TY - JOUR
T1 - A fatal case of overwhelming postsplenectomy infection syndrome developing 10 years after splenectomy
AU - Urata, Yukitomo
AU - Hasegawa, Midori
AU - Hasegawa, Hiroshi
AU - Shikano, Masahiko
AU - Kawashima, Shiro
AU - Imoto, Masami
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - Splenectomized patients are likely to suffer from severe infections, such as sepsis and meningitis. This syndrome is called overwhelming postsplenectomy infection (OPSI) in Europe and America. The course is rapid, the clinical symptoms are serious, and the prognosis is very poor. We treated one adult patient with OPSI syndrome that developed 10 years after splenectomy. Case: A 26-year-old man had undergone a splenectomy following a traffic accident 10 years previously. On January 7, 1996, he had diarrhea and nausea. On January 10, he became drowsy and presented at our hospital with multiple organ failure. He underwent hemodialysis and plasmapheresis because of acute renal failure and also received immue globulin, antibiotics and prednisolone. However, these medications were not effective. He died 7 hours later. We identified diplococcus on a blood smear, IgG 3 deficiency and a low titer of specific pneumococcal IgG 2 antibody. The autopsy findings in cluded bilateral acute hemorrhagic necrosis of the adrenal glands (Waterhouse-Friderichsen syndrome).
AB - Splenectomized patients are likely to suffer from severe infections, such as sepsis and meningitis. This syndrome is called overwhelming postsplenectomy infection (OPSI) in Europe and America. The course is rapid, the clinical symptoms are serious, and the prognosis is very poor. We treated one adult patient with OPSI syndrome that developed 10 years after splenectomy. Case: A 26-year-old man had undergone a splenectomy following a traffic accident 10 years previously. On January 7, 1996, he had diarrhea and nausea. On January 10, he became drowsy and presented at our hospital with multiple organ failure. He underwent hemodialysis and plasmapheresis because of acute renal failure and also received immue globulin, antibiotics and prednisolone. However, these medications were not effective. He died 7 hours later. We identified diplococcus on a blood smear, IgG 3 deficiency and a low titer of specific pneumococcal IgG 2 antibody. The autopsy findings in cluded bilateral acute hemorrhagic necrosis of the adrenal glands (Waterhouse-Friderichsen syndrome).
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U2 - 10.2177/jsci.20.184
DO - 10.2177/jsci.20.184
M3 - Article
C2 - 9256611
AN - SCOPUS:0031154308
VL - 20
SP - 184
EP - 190
JO - Immunological Medicine
JF - Immunological Medicine
SN - 0911-4300
IS - 3
ER -