A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

Kouya Shiraishi; Hideo Kunitoh; Yataro Daigo; Atsushi Takahashi; Koichi Goto; Hiromi Sakamoto; Sumiko Ohnami; Yoko Shimada; Kyota Ashikawa; Akira Saito; Shun Ichi Watanabe; Koji Tsuta; Naoyuki Kamatani; Teruhiko Yoshida; Yusuke Nakamura; Jun Yokota; Michiaki Kubo; Takashi Kohno

doi:10.1038/ng.2353

A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

Kouya Shiraishi, Hideo Kunitoh, Yataro Daigo, Atsushi Takahashi, Koichi Goto, Hiromi Sakamoto, Sumiko Ohnami, Yoko Shimada, Kyota Ashikawa, Akira Saito, Shun Ichi Watanabe, Koji Tsuta, Naoyuki Kamatani, Teruhiko Yoshida, Yusuke Nakamura, Jun Yokota, Michiaki Kubo, Takashi Kohno

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Abstract

Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P _combined = 2.8 × 10 ^-40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P _combined = 6.9 × 10 ^-17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P _combined = 7.4 × 10 ^-11, OR = 1.20) and 6p21.3 (rs3817963, P _combined = 2.7 × 10 ^-10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

Original language	English
Pages (from-to)	900-903
Number of pages	4
Journal	Nature Genetics
Volume	44
Issue number	8
DOIs	https://doi.org/10.1038/ng.2353
Publication status	Published - 08-2012

All Science Journal Classification (ASJC) codes

Genetics

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Shiraishi, K., Kunitoh, H., Daigo, Y., Takahashi, A., Goto, K., Sakamoto, H., Ohnami, S., Shimada, Y., Ashikawa, K., Saito, A., Watanabe, S. I., Tsuta, K., Kamatani, N., Yoshida, T., Nakamura, Y., Yokota, J., Kubo, M., & Kohno, T. (2012). A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nature Genetics, 44(8), 900-903. https://doi.org/10.1038/ng.2353

Shiraishi, Kouya ; Kunitoh, Hideo ; Daigo, Yataro ; Takahashi, Atsushi ; Goto, Koichi ; Sakamoto, Hiromi ; Ohnami, Sumiko ; Shimada, Yoko ; Ashikawa, Kyota ; Saito, Akira ; Watanabe, Shun Ichi ; Tsuta, Koji ; Kamatani, Naoyuki ; Yoshida, Teruhiko ; Nakamura, Yusuke ; Yokota, Jun ; Kubo, Michiaki ; Kohno, Takashi. / A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. In: Nature Genetics. 2012 ; Vol. 44, No. 8. pp. 900-903.

@article{52a1e8fcb1a34b86bb77d0e2de76259f,

title = "A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population",

abstract = "Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.",

author = "Kouya Shiraishi and Hideo Kunitoh and Yataro Daigo and Atsushi Takahashi and Koichi Goto and Hiromi Sakamoto and Sumiko Ohnami and Yoko Shimada and Kyota Ashikawa and Akira Saito and Watanabe, {Shun Ichi} and Koji Tsuta and Naoyuki Kamatani and Teruhiko Yoshida and Yusuke Nakamura and Jun Yokota and Michiaki Kubo and Takashi Kohno",

note = "Funding Information: We thank all of the subjects for participating in the study, and we also thank the collaborating physicians for assisting with sample collection. We are grateful to the members of BioBank Japan, the National Cancer Center Biobank and the Rotary Club of Osaka-Midosuji District 2660 Rotary International in Japan for supporting our study. We thank Y. Aoi, T. Odaka, M. Okuyama, H. Totsuka, S. Chiku, A. Kuchiba and the technical staff of the Center for Genome Medicine, National Cancer Center Research Institute, for providing technical and methodological assistance. We also thank H. Hirose of Health Center, Keio University and D. Saito of National Cancer Center Hospital (present affiliation: Nihonbashi Daizo Clinic) for DNA samples of control subjects. This work was supported in part by Grants-in-Aid from the Ministry of Health, Labor and Welfare for Research on Applying Health Technology and for the 3rd-term Comprehensive 10-year Strategy for Cancer Control; from the Ministry of Education, Culture, Sports, Science and Technology of Japan for Scientific Research on Innovative Areas (22131006); from the Japan Society for the Promotion of Science for Research Activity Start-up (23800073) and for Young Scientists (B) (24790340); and by the National Cancer Center Research and Development Fund. This work was also conducted as a part of the BioBank Japan Project supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan. The National Cancer Center Biobank is supported by the National Cancer Center Research and Development Fund, Japan.",

