A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals

Tomomitsu Tahara, Tomoyuki Shibata, Fangyu Wang, Masakatsu Nakamura, Mikijyu Sakata, Hiroshi Nakano, Ichiro Hirata, Tomiyasu Arisawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

OBJECTVE: Although inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD), detailed data regarding the relationship between the genetic regulatory factors of inflammation and FD are not available. Superoxide has been implicated in the pathogenesis of Helicobacter pylrori-related diseases through inflammation. Nicotinamide adenine dinucleotide phosphate oxidase, a major source of superoxide generation plays a critical role in H. pylori-related gastric inflammation. We aimed to clarify the association between C242T polymorphism of p22PHOX, an essential component of nicotinamide adenine dinucleotide phosphate oxidase and FD in a Japanese population. METHODS: Eighty-nine FD according to Rome III criteria and 95 asymptomatic participants enrolled in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism. H. pylori infection status was examined by histology or antibody against H. pylori. RESULTS: Nonsignificant correlation was found between p22PHOX polymorphism and FD. In H. pylori positives, however, C242T carriers significantly associated lower risk of FD (25.9 vs. 6.2%; C/C vs. T carriers; odds ratio=0.19, 95% confidence interval=0.05-0.71, P=0.009). This significant association remained after logistic regression analysis with adjustment for sex and age (odds ratio=0.20, 95% confidence interval=0.05-0.73). No significant correlation was found between p22PHOX polymorphism and a different subgroup of FD. CONCLUSION: Our data suggest that C242T carriers status is inversely related to the risk of FD in H. pylori-infected patients.

Original languageEnglish
Pages (from-to)1363-1368
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume21
Issue number12
DOIs
Publication statusPublished - 01-12-2009

Fingerprint

NADPH Oxidase
Dyspepsia
Helicobacter pylori
Inflammation
NADP
Superoxides
Oxidoreductases
Odds Ratio
Confidence Intervals
Helicobacter
Helicobacter Infections
Gastric Mucosa
Restriction Fragment Length Polymorphisms
Stomach
Histology
Logistic Models
Regression Analysis
Polymerase Chain Reaction
Antibodies
Population

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Tahara, Tomomitsu ; Shibata, Tomoyuki ; Wang, Fangyu ; Nakamura, Masakatsu ; Sakata, Mikijyu ; Nakano, Hiroshi ; Hirata, Ichiro ; Arisawa, Tomiyasu. / A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals. In: European Journal of Gastroenterology and Hepatology. 2009 ; Vol. 21, No. 12. pp. 1363-1368.
@article{c39be8d0e56841fd82cedcf0a82bd670,
title = "A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals",
abstract = "OBJECTVE: Although inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD), detailed data regarding the relationship between the genetic regulatory factors of inflammation and FD are not available. Superoxide has been implicated in the pathogenesis of Helicobacter pylrori-related diseases through inflammation. Nicotinamide adenine dinucleotide phosphate oxidase, a major source of superoxide generation plays a critical role in H. pylori-related gastric inflammation. We aimed to clarify the association between C242T polymorphism of p22PHOX, an essential component of nicotinamide adenine dinucleotide phosphate oxidase and FD in a Japanese population. METHODS: Eighty-nine FD according to Rome III criteria and 95 asymptomatic participants enrolled in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism. H. pylori infection status was examined by histology or antibody against H. pylori. RESULTS: Nonsignificant correlation was found between p22PHOX polymorphism and FD. In H. pylori positives, however, C242T carriers significantly associated lower risk of FD (25.9 vs. 6.2{\%}; C/C vs. T carriers; odds ratio=0.19, 95{\%} confidence interval=0.05-0.71, P=0.009). This significant association remained after logistic regression analysis with adjustment for sex and age (odds ratio=0.20, 95{\%} confidence interval=0.05-0.73). No significant correlation was found between p22PHOX polymorphism and a different subgroup of FD. CONCLUSION: Our data suggest that C242T carriers status is inversely related to the risk of FD in H. pylori-infected patients.",
author = "Tomomitsu Tahara and Tomoyuki Shibata and Fangyu Wang and Masakatsu Nakamura and Mikijyu Sakata and Hiroshi Nakano and Ichiro Hirata and Tomiyasu Arisawa",
year = "2009",
month = "12",
day = "1",
doi = "10.1097/MEG.0b013e32830e2871",
language = "English",
volume = "21",
pages = "1363--1368",
journal = "European Journal of Gastroenterology and Hepatology",
issn = "0954-691X",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals. / Tahara, Tomomitsu; Shibata, Tomoyuki; Wang, Fangyu; Nakamura, Masakatsu; Sakata, Mikijyu; Nakano, Hiroshi; Hirata, Ichiro; Arisawa, Tomiyasu.

