A genome-wide association study identifies 2 susceptibility loci for crohn's disease in a Japanese population

Keiko Yamazaki, Junji Umeno, Atsushi Takahashi, Atsushi Hirano, Todd Andrew Johnson, Natsuhiko Kumasaka, Takashi Morizono, Naoya Hosono, Takaaki Kawaguchi, Masakazu Takazoe, Tetsuhiro Yamada, Yasuo Suzuki, Hiroki Tanaka, Satoshi Motoya, Masayo Hosokawa, Yoshiaki Arimura, Yasuhisa Shinomura, Toshiyuki Matsui, Takayuki Matsumoto, Mitsuo IidaTatsuhiko Tsunoda, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo

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Abstract

Background & Aims: Crohn's disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect the risk for Crohn's disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn's disease in the Japanese population. Methods: We performed a genome-wide association study with 372 individuals with Crohn's disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn's disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort. Results: We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10 -59), TNFSF15 (rs6478106, P = 3.87 × 10-45), and STAT3 (rs9891119, P = 2.24 × 10-14). We identified 2 new susceptibility loci: on chromosome 4p14 (rs1487630, P = 2.40 × 10 -11; odds ratio, 1.33), and in the SLC25A15-ELF1-WBP4 region on 13q14 (rs7329174 in ELF1, P = 5.12 × 10-9; odds ratio, 1.27). Conclusions: In a genome-wide association study, we identified 2 new susceptibility loci for Crohn's disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn's disease.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalGastroenterology
Volume144
Issue number4
DOIs
Publication statusPublished - 04-2013

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Genome-Wide Association Study
Crohn Disease
Population
Odds Ratio
Inflammatory Bowel Diseases
Ethnic Groups
Chromosomes
Genotype

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Yamazaki, Keiko ; Umeno, Junji ; Takahashi, Atsushi ; Hirano, Atsushi ; Johnson, Todd Andrew ; Kumasaka, Natsuhiko ; Morizono, Takashi ; Hosono, Naoya ; Kawaguchi, Takaaki ; Takazoe, Masakazu ; Yamada, Tetsuhiro ; Suzuki, Yasuo ; Tanaka, Hiroki ; Motoya, Satoshi ; Hosokawa, Masayo ; Arimura, Yoshiaki ; Shinomura, Yasuhisa ; Matsui, Toshiyuki ; Matsumoto, Takayuki ; Iida, Mitsuo ; Tsunoda, Tatsuhiko ; Nakamura, Yusuke ; Kamatani, Naoyuki ; Kubo, Michiaki. / A genome-wide association study identifies 2 susceptibility loci for crohn's disease in a Japanese population. In: Gastroenterology. 2013 ; Vol. 144, No. 4. pp. 781-788.
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title = "A genome-wide association study identifies 2 susceptibility loci for crohn's disease in a Japanese population",
abstract = "Background & Aims: Crohn's disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect the risk for Crohn's disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn's disease in the Japanese population. Methods: We performed a genome-wide association study with 372 individuals with Crohn's disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn's disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort. Results: We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10 -59), TNFSF15 (rs6478106, P = 3.87 × 10-45), and STAT3 (rs9891119, P = 2.24 × 10-14). We identified 2 new susceptibility loci: on chromosome 4p14 (rs1487630, P = 2.40 × 10 -11; odds ratio, 1.33), and in the SLC25A15-ELF1-WBP4 region on 13q14 (rs7329174 in ELF1, P = 5.12 × 10-9; odds ratio, 1.27). Conclusions: In a genome-wide association study, we identified 2 new susceptibility loci for Crohn's disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn's disease.",
author = "Keiko Yamazaki and Junji Umeno and Atsushi Takahashi and Atsushi Hirano and Johnson, {Todd Andrew} and Natsuhiko Kumasaka and Takashi Morizono and Naoya Hosono and Takaaki Kawaguchi and Masakazu Takazoe and Tetsuhiro Yamada and Yasuo Suzuki and Hiroki Tanaka and Satoshi Motoya and Masayo Hosokawa and Yoshiaki Arimura and Yasuhisa Shinomura and Toshiyuki Matsui and Takayuki Matsumoto and Mitsuo Iida and Tatsuhiko Tsunoda and Yusuke Nakamura and Naoyuki Kamatani and Michiaki Kubo",
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Yamazaki, K, Umeno, J, Takahashi, A, Hirano, A, Johnson, TA, Kumasaka, N, Morizono, T, Hosono, N, Kawaguchi, T, Takazoe, M, Yamada, T, Suzuki, Y, Tanaka, H, Motoya, S, Hosokawa, M, Arimura, Y, Shinomura, Y, Matsui, T, Matsumoto, T, Iida, M, Tsunoda, T, Nakamura, Y, Kamatani, N & Kubo, M 2013, 'A genome-wide association study identifies 2 susceptibility loci for crohn's disease in a Japanese population', Gastroenterology, vol. 144, no. 4, pp. 781-788. https://doi.org/10.1053/j.gastro.2012.12.021