year = "2012",

month = aug,

doi = "10.1038/ng.2353",

language = "English",

volume = "44",

pages = "900--903",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

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Shiraishi, K, Kunitoh, H, Daigo, Y, Takahashi, A, Goto, K, Sakamoto, H, Ohnami, S, Shimada, Y, Ashikawa, K, Saito, A, Watanabe, SI, Tsuta, K, Kamatani, N, Yoshida, T, Nakamura, Y, Yokota, J, Kubo, M & Kohno, T 2012, 'A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population', Nature Genetics, vol. 44, no. 8, pp. 900-903. https://doi.org/10.1038/ng.2353

A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. / Shiraishi, Kouya; Kunitoh, Hideo; Daigo, Yataro; Takahashi, Atsushi; Goto, Koichi; Sakamoto, Hiromi; Ohnami, Sumiko; Shimada, Yoko; Ashikawa, Kyota; Saito, Akira; Watanabe, Shun Ichi; Tsuta, Koji; Kamatani, Naoyuki; Yoshida, Teruhiko; Nakamura, Yusuke; Yokota, Jun; Kubo, Michiaki; Kohno, Takashi.

In: Nature Genetics, Vol. 44, No. 8, 08.2012, p. 900-903.

Research output: Contribution to journal › Article › peer-review

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T1 - A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

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AU - Daigo, Yataro

AU - Takahashi, Atsushi

AU - Goto, Koichi

AU - Sakamoto, Hiromi

AU - Ohnami, Sumiko

AU - Shimada, Yoko

AU - Ashikawa, Kyota

AU - Saito, Akira

AU - Watanabe, Shun Ichi

AU - Tsuta, Koji

AU - Kamatani, Naoyuki

AU - Yoshida, Teruhiko

AU - Nakamura, Yusuke

AU - Yokota, Jun

AU - Kubo, Michiaki

AU - Kohno, Takashi

N1 - Funding Information: We thank all of the subjects for participating in the study, and we also thank the collaborating physicians for assisting with sample collection. We are grateful to the members of BioBank Japan, the National Cancer Center Biobank and the Rotary Club of Osaka-Midosuji District 2660 Rotary International in Japan for supporting our study. We thank Y. Aoi, T. Odaka, M. Okuyama, H. Totsuka, S. Chiku, A. Kuchiba and the technical staff of the Center for Genome Medicine, National Cancer Center Research Institute, for providing technical and methodological assistance. We also thank H. Hirose of Health Center, Keio University and D. Saito of National Cancer Center Hospital (present affiliation: Nihonbashi Daizo Clinic) for DNA samples of control subjects. This work was supported in part by Grants-in-Aid from the Ministry of Health, Labor and Welfare for Research on Applying Health Technology and for the 3rd-term Comprehensive 10-year Strategy for Cancer Control; from the Ministry of Education, Culture, Sports, Science and Technology of Japan for Scientific Research on Innovative Areas (22131006); from the Japan Society for the Promotion of Science for Research Activity Start-up (23800073) and for Young Scientists (B) (24790340); and by the National Cancer Center Research and Development Fund. This work was also conducted as a part of the BioBank Japan Project supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan. The National Cancer Center Biobank is supported by the National Cancer Center Research and Development Fund, Japan.

PY - 2012/8

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N2 - Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

AB - Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

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