of type 2 diabetes mellitus was brought to the ER with metforminassociated lactic acidosis. She received continuous hemofiltration and hemodialysis, but the laboratory analyses showed no improvement. She died 11 hours after admission. Metformin is minimally bound to proteins and is readily dialyzable, but a prolonged period of dialysis is required, because metformin has a very large distribution volume and is distributed to multiple compartments. The peak blood metformin level was 432 mg/L in this case, which is one of the highest metformin concentrations ever reported, and eight hours of hemodialysis were not sufficient to reduce the serum level.

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A fatal case of metformin-associated lactic acidosis

Abstract

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