A genome-wide association study identifies 2 susceptibility loci for crohn's disease in a Japanese population. / Yamazaki, Keiko; Umeno, Junji; Takahashi, Atsushi; Hirano, Atsushi; Johnson, Todd Andrew; Kumasaka, Natsuhiko; Morizono, Takashi; Hosono, Naoya; Kawaguchi, Takaaki; Takazoe, Masakazu; Yamada, Tetsuhiro; Suzuki, Yasuo; Tanaka, Hiroki; Motoya, Satoshi; Hosokawa, Masayo; Arimura, Yoshiaki; Shinomura, Yasuhisa; Matsui, Toshiyuki; Matsumoto, Takayuki; Iida, Mitsuo; Tsunoda, Tatsuhiko; Nakamura, Yusuke; Kamatani, Naoyuki; Kubo, Michiaki.

In: Gastroenterology, Vol. 144, No. 4, 04.2013, p. 781-788.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A genome-wide association study identifies 2 susceptibility loci for crohn's disease in a Japanese population

AU - Yamazaki, Keiko

AU - Umeno, Junji

AU - Takahashi, Atsushi

AU - Hirano, Atsushi

AU - Johnson, Todd Andrew

AU - Kumasaka, Natsuhiko

AU - Morizono, Takashi

AU - Hosono, Naoya

AU - Kawaguchi, Takaaki

AU - Takazoe, Masakazu

AU - Yamada, Tetsuhiro

AU - Suzuki, Yasuo

AU - Tanaka, Hiroki

AU - Motoya, Satoshi

AU - Hosokawa, Masayo

AU - Arimura, Yoshiaki

AU - Shinomura, Yasuhisa

AU - Matsui, Toshiyuki

AU - Matsumoto, Takayuki

AU - Iida, Mitsuo

AU - Tsunoda, Tatsuhiko

AU - Nakamura, Yusuke

AU - Kamatani, Naoyuki

AU - Kubo, Michiaki

PY - 2013/4

Y1 - 2013/4

N2 - Background & Aims: Crohn's disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect the risk for Crohn's disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn's disease in the Japanese population. Methods: We performed a genome-wide association study with 372 individuals with Crohn's disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn's disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort. Results: We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10 -59), TNFSF15 (rs6478106, P = 3.87 × 10-45), and STAT3 (rs9891119, P = 2.24 × 10-14). We identified 2 new susceptibility loci: on chromosome 4p14 (rs1487630, P = 2.40 × 10 -11; odds ratio, 1.33), and in the SLC25A15-ELF1-WBP4 region on 13q14 (rs7329174 in ELF1, P = 5.12 × 10-9; odds ratio, 1.27). Conclusions: In a genome-wide association study, we identified 2 new susceptibility loci for Crohn's disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn's disease.

AB - Background & Aims: Crohn's disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect the risk for Crohn's disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn's disease in the Japanese population. Methods: We performed a genome-wide association study with 372 individuals with Crohn's disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn's disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort. Results: We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10 -59), TNFSF15 (rs6478106, P = 3.87 × 10-45), and STAT3 (rs9891119, P = 2.24 × 10-14). We identified 2 new susceptibility loci: on chromosome 4p14 (rs1487630, P = 2.40 × 10 -11; odds ratio, 1.33), and in the SLC25A15-ELF1-WBP4 region on 13q14 (rs7329174 in ELF1, P = 5.12 × 10-9; odds ratio, 1.27). Conclusions: In a genome-wide association study, we identified 2 new susceptibility loci for Crohn's disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn's disease.

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