A gene outside the human MHC related to classical HLA class I genes

Keiichiro Hashimoto, Momoki Hirai, Yoshikazu Kurosawa

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

By presenting antigenic peptides to T lymphocytes, major histocompatibility complex (MHC) class molecules play important roles in the human immune system. Knowledge is limited on the evolutionary history of human MHC class I-related molecules. An expressed class gene, MR1, has now been identified on human chromosome 1q25, outside the MHC. In contrast to other known human divergent class genes, MR1 encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA) class genes on chromosome 6 and by nonmammalian classical MHC class genes. This gene may thus contribute to understanding the evolution of the MHC.

Original languageEnglish
Pages (from-to)693-695
Number of pages3
JournalScience
Volume269
Issue number5224
DOIs
Publication statusPublished - 01-01-1995

Fingerprint

MHC Class I Genes
HLA Antigens
Major Histocompatibility Complex
Genes
Peptide T
Chromosomes, Human, Pair 6
Human Chromosomes
Immune System
History
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Hashimoto, Keiichiro ; Hirai, Momoki ; Kurosawa, Yoshikazu. / A gene outside the human MHC related to classical HLA class I genes. In: Science. 1995 ; Vol. 269, No. 5224. pp. 693-695.
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A gene outside the human MHC related to classical HLA class I genes. / Hashimoto, Keiichiro; Hirai, Momoki; Kurosawa, Yoshikazu.

In: Science, Vol. 269, No. 5224, 01.01.1995, p. 693-695.

Research output: Contribution to journalArticle

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