A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

Kouya Shiraishi; Hideo Kunitoh; Yataro Daigo; Atsushi Takahashi; Koichi Goto; Hiromi Sakamoto; Sumiko Ohnami; Yoko Shimada; Kyota Ashikawa; Akira Saito; Shun Ichi Watanabe; Koji Tsuta; Naoyuki Kamatani; Teruhiko Yoshida; Yusuke Nakamura; Jun Yokota; Michiaki Kubo; Takashi Kohno

doi:10.1038/ng.2353

A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

Kouya Shiraishi, Hideo Kunitoh, Yataro Daigo, Atsushi Takahashi, Koichi Goto, Hiromi Sakamoto, Sumiko Ohnami, Yoko Shimada, Kyota Ashikawa, Akira Saito, Shun Ichi Watanabe, Koji Tsuta, Naoyuki Kamatani, Teruhiko Yoshida, Yusuke Nakamura, Jun Yokota, Michiaki Kubo, Takashi Kohno

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Abstract

Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P _combined = 2.8 × 10 ^-40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P _combined = 6.9 × 10 ^-17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P _combined = 7.4 × 10 ^-11, OR = 1.20) and 6p21.3 (rs3817963, P _combined = 2.7 × 10 ^-10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

Original language	English
Pages (from-to)	900-903
Number of pages	4
Journal	Nature Genetics
Volume	44
Issue number	8
DOIs	https://doi.org/10.1038/ng.2353
Publication status	Published - 08-2012

All Science Journal Classification (ASJC) codes

Genetics

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Shiraishi, K., Kunitoh, H., Daigo, Y., Takahashi, A., Goto, K., Sakamoto, H., Ohnami, S., Shimada, Y., Ashikawa, K., Saito, A., Watanabe, S. I., Tsuta, K., Kamatani, N., Yoshida, T., Nakamura, Y., Yokota, J., Kubo, M., & Kohno, T. (2012). A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nature Genetics, 44(8), 900-903. https://doi.org/10.1038/ng.2353

Shiraishi, Kouya ; Kunitoh, Hideo ; Daigo, Yataro ; Takahashi, Atsushi ; Goto, Koichi ; Sakamoto, Hiromi ; Ohnami, Sumiko ; Shimada, Yoko ; Ashikawa, Kyota ; Saito, Akira ; Watanabe, Shun Ichi ; Tsuta, Koji ; Kamatani, Naoyuki ; Yoshida, Teruhiko ; Nakamura, Yusuke ; Yokota, Jun ; Kubo, Michiaki ; Kohno, Takashi. / A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. In: Nature Genetics. 2012 ; Vol. 44, No. 8. pp. 900-903.

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title = "A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population",

abstract = "Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.",

author = "Kouya Shiraishi and Hideo Kunitoh and Yataro Daigo and Atsushi Takahashi and Koichi Goto and Hiromi Sakamoto and Sumiko Ohnami and Yoko Shimada and Kyota Ashikawa and Akira Saito and Watanabe, {Shun Ichi} and Koji Tsuta and Naoyuki Kamatani and Teruhiko Yoshida and Yusuke Nakamura and Jun Yokota and Michiaki Kubo and Takashi Kohno",

year = "2012",

month = aug,

doi = "10.1038/ng.2353",

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Shiraishi, K, Kunitoh, H, Daigo, Y, Takahashi, A, Goto, K, Sakamoto, H, Ohnami, S, Shimada, Y, Ashikawa, K, Saito, A, Watanabe, SI, Tsuta, K, Kamatani, N, Yoshida, T, Nakamura, Y, Yokota, J, Kubo, M & Kohno, T 2012, 'A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population', Nature Genetics, vol. 44, no. 8, pp. 900-903. https://doi.org/10.1038/ng.2353

A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. / Shiraishi, Kouya; Kunitoh, Hideo; Daigo, Yataro; Takahashi, Atsushi; Goto, Koichi; Sakamoto, Hiromi; Ohnami, Sumiko; Shimada, Yoko; Ashikawa, Kyota; Saito, Akira; Watanabe, Shun Ichi; Tsuta, Koji; Kamatani, Naoyuki; Yoshida, Teruhiko; Nakamura, Yusuke; Yokota, Jun; Kubo, Michiaki; Kohno, Takashi.

In: Nature Genetics, Vol. 44, No. 8, 08.2012, p. 900-903.

Research output: Contribution to journal › Article › peer-review

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T1 - A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

AU - Shiraishi, Kouya

AU - Kunitoh, Hideo

AU - Daigo, Yataro

AU - Takahashi, Atsushi

AU - Goto, Koichi

AU - Sakamoto, Hiromi

AU - Ohnami, Sumiko

AU - Shimada, Yoko

AU - Ashikawa, Kyota

AU - Saito, Akira

AU - Watanabe, Shun Ichi

AU - Tsuta, Koji

AU - Kamatani, Naoyuki

AU - Yoshida, Teruhiko

AU - Nakamura, Yusuke

AU - Yokota, Jun

AU - Kubo, Michiaki

AU - Kohno, Takashi

PY - 2012/8

Y1 - 2012/8

N2 - Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

AB - Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.

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