A genome-wide association study identifies three new risk loci for Kawasaki disease

Yoshihiro Onouchi, Kouichi Ozaki, Jane C. Burns, Chisato Shimizu, Masaru Terai, Hiromichi Hamada, Takafumi Honda, Hiroyuki Suzuki, Tomohiro Suenaga, Takashi Takeuchi, Norishige Yoshikawa, Yoichi Suzuki, Kumi Yasukawa, Ryota Ebata, Kouji Higashi, Tsutomu Saji, Yasushi Kemmotsu, Shinichi Takatsuki, Kazunobu Ouchi, Fumio KishiTetsushi Yoshikawa, Toshiro Nagai, Kunihiro Hamamoto, Yoshitake Sato, Akihito Honda, Hironobu Kobayashi, Junichi Sato, Shoichi Shibuta, Masakazu Miyawaki, Ko Oishi, Hironobu Yamaga, Noriyuki Aoyagi, Seiji Iwahashi, Ritsuko Miyashita, Yuji Murata, Kumiko Sasago, Atsushi Takahashi, Naoyuki Kamatani, Michiaki Kubo, Tatsuhiko Tsunoda, Akira Hata, Yusuke Nakamura, Toshihiro Tanaka, Jun Abe, Tohru Kobayashi, Hirokazu Arakawa, Fukiko Ichida, Yuichi Nomura, Masaru Miura, Kazuyuki Ikeda, Toshiro Hara, Ryuji Fukazawa, Shunichi Ogawa, Kenji Hamaoka, Jane W. Newburger, Annette L. Baker, Anne H. Rowley, Stanford T. Shulman, Marian E. Melish, Wilbert H. Mason, Masato Takahashi, Adriana H. Tremoulet

Research output: Contribution to journalArticle

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Abstract

We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10 -21), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10 -11) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10 -8). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10 -6) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalNature Genetics
Volume44
Issue number5
DOIs
Publication statusPublished - 01-05-2012

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Mucocutaneous Lymph Node Syndrome
Genome-Wide Association Study
Single Nucleotide Polymorphism
HLA Antigens

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Onouchi, Y., Ozaki, K., Burns, J. C., Shimizu, C., Terai, M., Hamada, H., ... Tremoulet, A. H. (2012). A genome-wide association study identifies three new risk loci for Kawasaki disease. Nature Genetics, 44(5), 517-521. https://doi.org/10.1038/ng.2220
Onouchi, Yoshihiro ; Ozaki, Kouichi ; Burns, Jane C. ; Shimizu, Chisato ; Terai, Masaru ; Hamada, Hiromichi ; Honda, Takafumi ; Suzuki, Hiroyuki ; Suenaga, Tomohiro ; Takeuchi, Takashi ; Yoshikawa, Norishige ; Suzuki, Yoichi ; Yasukawa, Kumi ; Ebata, Ryota ; Higashi, Kouji ; Saji, Tsutomu ; Kemmotsu, Yasushi ; Takatsuki, Shinichi ; Ouchi, Kazunobu ; Kishi, Fumio ; Yoshikawa, Tetsushi ; Nagai, Toshiro ; Hamamoto, Kunihiro ; Sato, Yoshitake ; Honda, Akihito ; Kobayashi, Hironobu ; Sato, Junichi ; Shibuta, Shoichi ; Miyawaki, Masakazu ; Oishi, Ko ; Yamaga, Hironobu ; Aoyagi, Noriyuki ; Iwahashi, Seiji ; Miyashita, Ritsuko ; Murata, Yuji ; Sasago, Kumiko ; Takahashi, Atsushi ; Kamatani, Naoyuki ; Kubo, Michiaki ; Tsunoda, Tatsuhiko ; Hata, Akira ; Nakamura, Yusuke ; Tanaka, Toshihiro ; Abe, Jun ; Kobayashi, Tohru ; Arakawa, Hirokazu ; Ichida, Fukiko ; Nomura, Yuichi ; Miura, Masaru ; Ikeda, Kazuyuki ; Hara, Toshiro ; Fukazawa, Ryuji ; Ogawa, Shunichi ; Hamaoka, Kenji ; Newburger, Jane W. ; Baker, Annette L. ; Rowley, Anne H. ; Shulman, Stanford T. ; Melish, Marian E. ; Mason, Wilbert H. ; Takahashi, Masato ; Tremoulet, Adriana H. / A genome-wide association study identifies three new risk loci for Kawasaki disease. In: Nature Genetics. 2012 ; Vol. 44, No. 5. pp. 517-521.
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abstract = "We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10 -21), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10 -11) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10 -8). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10 -6) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease.",
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Onouchi, Y, Ozaki, K, Burns, JC, Shimizu, C, Terai, M, Hamada, H, Honda, T, Suzuki, H, Suenaga, T, Takeuchi, T, Yoshikawa, N, Suzuki, Y, Yasukawa, K, Ebata, R, Higashi, K, Saji, T, Kemmotsu, Y, Takatsuki, S, Ouchi, K, Kishi, F, Yoshikawa, T, Nagai, T, Hamamoto, K, Sato, Y, Honda, A, Kobayashi, H, Sato, J, Shibuta, S, Miyawaki, M, Oishi, K, Yamaga, H, Aoyagi, N, Iwahashi, S, Miyashita, R, Murata, Y, Sasago, K, Takahashi, A, Kamatani, N, Kubo, M, Tsunoda, T, Hata, A, Nakamura, Y, Tanaka, T, Abe, J, Kobayashi, T, Arakawa, H, Ichida, F, Nomura, Y, Miura, M, Ikeda, K, Hara, T, Fukazawa, R, Ogawa, S, Hamaoka, K, Newburger, JW, Baker, AL, Rowley, AH, Shulman, ST, Melish, ME, Mason, WH, Takahashi, M & Tremoulet, AH 2012, 'A genome-wide association study identifies three new risk loci for Kawasaki disease', Nature Genetics, vol. 44, no. 5, pp. 517-521. https://doi.org/10.1038/ng.2220

