A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Toshimasa Yamauchi, Kazuo Hara, Shiro Maeda, Kazuki Yasuda, Atsushi Takahashi, Momoko Horikoshi, Masahiro Nakamura, Hayato Fujita, Niels Grarup, Stephane Cauchi, Daniel P.K. Ng, Ronald C.W. Ma, Tatsuhiko Tsunoda, Michiaki Kubo, Hirotaka Watada, Hiroshi Maegawa, Miki Okada-Iwabu, Masato Iwabu, Nobuhiro Shojima, Hyoung Doo Shin & 26 others Gitte Andersen, Daniel R. Witte, Torben Jørgensen, Torsten Lauritzen, Annelli Sandbæk, Torben Hansen, Toshihiko Ohshige, Shintaro Omori, Ikuo Saito, Kohei Kaku, Hiroshi Hirose, Wing Yee So, Delphine Beury, Juliana C.N. Chan, Kyong Soo Park, E. Shyong Tai, Chikako Ito, Yasushi Tanaka, Atsunori Kashiwagi, Ryuzo Kawamori, Masato Kasuga, Philippe Froguel, Oluf Pedersen, Naoyuki Kamatani, Yusuke Nakamura, Takashi Kadowaki

Research output: Contribution to journalArticle

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Abstract

We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10 -9; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10 -9). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10 -14, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.

Original languageEnglish
Pages (from-to)864-868
Number of pages5
JournalNature Genetics
Volume42
Issue number10
DOIs
Publication statusPublished - 01-10-2010

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Genome-Wide Association Study
Type 2 Diabetes Mellitus
Population
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 3
Single Nucleotide Polymorphism
Genome

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Yamauchi, T., Hara, K., Maeda, S., Yasuda, K., Takahashi, A., Horikoshi, M., ... Kadowaki, T. (2010). A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature Genetics, 42(10), 864-868. https://doi.org/10.1038/ng.660
Yamauchi, Toshimasa ; Hara, Kazuo ; Maeda, Shiro ; Yasuda, Kazuki ; Takahashi, Atsushi ; Horikoshi, Momoko ; Nakamura, Masahiro ; Fujita, Hayato ; Grarup, Niels ; Cauchi, Stephane ; Ng, Daniel P.K. ; Ma, Ronald C.W. ; Tsunoda, Tatsuhiko ; Kubo, Michiaki ; Watada, Hirotaka ; Maegawa, Hiroshi ; Okada-Iwabu, Miki ; Iwabu, Masato ; Shojima, Nobuhiro ; Shin, Hyoung Doo ; Andersen, Gitte ; Witte, Daniel R. ; Jørgensen, Torben ; Lauritzen, Torsten ; Sandbæk, Annelli ; Hansen, Torben ; Ohshige, Toshihiko ; Omori, Shintaro ; Saito, Ikuo ; Kaku, Kohei ; Hirose, Hiroshi ; So, Wing Yee ; Beury, Delphine ; Chan, Juliana C.N. ; Park, Kyong Soo ; Tai, E. Shyong ; Ito, Chikako ; Tanaka, Yasushi ; Kashiwagi, Atsunori ; Kawamori, Ryuzo ; Kasuga, Masato ; Froguel, Philippe ; Pedersen, Oluf ; Kamatani, Naoyuki ; Nakamura, Yusuke ; Kadowaki, Takashi. / A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. In: Nature Genetics. 2010 ; Vol. 42, No. 10. pp. 864-868.
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abstract = "We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10 -9; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10 -9). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10 -14, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.",
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Yamauchi, T, Hara, K, Maeda, S, Yasuda, K, Takahashi, A, Horikoshi, M, Nakamura, M, Fujita, H, Grarup, N, Cauchi, S, Ng, DPK, Ma, RCW, Tsunoda, T, Kubo, M, Watada, H, Maegawa, H, Okada-Iwabu, M, Iwabu, M, Shojima, N, Shin, HD, Andersen, G, Witte, DR, Jørgensen, T, Lauritzen, T, Sandbæk, A, Hansen, T, Ohshige, T, Omori, S, Saito, I, Kaku, K, Hirose, H, So, WY, Beury, D, Chan, JCN, Park, KS, Tai, ES, Ito, C, Tanaka, Y, Kashiwagi, A, Kawamori, R, Kasuga, M, Froguel, P, Pedersen, O, Kamatani, N, Nakamura, Y & Kadowaki, T 2010, 'A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B', Nature Genetics, vol. 42, no. 10, pp. 864-868. https://doi.org/10.1038/ng.660