In: European Journal of Gastroenterology and Hepatology, Vol. 21, No. 12, 01.12.2009, p. 1363-1368.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Wang, Fangyu

AU - Nakamura, Masakatsu

AU - Sakata, Mikijyu

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

AU - Arisawa, Tomiyasu

PY - 2009/12/1

Y1 - 2009/12/1

N2 - OBJECTVE: Although inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD), detailed data regarding the relationship between the genetic regulatory factors of inflammation and FD are not available. Superoxide has been implicated in the pathogenesis of Helicobacter pylrori-related diseases through inflammation. Nicotinamide adenine dinucleotide phosphate oxidase, a major source of superoxide generation plays a critical role in H. pylori-related gastric inflammation. We aimed to clarify the association between C242T polymorphism of p22PHOX, an essential component of nicotinamide adenine dinucleotide phosphate oxidase and FD in a Japanese population. METHODS: Eighty-nine FD according to Rome III criteria and 95 asymptomatic participants enrolled in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism. H. pylori infection status was examined by histology or antibody against H. pylori. RESULTS: Nonsignificant correlation was found between p22PHOX polymorphism and FD. In H. pylori positives, however, C242T carriers significantly associated lower risk of FD (25.9 vs. 6.2%; C/C vs. T carriers; odds ratio=0.19, 95% confidence interval=0.05-0.71, P=0.009). This significant association remained after logistic regression analysis with adjustment for sex and age (odds ratio=0.20, 95% confidence interval=0.05-0.73). No significant correlation was found between p22PHOX polymorphism and a different subgroup of FD. CONCLUSION: Our data suggest that C242T carriers status is inversely related to the risk of FD in H. pylori-infected patients.

AB - OBJECTVE: Although inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD), detailed data regarding the relationship between the genetic regulatory factors of inflammation and FD are not available. Superoxide has been implicated in the pathogenesis of Helicobacter pylrori-related diseases through inflammation. Nicotinamide adenine dinucleotide phosphate oxidase, a major source of superoxide generation plays a critical role in H. pylori-related gastric inflammation. We aimed to clarify the association between C242T polymorphism of p22PHOX, an essential component of nicotinamide adenine dinucleotide phosphate oxidase and FD in a Japanese population. METHODS: Eighty-nine FD according to Rome III criteria and 95 asymptomatic participants enrolled in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism. H. pylori infection status was examined by histology or antibody against H. pylori. RESULTS: Nonsignificant correlation was found between p22PHOX polymorphism and FD. In H. pylori positives, however, C242T carriers significantly associated lower risk of FD (25.9 vs. 6.2%; C/C vs. T carriers; odds ratio=0.19, 95% confidence interval=0.05-0.71, P=0.009). This significant association remained after logistic regression analysis with adjustment for sex and age (odds ratio=0.20, 95% confidence interval=0.05-0.73). No significant correlation was found between p22PHOX polymorphism and a different subgroup of FD. CONCLUSION: Our data suggest that C242T carriers status is inversely related to the risk of FD in H. pylori-infected patients.

UR - http://www.scopus.com/inward/record.url?scp=77950238278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950238278&partnerID=8YFLogxK

U2 - 10.1097/MEG.0b013e32830e2871

DO - 10.1097/MEG.0b013e32830e2871

M3 - Article

C2 - 19531958

AN - SCOPUS:77950238278

VL - 21

SP - 1363

EP - 1368

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

SN - 0954-691X

IS - 12

ER -