A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese

Seham Elgazzar, Hitoshi Zembutsu, Atsushi Takahashi, Michiaki Kubo, Fuminori Aki, Koichi Hirata, Yuichi Takatsuka, Minoru Okazaki, Shozo Ohsumi, Takashi Yamakawa, Mitsunori Sasa, Toyomasa Katagiri, Yoshio Miki, Yusuke Nakamura

Research output: Contribution to journalArticle

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Abstract

In Japan, breast cancer is the most common cancer among women and the second leading cause of cancer death among women worldwide. To identify genetic variants associated with the disease susceptibility, we performed a genome-wide association study (GWAS) using a total of 1086 Japanese female patients with hormonal receptor-positive (HRP) breast cancer and 1816 female controls. We selected 33 single-nucleotide polymorphisms (SNPs) with suggestive associations in GWAS (P-value of <1 × 10-4) as well as 4 SNPs that were previously implicated their association with breast cancer for further replication by an independent set of 1653 cases and 2797 controls. We identified significant association of the disease with a SNP rs6788895 (P combined of 9.43 × 10-8 with odds ratio (OR) of 1.22) in the SIAH2 (intron of seven in absentia homolog 2) gene on chromosome 3q25.1 where the involvement in estrogen-dependent diseases was suggested. In addition, rs3750817 in intron 2 of the fibroblast growth factor receptor 2 gene, which was reported to be associated with breast cancer susceptibility, was significantly replicated with P combined of 8.47 × 10-8 with OR=1.22. Our results suggest a novel susceptibility locus on chromosome 3q25.1 for a HRP breast cancer.

Original languageEnglish
Pages (from-to)766-771
Number of pages6
JournalJournal of Human Genetics
Volume57
Issue number12
DOIs
Publication statusPublished - 01-12-2012

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Genome-Wide Association Study
Introns
Breast Neoplasms
Single Nucleotide Polymorphism
Chromosomes
Receptor, Fibroblast Growth Factor, Type 2
Odds Ratio
Disease Susceptibility
Genes
Cause of Death
Neoplasms
Japan
Estrogens

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Elgazzar, Seham ; Zembutsu, Hitoshi ; Takahashi, Atsushi ; Kubo, Michiaki ; Aki, Fuminori ; Hirata, Koichi ; Takatsuka, Yuichi ; Okazaki, Minoru ; Ohsumi, Shozo ; Yamakawa, Takashi ; Sasa, Mitsunori ; Katagiri, Toyomasa ; Miki, Yoshio ; Nakamura, Yusuke. / A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese. In: Journal of Human Genetics. 2012 ; Vol. 57, No. 12. pp. 766-771.
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abstract = "In Japan, breast cancer is the most common cancer among women and the second leading cause of cancer death among women worldwide. To identify genetic variants associated with the disease susceptibility, we performed a genome-wide association study (GWAS) using a total of 1086 Japanese female patients with hormonal receptor-positive (HRP) breast cancer and 1816 female controls. We selected 33 single-nucleotide polymorphisms (SNPs) with suggestive associations in GWAS (P-value of <1 × 10-4) as well as 4 SNPs that were previously implicated their association with breast cancer for further replication by an independent set of 1653 cases and 2797 controls. We identified significant association of the disease with a SNP rs6788895 (P combined of 9.43 × 10-8 with odds ratio (OR) of 1.22) in the SIAH2 (intron of seven in absentia homolog 2) gene on chromosome 3q25.1 where the involvement in estrogen-dependent diseases was suggested. In addition, rs3750817 in intron 2 of the fibroblast growth factor receptor 2 gene, which was reported to be associated with breast cancer susceptibility, was significantly replicated with P combined of 8.47 × 10-8 with OR=1.22. Our results suggest a novel susceptibility locus on chromosome 3q25.1 for a HRP breast cancer.",
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Elgazzar, S, Zembutsu, H, Takahashi, A, Kubo, M, Aki, F, Hirata, K, Takatsuka, Y, Okazaki, M, Ohsumi, S, Yamakawa, T, Sasa, M, Katagiri, T, Miki, Y & Nakamura, Y 2012, 'A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese', Journal of Human Genetics, vol. 57, no. 12, pp. 766-771. https://doi.org/10.1038/jhg.2012.108

