TY - JOUR
T1 - A gene outside the human MHC related to classical HLA class I genes
AU - Hashimoto, Keiichiro
AU - Hirai, Momoki
AU - Kurosawa, Yoshikazu
PY - 1995
Y1 - 1995
N2 - By presenting antigenic peptides to T lymphocytes, major histocompatibility complex (MHC) class molecules play important roles in the human immune system. Knowledge is limited on the evolutionary history of human MHC class I-related molecules. An expressed class gene, MR1, has now been identified on human chromosome 1q25, outside the MHC. In contrast to other known human divergent class genes, MR1 encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA) class genes on chromosome 6 and by nonmammalian classical MHC class genes. This gene may thus contribute to understanding the evolution of the MHC.
AB - By presenting antigenic peptides to T lymphocytes, major histocompatibility complex (MHC) class molecules play important roles in the human immune system. Knowledge is limited on the evolutionary history of human MHC class I-related molecules. An expressed class gene, MR1, has now been identified on human chromosome 1q25, outside the MHC. In contrast to other known human divergent class genes, MR1 encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA) class genes on chromosome 6 and by nonmammalian classical MHC class genes. This gene may thus contribute to understanding the evolution of the MHC.
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U2 - 10.1126/science.7624800
DO - 10.1126/science.7624800
M3 - Article
C2 - 7624800
AN - SCOPUS:0029038074
SN - 0036-8075
VL - 269
SP - 693
EP - 695
JO - Science
JF - Science
IS - 5224
ER -