[A genetic background of ulcer diseases induced by NSAID/aspirin].

Tomiyasu Arisawa, Tomomitsu Tahara, Masakatsu Nakamura

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The association between peptic ulcer diseases and polymorphisms in various genes, including HRH2, COX-1, IL-17A. IL-17F, MIF and Nrf2 genes, are seen. COX-1 has traditionally been regarded as a constitutively expressed enzyme that generates prostaglandins for gastrointestinal integrity. The effects of NSAID/aspirin on the gastric mucosal damage are caused by the inhibition of this enzyme. A T-1676C polymorphism (rs1330344) was significantly associated with the development of peptic ulcer, especially gastric ulcer. In addition, rs1330344 was also significantly associated with the development of NSAID/aspirin-induced ulcer diseases. In conclusions, the assessment for genotype of COX-1 gene promoter polymorphism, especially rs1330344, may be useful for detecting the high risk group of developing NSAID/aspirin-induced ulcer diseases.

Original languageEnglish
Pages (from-to)2113-2118
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume68
Issue number11
Publication statusPublished - 01-11-2010
Externally publishedYes

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Non-Steroidal Anti-Inflammatory Agents
Aspirin
Ulcer
Interleukin-17
Peptic Ulcer
Genes
Enzymes
Stomach Ulcer
Prostaglandins
Stomach
Genotype
Genetic Background

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "The association between peptic ulcer diseases and polymorphisms in various genes, including HRH2, COX-1, IL-17A. IL-17F, MIF and Nrf2 genes, are seen. COX-1 has traditionally been regarded as a constitutively expressed enzyme that generates prostaglandins for gastrointestinal integrity. The effects of NSAID/aspirin on the gastric mucosal damage are caused by the inhibition of this enzyme. A T-1676C polymorphism (rs1330344) was significantly associated with the development of peptic ulcer, especially gastric ulcer. In addition, rs1330344 was also significantly associated with the development of NSAID/aspirin-induced ulcer diseases. In conclusions, the assessment for genotype of COX-1 gene promoter polymorphism, especially rs1330344, may be useful for detecting the high risk group of developing NSAID/aspirin-induced ulcer diseases.",
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[A genetic background of ulcer diseases induced by NSAID/aspirin]. / Arisawa, Tomiyasu; Tahara, Tomomitsu; Nakamura, Masakatsu.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 68, No. 11, 01.11.2010, p. 2113-2118.

Research output: Contribution to journalReview article

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AU - Tahara, Tomomitsu

AU - Nakamura, Masakatsu

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