TY - JOUR
T1 - A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression
AU - Shimanoe, C.
AU - Hachiya, T.
AU - Hara, M.
AU - Nishida, Y.
AU - Tanaka, K.
AU - Sutoh, Y.
AU - Shimizu, A.
AU - Hishida, A.
AU - Kawai, S.
AU - Okada, R.
AU - Tamura, T.
AU - Matsuo, K.
AU - Ito, H.
AU - Ozaki, E.
AU - Matsui, D.
AU - Ibusuki, R.
AU - Shimoshikiryo, I.
AU - Takashima, N.
AU - Kadota, A.
AU - Arisawa, K.
AU - Uemura, H.
AU - Suzuki, S.
AU - Watanabe, M.
AU - Kuriki, K.
AU - Endoh, K.
AU - Mikami, H.
AU - Nakamura, Y.
AU - Momozawa, Y.
AU - Kubo, M.
AU - Nakatochi, M.
AU - Naito, M.
AU - Wakai, K.
N1 - Funding Information:
information Grants-in-Aid for Scientific Research for Innovative Areas, Grant/Award Number: 221S0001; Grants-in-Aid for Scientific Research for Priority Areas of Cancer, Grant/Award Number: 17015018; JSPS KAKENHI Grant, Grant/Award Number: JP15H02524JP15K01718JP16H06277; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and DevelopmentThis study was supported by Grants-in-Aid for Scientific Research for Priority Areas of Cancer (No. 17015018) and Innovative Areas (No. 221S0001) and by JSPS KAKENHI Grant Numbers JP15H02524, JP16H06277 and JP15K01718 from the Japanese Ministry of Education, Culture, Sports, Science and Technology. This study was supported in part by funding for the BioBank Japan Project from the Japan Agency for Medical Research and Development since April 2015, and the Ministry of Education, Culture, Sports, Science and Technology from April 2003 to March 2015. The authors declare that we have no conflict of interest.
Funding Information:
This study was supported by Grants-in-Aid for Scientific Research for Priority Areas of Cancer (No. 17015018) and Innovative Areas (No. 221S0001) and by JSPS KAKENHI Grant Numbers JP15H02524, JP16H06277 and JP15K01718 from the Japanese Ministry of Education, Culture, Sports, Science and Technology. This study was supported in part by funding for the BioBank Japan Project from the Japan Agency for Medical Research and Development since April 2015, and the Ministry of Education, Culture, Sports, Science and Technology from April 2003 to March 2015.
Publisher Copyright:
© 2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society
PY - 2019/2
Y1 - 2019/2
N2 - Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10−6) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10−6). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.
AB - Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10−6) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10−6). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.
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U2 - 10.1111/gbb.12481
DO - 10.1111/gbb.12481
M3 - Article
C2 - 29665250
AN - SCOPUS:85046708861
VL - 18
JO - Genes, Brain and Behavior
JF - Genes, Brain and Behavior
SN - 1601-1848
IS - 2
M1 - e12481
ER -