Abstract
Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
Original language | English |
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Pages (from-to) | 900-903 |
Number of pages | 4 |
Journal | Nature Genetics |
Volume | 44 |
Issue number | 8 |
DOIs | |
Publication status | Published - 01-08-2012 |
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All Science Journal Classification (ASJC) codes
- Genetics
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A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. / Shiraishi, Kouya; Kunitoh, Hideo; Daigo, Yataro; Takahashi, Atsushi; Goto, Koichi; Sakamoto, Hiromi; Ohnami, Sumiko; Shimada, Yoko; Ashikawa, Kyota; Saito, Akira; Watanabe, Shun Ichi; Tsuta, Koji; Kamatani, Naoyuki; Yoshida, Teruhiko; Nakamura, Yusuke; Yokota, Jun; Kubo, Michiaki; Kohno, Takashi.
In: Nature Genetics, Vol. 44, No. 8, 01.08.2012, p. 900-903.Research output: Contribution to journal › Article
TY - JOUR
T1 - A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
AU - Shiraishi, Kouya
AU - Kunitoh, Hideo
AU - Daigo, Yataro
AU - Takahashi, Atsushi
AU - Goto, Koichi
AU - Sakamoto, Hiromi
AU - Ohnami, Sumiko
AU - Shimada, Yoko
AU - Ashikawa, Kyota
AU - Saito, Akira
AU - Watanabe, Shun Ichi
AU - Tsuta, Koji
AU - Kamatani, Naoyuki
AU - Yoshida, Teruhiko
AU - Nakamura, Yusuke
AU - Yokota, Jun
AU - Kubo, Michiaki
AU - Kohno, Takashi
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
AB - Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
UR - http://www.scopus.com/inward/record.url?scp=84864416630&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864416630&partnerID=8YFLogxK
U2 - 10.1038/ng.2353
DO - 10.1038/ng.2353
M3 - Article
C2 - 22797724
AN - SCOPUS:84864416630
VL - 44
SP - 900
EP - 903
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 8
ER -