A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Tomoko Tsunoka, Takenori Okumura, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: A recent study reported an association between rs2234693, which influences enhancer activity levels in estrogen receptor alpha gene (ESR1), and schizophrenia. This study reported that schizophrenic patients with the CC genotype have significantly lower ESR1 mRNA levels in the prefrontal cortex than patients with other genotypes. The symptoms of methamphetamine induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an association analysis of rs2234693 with Japanese methamphetamine induced psychosis patients. Method: Using rs2234693, we conducted a genetic association analysis of case-control samples (197 methamphetamine induced psychosis patients and 197 healthy controls). The age and sex of the control subjects did not differ from those of the methamphetamine induced psychosis patients. Results: We detected a significant association between ESR1 and methamphetamine induced psychosis patients in allele/genotype-wise analysis. For further interpretation of these associations, we performed single marker analysis of subjects divided by sex. Rs2234693 was associated with male methamphetamine induced psychosis. Discussion: Our results suggest that rs2234693 in ESR1 may play a role in the pathophysiology of Japanese methamphetamine induced psychosis patients. Crown

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number5
DOIs
Publication statusPublished - 01-08-2009

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis'. Together they form a unique fingerprint.

  • Cite this

    Kishi, T., Ikeda, M., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Okochi, T., Tsunoka, T., Okumura, T., Inada, T., Ujike, H., Yamada, M., Uchimura, N., Sora, I., Iyo, M., Ozaki, N., & Iwata, N. (2009). A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(5), 895-898. https://doi.org/10.1016/j.pnpbp.2009.04.008