A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese. / Elgazzar, Seham; Zembutsu, Hitoshi; Takahashi, Atsushi; Kubo, Michiaki; Aki, Fuminori; Hirata, Koichi; Takatsuka, Yuichi; Okazaki, Minoru; Ohsumi, Shozo; Yamakawa, Takashi; Sasa, Mitsunori; Katagiri, Toyomasa; Miki, Yoshio; Nakamura, Yusuke.

In: Journal of Human Genetics, Vol. 57, No. 12, 01.12.2012, p. 766-771.

Research output: Contribution to journalArticle

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T1 - A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese

AU - Elgazzar, Seham

AU - Zembutsu, Hitoshi

AU - Takahashi, Atsushi

AU - Kubo, Michiaki

AU - Aki, Fuminori

AU - Hirata, Koichi

AU - Takatsuka, Yuichi

AU - Okazaki, Minoru

AU - Ohsumi, Shozo

AU - Yamakawa, Takashi

AU - Sasa, Mitsunori

AU - Katagiri, Toyomasa

AU - Miki, Yoshio

AU - Nakamura, Yusuke

PY - 2012/12/1

Y1 - 2012/12/1

N2 - In Japan, breast cancer is the most common cancer among women and the second leading cause of cancer death among women worldwide. To identify genetic variants associated with the disease susceptibility, we performed a genome-wide association study (GWAS) using a total of 1086 Japanese female patients with hormonal receptor-positive (HRP) breast cancer and 1816 female controls. We selected 33 single-nucleotide polymorphisms (SNPs) with suggestive associations in GWAS (P-value of <1 × 10-4) as well as 4 SNPs that were previously implicated their association with breast cancer for further replication by an independent set of 1653 cases and 2797 controls. We identified significant association of the disease with a SNP rs6788895 (P combined of 9.43 × 10-8 with odds ratio (OR) of 1.22) in the SIAH2 (intron of seven in absentia homolog 2) gene on chromosome 3q25.1 where the involvement in estrogen-dependent diseases was suggested. In addition, rs3750817 in intron 2 of the fibroblast growth factor receptor 2 gene, which was reported to be associated with breast cancer susceptibility, was significantly replicated with P combined of 8.47 × 10-8 with OR=1.22. Our results suggest a novel susceptibility locus on chromosome 3q25.1 for a HRP breast cancer.

AB - In Japan, breast cancer is the most common cancer among women and the second leading cause of cancer death among women worldwide. To identify genetic variants associated with the disease susceptibility, we performed a genome-wide association study (GWAS) using a total of 1086 Japanese female patients with hormonal receptor-positive (HRP) breast cancer and 1816 female controls. We selected 33 single-nucleotide polymorphisms (SNPs) with suggestive associations in GWAS (P-value of <1 × 10-4) as well as 4 SNPs that were previously implicated their association with breast cancer for further replication by an independent set of 1653 cases and 2797 controls. We identified significant association of the disease with a SNP rs6788895 (P combined of 9.43 × 10-8 with odds ratio (OR) of 1.22) in the SIAH2 (intron of seven in absentia homolog 2) gene on chromosome 3q25.1 where the involvement in estrogen-dependent diseases was suggested. In addition, rs3750817 in intron 2 of the fibroblast growth factor receptor 2 gene, which was reported to be associated with breast cancer susceptibility, was significantly replicated with P combined of 8.47 × 10-8 with OR=1.22. Our results suggest a novel susceptibility locus on chromosome 3q25.1 for a HRP breast cancer.

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