A genome-wide association study identifies three new risk loci for Kawasaki disease. / Onouchi, Yoshihiro; Ozaki, Kouichi; Burns, Jane C.; Shimizu, Chisato; Terai, Masaru; Hamada, Hiromichi; Honda, Takafumi; Suzuki, Hiroyuki; Suenaga, Tomohiro; Takeuchi, Takashi; Yoshikawa, Norishige; Suzuki, Yoichi; Yasukawa, Kumi; Ebata, Ryota; Higashi, Kouji; Saji, Tsutomu; Kemmotsu, Yasushi; Takatsuki, Shinichi; Ouchi, Kazunobu; Kishi, Fumio; Yoshikawa, Tetsushi; Nagai, Toshiro; Hamamoto, Kunihiro; Sato, Yoshitake; Honda, Akihito; Kobayashi, Hironobu; Sato, Junichi; Shibuta, Shoichi; Miyawaki, Masakazu; Oishi, Ko; Yamaga, Hironobu; Aoyagi, Noriyuki; Iwahashi, Seiji; Miyashita, Ritsuko; Murata, Yuji; Sasago, Kumiko; Takahashi, Atsushi; Kamatani, Naoyuki; Kubo, Michiaki; Tsunoda, Tatsuhiko; Hata, Akira; Nakamura, Yusuke; Tanaka, Toshihiro; Abe, Jun; Kobayashi, Tohru; Arakawa, Hirokazu; Ichida, Fukiko; Nomura, Yuichi; Miura, Masaru; Ikeda, Kazuyuki; Hara, Toshiro; Fukazawa, Ryuji; Ogawa, Shunichi; Hamaoka, Kenji; Newburger, Jane W.; Baker, Annette L.; Rowley, Anne H.; Shulman, Stanford T.; Melish, Marian E.; Mason, Wilbert H.; Takahashi, Masato; Tremoulet, Adriana H.

In: Nature Genetics, Vol. 44, No. 5, 01.05.2012, p. 517-521.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A genome-wide association study identifies three new risk loci for Kawasaki disease

AU - Onouchi, Yoshihiro

AU - Ozaki, Kouichi

AU - Burns, Jane C.

AU - Shimizu, Chisato

AU - Terai, Masaru

AU - Hamada, Hiromichi

AU - Honda, Takafumi

AU - Suzuki, Hiroyuki

AU - Suenaga, Tomohiro

AU - Takeuchi, Takashi

AU - Yoshikawa, Norishige

AU - Suzuki, Yoichi

AU - Yasukawa, Kumi

AU - Ebata, Ryota

AU - Higashi, Kouji

AU - Saji, Tsutomu

AU - Kemmotsu, Yasushi

AU - Takatsuki, Shinichi

AU - Ouchi, Kazunobu

AU - Kishi, Fumio

AU - Yoshikawa, Tetsushi

AU - Nagai, Toshiro

AU - Hamamoto, Kunihiro

AU - Sato, Yoshitake

AU - Honda, Akihito

AU - Kobayashi, Hironobu

AU - Sato, Junichi

AU - Shibuta, Shoichi

AU - Miyawaki, Masakazu

AU - Oishi, Ko

AU - Yamaga, Hironobu

AU - Aoyagi, Noriyuki

AU - Iwahashi, Seiji

AU - Miyashita, Ritsuko

AU - Murata, Yuji

AU - Sasago, Kumiko

AU - Takahashi, Atsushi

AU - Kamatani, Naoyuki

AU - Kubo, Michiaki

AU - Tsunoda, Tatsuhiko

AU - Hata, Akira

AU - Nakamura, Yusuke

AU - Tanaka, Toshihiro

AU - Abe, Jun

AU - Kobayashi, Tohru

AU - Arakawa, Hirokazu

AU - Ichida, Fukiko

AU - Nomura, Yuichi

AU - Miura, Masaru

AU - Ikeda, Kazuyuki

AU - Hara, Toshiro

AU - Fukazawa, Ryuji

AU - Ogawa, Shunichi

AU - Hamaoka, Kenji

AU - Newburger, Jane W.

AU - Baker, Annette L.

AU - Rowley, Anne H.

AU - Shulman, Stanford T.

AU - Melish, Marian E.

AU - Mason, Wilbert H.

AU - Takahashi, Masato

AU - Tremoulet, Adriana H.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10 -21), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10 -11) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10 -8). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10 -6) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease.

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Onouchi Y, Ozaki K, Burns JC, Shimizu C, Terai M, Hamada H et al. A genome-wide association study identifies three new risk loci for Kawasaki disease. Nature Genetics. 2012 May 1;44(5):517-521. https://doi.org/10.1038/ng.2220