A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis

Yohei Takahashi, Ikuyo Kou, Atsushi Takahashi, Todd A. Johnson, Katsuki Kono, Noriaki Kawakami, Koki Uno, Manabu Ito, Shohei Minami, Haruhisa Yanagida, Hiroshi Taneichi, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Toshiaki Kotani, Kota Watanabe, Kazuhiro Chiba, Naoya Hosono, Naoyuki Kamatani, Tatsuhiko Tsunoda & 4 others Yoshiaki Toyama, Michiaki Kubo, Morio Matsumoto, Shiro Ikegawa

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Adolescent idiopathic scoliosis is a pediatric spinal deformity affecting 2-3% of school-age children worldwide. Genetic factors have been implicated in its etiology. Through a genome-wide association study (GWAS) and replication study involving a total of 1,376 Japanese females with adolescent idiopathic scoliosis and 11,297 female controls, we identified a locus at chromosome 10q24.31 associated with adolescent idiopathic scoliosis susceptibility. The most significant SNP (rs11190870; combined P = 1.24 × 10 -19; odds ratio (OR) = 1.56) is located near LBX1 (encoding ladybird homeobox 1). The identification of this susceptibility locus provides new insights into the pathogenesis of adolescent idiopathic scoliosis.

Original languageEnglish
Pages (from-to)1237-1240
Number of pages4
JournalNature Genetics
Volume43
Issue number12
DOIs
Publication statusPublished - 01-12-2011

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Homeobox Genes
Genome-Wide Association Study
Scoliosis
Single Nucleotide Polymorphism
Chromosomes
Odds Ratio
Pediatrics

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Takahashi, Y., Kou, I., Takahashi, A., Johnson, T. A., Kono, K., Kawakami, N., ... Ikegawa, S. (2011). A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. Nature Genetics, 43(12), 1237-1240. https://doi.org/10.1038/ng.974
Takahashi, Yohei ; Kou, Ikuyo ; Takahashi, Atsushi ; Johnson, Todd A. ; Kono, Katsuki ; Kawakami, Noriaki ; Uno, Koki ; Ito, Manabu ; Minami, Shohei ; Yanagida, Haruhisa ; Taneichi, Hiroshi ; Tsuji, Taichi ; Suzuki, Teppei ; Sudo, Hideki ; Kotani, Toshiaki ; Watanabe, Kota ; Chiba, Kazuhiro ; Hosono, Naoya ; Kamatani, Naoyuki ; Tsunoda, Tatsuhiko ; Toyama, Yoshiaki ; Kubo, Michiaki ; Matsumoto, Morio ; Ikegawa, Shiro. / A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. In: Nature Genetics. 2011 ; Vol. 43, No. 12. pp. 1237-1240.
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abstract = "Adolescent idiopathic scoliosis is a pediatric spinal deformity affecting 2-3{\%} of school-age children worldwide. Genetic factors have been implicated in its etiology. Through a genome-wide association study (GWAS) and replication study involving a total of 1,376 Japanese females with adolescent idiopathic scoliosis and 11,297 female controls, we identified a locus at chromosome 10q24.31 associated with adolescent idiopathic scoliosis susceptibility. The most significant SNP (rs11190870; combined P = 1.24 × 10 -19; odds ratio (OR) = 1.56) is located near LBX1 (encoding ladybird homeobox 1). The identification of this susceptibility locus provides new insights into the pathogenesis of adolescent idiopathic scoliosis.",
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Takahashi, Y, Kou, I, Takahashi, A, Johnson, TA, Kono, K, Kawakami, N, Uno, K, Ito, M, Minami, S, Yanagida, H, Taneichi, H, Tsuji, T, Suzuki, T, Sudo, H, Kotani, T, Watanabe, K, Chiba, K, Hosono, N, Kamatani, N, Tsunoda, T, Toyama, Y, Kubo, M, Matsumoto, M & Ikegawa, S 2011, 'A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis', Nature Genetics, vol. 43, no. 12, pp. 1237-1240. https://doi.org/10.1038/ng.974

A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. / Takahashi, Yohei; Kou, Ikuyo; Takahashi, Atsushi; Johnson, Todd A.; Kono, Katsuki; Kawakami, Noriaki; Uno, Koki; Ito, Manabu; Minami, Shohei; Yanagida, Haruhisa; Taneichi, Hiroshi; Tsuji, Taichi; Suzuki, Teppei; Sudo, Hideki; Kotani, Toshiaki; Watanabe, Kota; Chiba, Kazuhiro; Hosono, Naoya; Kamatani, Naoyuki; Tsunoda, Tatsuhiko; Toyama, Yoshiaki; Kubo, Michiaki; Matsumoto, Morio; Ikegawa, Shiro.

In: Nature Genetics, Vol. 43, No. 12, 01.12.2011, p. 1237-1240.

Research output: Contribution to journalArticle

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T1 - A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis

AU - Takahashi, Yohei

AU - Kou, Ikuyo

AU - Takahashi, Atsushi

AU - Johnson, Todd A.

AU - Kono, Katsuki

AU - Kawakami, Noriaki

AU - Uno, Koki

AU - Ito, Manabu

AU - Minami, Shohei

AU - Yanagida, Haruhisa

AU - Taneichi, Hiroshi

AU - Tsuji, Taichi

AU - Suzuki, Teppei

AU - Sudo, Hideki

AU - Kotani, Toshiaki

AU - Watanabe, Kota

AU - Chiba, Kazuhiro

AU - Hosono, Naoya

AU - Kamatani, Naoyuki

AU - Tsunoda, Tatsuhiko

AU - Toyama, Yoshiaki

AU - Kubo, Michiaki

AU - Matsumoto, Morio

AU - Ikegawa, Shiro

PY - 2011/12/1

Y1 - 2011/12/1

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