Abstract
Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10 −6 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10 −6 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.
| Original language | English |
|---|---|
| Article number | e12481 |
| Journal | Genes, Brain and Behavior |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 01-02-2019 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Genetics
- Neurology
- Behavioral Neuroscience
Cite this
}
A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression. / Shimanoe, C.; Hachiya, T.; Hara, M.; Nishida, Y.; Tanaka, K.; Sutoh, Y.; Shimizu, A.; Hishida, A.; Kawai, S.; Okada, R.; Tamura, T.; Matsuo, K.; Ito, H.; Ozaki, E.; Matsui, D.; Ibusuki, R.; Shimoshikiryo, I.; Takashima, N.; Kadota, A.; Arisawa, K.; Uemura, H.; Suzuki, S.; Watanabe, M.; Kuriki, K.; Endoh, K.; Mikami, H.; Nakamura, Y.; Momozawa, Y.; Kubo, M.; Nakatochi, M.; Naito, M.; Wakai, K.
In: Genes, Brain and Behavior, Vol. 18, No. 2, e12481, 01.02.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression
AU - Shimanoe, C.
AU - Hachiya, T.
AU - Hara, M.
AU - Nishida, Y.
AU - Tanaka, K.
AU - Sutoh, Y.
AU - Shimizu, A.
AU - Hishida, A.
AU - Kawai, S.
AU - Okada, R.
AU - Tamura, T.
AU - Matsuo, K.
AU - Ito, H.
AU - Ozaki, E.
AU - Matsui, D.
AU - Ibusuki, R.
AU - Shimoshikiryo, I.
AU - Takashima, N.
AU - Kadota, A.
AU - Arisawa, K.
AU - Uemura, H.
AU - Suzuki, S.
AU - Watanabe, M.
AU - Kuriki, K.
AU - Endoh, K.
AU - Mikami, H.
AU - Nakamura, Y.
AU - Momozawa, Y.
AU - Kubo, M.
AU - Nakatochi, M.
AU - Naito, M.
AU - Wakai, K.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10 −6 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10 −6 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.
AB - Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10 −6 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10 −6 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.
UR - http://www.scopus.com/inward/record.url?scp=85046708861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046708861&partnerID=8YFLogxK
U2 - 10.1111/gbb.12481
DO - 10.1111/gbb.12481
M3 - Article
C2 - 29665250
AN - SCOPUS:85046708861
VL - 18
JO - Genes, Brain and Behavior
JF - Genes, Brain and Behavior
SN - 1601-1848
IS - 2
M1 - e12481
ER -