A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study

Hiroko Nakagawa-Senda, Tsuyoshi Hachiya, Atsushi Shimizu, Satoyo Hosono, Isao Oze, Miki Watanabe, Keitaro Matsuo, Hidemi Ito, Megumi Hara, Yuichiro Nishida, Kaori Endoh, Kiyonori Kuriki, Sakurako Katsuura-Kamano, Kokichi Arisawa, Yora Nindita, Rie Ibusuki, Sadao Suzuki, Akihiro Hosono, Haruo Mikami, Yohko NakamuraNaoyuki Takashima, Yasuyuki Nakamura, Nagato Kuriyama, Etsuko Ozaki, Norihiro Furusyo, Hiroaki Ikezaki, Masahiro Nakatochi, Tae Sasakabe, Sayo Kawai, Rieko Okada, Asahi Hishida, Mariko Naito, Kenji Wakai, Yukihide Momozawa, Michiaki Kubo, Hideo Tanaka

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6 Citations (Scopus)

Abstract

Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 × 10-6). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10-6), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10-16 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.

Original languageEnglish
Article number1493
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - 01-12-2018

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Genome-Wide Association Study
Coffee
Japan
Cohort Studies
Population
Meta-Analysis
Beverages
Genome
Health

All Science Journal Classification (ASJC) codes

  • General

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Nakagawa-Senda, Hiroko ; Hachiya, Tsuyoshi ; Shimizu, Atsushi ; Hosono, Satoyo ; Oze, Isao ; Watanabe, Miki ; Matsuo, Keitaro ; Ito, Hidemi ; Hara, Megumi ; Nishida, Yuichiro ; Endoh, Kaori ; Kuriki, Kiyonori ; Katsuura-Kamano, Sakurako ; Arisawa, Kokichi ; Nindita, Yora ; Ibusuki, Rie ; Suzuki, Sadao ; Hosono, Akihiro ; Mikami, Haruo ; Nakamura, Yohko ; Takashima, Naoyuki ; Nakamura, Yasuyuki ; Kuriyama, Nagato ; Ozaki, Etsuko ; Furusyo, Norihiro ; Ikezaki, Hiroaki ; Nakatochi, Masahiro ; Sasakabe, Tae ; Kawai, Sayo ; Okada, Rieko ; Hishida, Asahi ; Naito, Mariko ; Wakai, Kenji ; Momozawa, Yukihide ; Kubo, Michiaki ; Tanaka, Hideo. / A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption : The J-MICC Study. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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title = "A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study",
abstract = "Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 × 10-6). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10-6), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10-16 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.",
author = "Hiroko Nakagawa-Senda and Tsuyoshi Hachiya and Atsushi Shimizu and Satoyo Hosono and Isao Oze and Miki Watanabe and Keitaro Matsuo and Hidemi Ito and Megumi Hara and Yuichiro Nishida and Kaori Endoh and Kiyonori Kuriki and Sakurako Katsuura-Kamano and Kokichi Arisawa and Yora Nindita and Rie Ibusuki and Sadao Suzuki and Akihiro Hosono and Haruo Mikami and Yohko Nakamura and Naoyuki Takashima and Yasuyuki Nakamura and Nagato Kuriyama and Etsuko Ozaki and Norihiro Furusyo and Hiroaki Ikezaki and Masahiro Nakatochi and Tae Sasakabe and Sayo Kawai and Rieko Okada and Asahi Hishida and Mariko Naito and Kenji Wakai and Yukihide Momozawa and Michiaki Kubo and Hideo Tanaka",
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Nakagawa-Senda, H, Hachiya, T, Shimizu, A, Hosono, S, Oze, I, Watanabe, M, Matsuo, K, Ito, H, Hara, M, Nishida, Y, Endoh, K, Kuriki, K, Katsuura-Kamano, S, Arisawa, K, Nindita, Y, Ibusuki, R, Suzuki, S, Hosono, A, Mikami, H, Nakamura, Y, Takashima, N, Nakamura, Y, Kuriyama, N, Ozaki, E, Furusyo, N, Ikezaki, H, Nakatochi, M, Sasakabe, T, Kawai, S, Okada, R, Hishida, A, Naito, M, Wakai, K, Momozawa, Y, Kubo, M & Tanaka, H 2018, 'A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study', Scientific reports, vol. 8, no. 1, 1493. https://doi.org/10.1038/s41598-018-19914-w

A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption : The J-MICC Study. / Nakagawa-Senda, Hiroko; Hachiya, Tsuyoshi; Shimizu, Atsushi; Hosono, Satoyo; Oze, Isao; Watanabe, Miki; Matsuo, Keitaro; Ito, Hidemi; Hara, Megumi; Nishida, Yuichiro; Endoh, Kaori; Kuriki, Kiyonori; Katsuura-Kamano, Sakurako; Arisawa, Kokichi; Nindita, Yora; Ibusuki, Rie; Suzuki, Sadao; Hosono, Akihiro; Mikami, Haruo; Nakamura, Yohko; Takashima, Naoyuki; Nakamura, Yasuyuki; Kuriyama, Nagato; Ozaki, Etsuko; Furusyo, Norihiro; Ikezaki, Hiroaki; Nakatochi, Masahiro; Sasakabe, Tae; Kawai, Sayo; Okada, Rieko; Hishida, Asahi; Naito, Mariko; Wakai, Kenji; Momozawa, Yukihide; Kubo, Michiaki; Tanaka, Hideo.

In: Scientific reports, Vol. 8, No. 1, 1493, 01.12.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption

T2 - The J-MICC Study

AU - Nakagawa-Senda, Hiroko

AU - Hachiya, Tsuyoshi

AU - Shimizu, Atsushi

AU - Hosono, Satoyo

AU - Oze, Isao

AU - Watanabe, Miki

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Hara, Megumi

AU - Nishida, Yuichiro

AU - Endoh, Kaori

AU - Kuriki, Kiyonori

AU - Katsuura-Kamano, Sakurako

AU - Arisawa, Kokichi

AU - Nindita, Yora

AU - Ibusuki, Rie

AU - Suzuki, Sadao

AU - Hosono, Akihiro

AU - Mikami, Haruo

AU - Nakamura, Yohko

AU - Takashima, Naoyuki

AU - Nakamura, Yasuyuki

AU - Kuriyama, Nagato

AU - Ozaki, Etsuko

AU - Furusyo, Norihiro

AU - Ikezaki, Hiroaki

AU - Nakatochi, Masahiro

AU - Sasakabe, Tae

AU - Kawai, Sayo

AU - Okada, Rieko

AU - Hishida, Asahi

AU - Naito, Mariko

AU - Wakai, Kenji

AU - Momozawa, Yukihide

AU - Kubo, Michiaki

AU - Tanaka, Hideo

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 × 10-6). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10-6), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10-16 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.

AB - Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 × 10-6). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10-6), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10-16 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.

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