A gene outside the human MHC related to classical HLA class I genes

Keiichiro Hashimoto, Momoki Hirai, Yoshikazu Kurosawa

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

By presenting antigenic peptides to T lymphocytes, major histocompatibility complex (MHC) class molecules play important roles in the human immune system. Knowledge is limited on the evolutionary history of human MHC class I-related molecules. An expressed class gene, MR1, has now been identified on human chromosome 1q25, outside the MHC. In contrast to other known human divergent class genes, MR1 encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA) class genes on chromosome 6 and by nonmammalian classical MHC class genes. This gene may thus contribute to understanding the evolution of the MHC.

Original languageEnglish
Pages (from-to)693-695
Number of pages3
JournalScience
Volume269
Issue number5224
DOIs
Publication statusPublished - 01-01-1995

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All Science Journal Classification (ASJC) codes

  • General

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