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. / Yamauchi, Toshimasa; Hara, Kazuo; Maeda, Shiro; Yasuda, Kazuki; Takahashi, Atsushi; Horikoshi, Momoko; Nakamura, Masahiro; Fujita, Hayato; Grarup, Niels; Cauchi, Stephane; Ng, Daniel P.K.; Ma, Ronald C.W.; Tsunoda, Tatsuhiko; Kubo, Michiaki; Watada, Hirotaka; Maegawa, Hiroshi; Okada-Iwabu, Miki; Iwabu, Masato; Shojima, Nobuhiro; Shin, Hyoung Doo; Andersen, Gitte; Witte, Daniel R.; Jørgensen, Torben; Lauritzen, Torsten; Sandbæk, Annelli; Hansen, Torben; Ohshige, Toshihiko; Omori, Shintaro; Saito, Ikuo; Kaku, Kohei; Hirose, Hiroshi; So, Wing Yee; Beury, Delphine; Chan, Juliana C.N.; Park, Kyong Soo; Tai, E. Shyong; Ito, Chikako; Tanaka, Yasushi; Kashiwagi, Atsunori; Kawamori, Ryuzo; Kasuga, Masato; Froguel, Philippe; Pedersen, Oluf; Kamatani, Naoyuki; Nakamura, Yusuke; Kadowaki, Takashi.

In: Nature Genetics, Vol. 42, No. 10, 01.10.2010, p. 864-868.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

AU - Yamauchi, Toshimasa

AU - Hara, Kazuo

AU - Maeda, Shiro

AU - Yasuda, Kazuki

AU - Takahashi, Atsushi

AU - Horikoshi, Momoko

AU - Nakamura, Masahiro

AU - Fujita, Hayato

AU - Grarup, Niels

AU - Cauchi, Stephane

AU - Ng, Daniel P.K.

AU - Ma, Ronald C.W.

AU - Tsunoda, Tatsuhiko

AU - Kubo, Michiaki

AU - Watada, Hirotaka

AU - Maegawa, Hiroshi

AU - Okada-Iwabu, Miki

AU - Iwabu, Masato

AU - Shojima, Nobuhiro

AU - Shin, Hyoung Doo

AU - Andersen, Gitte

AU - Witte, Daniel R.

AU - Jørgensen, Torben

AU - Lauritzen, Torsten

AU - Sandbæk, Annelli

AU - Hansen, Torben

AU - Ohshige, Toshihiko

AU - Omori, Shintaro

AU - Saito, Ikuo

AU - Kaku, Kohei

AU - Hirose, Hiroshi

AU - So, Wing Yee

AU - Beury, Delphine

AU - Chan, Juliana C.N.

AU - Park, Kyong Soo

AU - Tai, E. Shyong

AU - Ito, Chikako

AU - Tanaka, Yasushi

AU - Kashiwagi, Atsunori

AU - Kawamori, Ryuzo

AU - Kasuga, Masato

AU - Froguel, Philippe

AU - Pedersen, Oluf

AU - Kamatani, Naoyuki

AU - Nakamura, Yusuke

AU - Kadowaki, Takashi

PY - 2010/10/1

Y1 - 2010/10/1

N2 - We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10 -9; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10 -9). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10 -14, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.

AB - We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10 -9; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10 -9). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10 -14, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.

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