[A genetic background of ulcer diseases induced by NSAID/aspirin].

Tomiyasu Arisawa, Tomomitsu Tahara, Masakatsu Nakamura

Research output: Contribution to journalReview article

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Abstract

The association between peptic ulcer diseases and polymorphisms in various genes, including HRH2, COX-1, IL-17A. IL-17F, MIF and Nrf2 genes, are seen. COX-1 has traditionally been regarded as a constitutively expressed enzyme that generates prostaglandins for gastrointestinal integrity. The effects of NSAID/aspirin on the gastric mucosal damage are caused by the inhibition of this enzyme. A T-1676C polymorphism (rs1330344) was significantly associated with the development of peptic ulcer, especially gastric ulcer. In addition, rs1330344 was also significantly associated with the development of NSAID/aspirin-induced ulcer diseases. In conclusions, the assessment for genotype of COX-1 gene promoter polymorphism, especially rs1330344, may be useful for detecting the high risk group of developing NSAID/aspirin-induced ulcer diseases.

Original languageEnglish
Pages (from-to)2113-2118
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume68
Issue number11
Publication statusPublished - 11-2010

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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