A gas governing mucosal immunity

Hiroyuki Tezuka, Toshiaki Ohteki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Immunoglobulin A (IgA), the most abundant Ig isotype in the body under steady-state conditions, helps to protect the body from mucosally transmitted pathogens and to maintain the homeostasis of commensal bacteria at the mucosal surface. Although it is well known that IgA is predominantly produced in mucosa-associated lymphoid tissues (MALT), little is known about why IgA class switch recombination (CSR) occurs in these tissues. We recently showed that nitric oxide (NO) released by specialized dendritic cells (DCs) is essential for IgA CSR in the MALT.

Original languageEnglish
Pages (from-to)8039-8040
Number of pages2
JournalVaccine
Volume28
Issue number50
DOIs
Publication statusPublished - 23-11-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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