A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids

Pei Chieng Cha; Atsushi Takahashi; Naoya Hosono; Siew Kee Low; Naoyuki Kamatani; Michiaki Kubo; Yusuke Nakamura

doi:10.1038/ng.805

A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids

Pei Chieng Cha, Atsushi Takahashi, Naoya Hosono, Siew Kee Low, Naoyuki Kamatani, Michiaki Kubo, Yusuke Nakamura

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

Uterine fibroids are a common benign tumor of the female genital tract. We conducted a genome-wide association study in which 457,044 SNPs were analyzed in 1,607 individuals with clinically diagnosed uterine fibroids and 1,428 female controls. SNPs showing suggestive associations (P < 5 × 10 ^-5) were further genotyped in 3,466 additional cases and 3,245 female controls. Three loci on chromosomes 10⁺24.33, 22⁺13.1 and 11⁺15.5 revealed genome-wide significant associations with uterine fibroids. The SNPs showing the most significant association in a combination analysis at each of these loci were rs7913069 (P = 8.65 × 10 ^-14, odds ratio (OR) = 1.47), rs12484776 (P = 2.79 × 10 ^-12, OR = 1.23) and rs2280543 (P = 3.82 × 10 ^-12, OR = 1.39), respectively. Subsequent fine mapping of these regions will be necessary to pinpoint the causal variants. Our findings should shed light on the pathogenesis of uterine fibroids.

Original language	English
Pages (from-to)	447-451
Number of pages	5
Journal	Nature Genetics
Volume	43
Issue number	5
DOIs	https://doi.org/10.1038/ng.805
Publication status	Published - 05-2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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title = "A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids",

abstract = "Uterine fibroids are a common benign tumor of the female genital tract. We conducted a genome-wide association study in which 457,044 SNPs were analyzed in 1,607 individuals with clinically diagnosed uterine fibroids and 1,428 female controls. SNPs showing suggestive associations (P < 5 × 10 -5) were further genotyped in 3,466 additional cases and 3,245 female controls. Three loci on chromosomes 10+24.33, 22+13.1 and 11+15.5 revealed genome-wide significant associations with uterine fibroids. The SNPs showing the most significant association in a combination analysis at each of these loci were rs7913069 (P = 8.65 × 10 -14, odds ratio (OR) = 1.47), rs12484776 (P = 2.79 × 10 -12, OR = 1.23) and rs2280543 (P = 3.82 × 10 -12, OR = 1.39), respectively. Subsequent fine mapping of these regions will be necessary to pinpoint the causal variants. Our findings should shed light on the pathogenesis of uterine fibroids.",

author = "Cha, {Pei Chieng} and Atsushi Takahashi and Naoya Hosono and Low, {Siew Kee} and Naoyuki Kamatani and Michiaki Kubo and Yusuke Nakamura",

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AU - Cha, Pei Chieng

AU - Takahashi, Atsushi

AU - Hosono, Naoya

AU - Low, Siew Kee

AU - Kamatani, Naoyuki

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

PY - 2011/5

Y1 - 2011/5

N2 - Uterine fibroids are a common benign tumor of the female genital tract. We conducted a genome-wide association study in which 457,044 SNPs were analyzed in 1,607 individuals with clinically diagnosed uterine fibroids and 1,428 female controls. SNPs showing suggestive associations (P < 5 × 10 -5) were further genotyped in 3,466 additional cases and 3,245 female controls. Three loci on chromosomes 10+24.33, 22+13.1 and 11+15.5 revealed genome-wide significant associations with uterine fibroids. The SNPs showing the most significant association in a combination analysis at each of these loci were rs7913069 (P = 8.65 × 10 -14, odds ratio (OR) = 1.47), rs12484776 (P = 2.79 × 10 -12, OR = 1.23) and rs2280543 (P = 3.82 × 10 -12, OR = 1.39), respectively. Subsequent fine mapping of these regions will be necessary to pinpoint the causal variants. Our findings should shed light on the pathogenesis of uterine fibroids.

AB - Uterine fibroids are a common benign tumor of the female genital tract. We conducted a genome-wide association study in which 457,044 SNPs were analyzed in 1,607 individuals with clinically diagnosed uterine fibroids and 1,428 female controls. SNPs showing suggestive associations (P < 5 × 10 -5) were further genotyped in 3,466 additional cases and 3,245 female controls. Three loci on chromosomes 10+24.33, 22+13.1 and 11+15.5 revealed genome-wide significant associations with uterine fibroids. The SNPs showing the most significant association in a combination analysis at each of these loci were rs7913069 (P = 8.65 × 10 -14, odds ratio (OR) = 1.47), rs12484776 (P = 2.79 × 10 -12, OR = 1.23) and rs2280543 (P = 3.82 × 10 -12, OR = 1.39), respectively. Subsequent fine mapping of these regions will be necessary to pinpoint the causal variants. Our findings should shed light on the pathogenesis of uterine fibroids.

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A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids

Abstract

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