A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

Atsushi Hirano, Tomoyuki Ohara, Atsushi Takahashi, Masayuki Aoki, Yuta Fuyuno, Kyota Ashikawa, Takashi Morihara, Masatoshi Takeda, Kouzin Kamino, Etsuko Oshima, Yuko Okahisa, Nobuto Shibata, Heii Arai, Hiroyasu Akatsu, Masashi Ikeda, Nakao Iwata, Toshiharu Ninomiya, Akira Monji, Takanari Kitazono, Yutaka Kiyohara & 2 others Michiaki Kubo, Shigenobu Kanba

Research output: Contribution to journalArticle

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Abstract

Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10-7), CNTNAP2 (rs802571, P= 1.26×10-6), and 12q24.23 (rs11613092, P =6.85×10-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalPsychiatric Genetics
Volume25
Issue number4
DOIs
Publication statusPublished - 01-08-2015

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Genome-Wide Association Study
Alzheimer Disease
Population
Introns

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hirano, A., Ohara, T., Takahashi, A., Aoki, M., Fuyuno, Y., Ashikawa, K., ... Kanba, S. (2015). A genome-wide association study of late-onset Alzheimer's disease in a Japanese population. Psychiatric Genetics, 25(4), 139-146. https://doi.org/10.1097/YPG.0000000000000090
Hirano, Atsushi ; Ohara, Tomoyuki ; Takahashi, Atsushi ; Aoki, Masayuki ; Fuyuno, Yuta ; Ashikawa, Kyota ; Morihara, Takashi ; Takeda, Masatoshi ; Kamino, Kouzin ; Oshima, Etsuko ; Okahisa, Yuko ; Shibata, Nobuto ; Arai, Heii ; Akatsu, Hiroyasu ; Ikeda, Masashi ; Iwata, Nakao ; Ninomiya, Toshiharu ; Monji, Akira ; Kitazono, Takanari ; Kiyohara, Yutaka ; Kubo, Michiaki ; Kanba, Shigenobu. / A genome-wide association study of late-onset Alzheimer's disease in a Japanese population. In: Psychiatric Genetics. 2015 ; Vol. 25, No. 4. pp. 139-146.
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abstract = "Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10-7), CNTNAP2 (rs802571, P= 1.26×10-6), and 12q24.23 (rs11613092, P =6.85×10-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.",
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Hirano, A, Ohara, T, Takahashi, A, Aoki, M, Fuyuno, Y, Ashikawa, K, Morihara, T, Takeda, M, Kamino, K, Oshima, E, Okahisa, Y, Shibata, N, Arai, H, Akatsu, H, Ikeda, M, Iwata, N, Ninomiya, T, Monji, A, Kitazono, T, Kiyohara, Y, Kubo, M & Kanba, S 2015, 'A genome-wide association study of late-onset Alzheimer's disease in a Japanese population', Psychiatric Genetics, vol. 25, no. 4, pp. 139-146. https://doi.org/10.1097/YPG.0000000000000090

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population. / Hirano, Atsushi; Ohara, Tomoyuki; Takahashi, Atsushi; Aoki, Masayuki; Fuyuno, Yuta; Ashikawa, Kyota; Morihara, Takashi; Takeda, Masatoshi; Kamino, Kouzin; Oshima, Etsuko; Okahisa, Yuko; Shibata, Nobuto; Arai, Heii; Akatsu, Hiroyasu; Ikeda, Masashi; Iwata, Nakao; Ninomiya, Toshiharu; Monji, Akira; Kitazono, Takanari; Kiyohara, Yutaka; Kubo, Michiaki; Kanba, Shigenobu.

In: Psychiatric Genetics, Vol. 25, No. 4, 01.08.2015, p. 139-146.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

AU - Hirano, Atsushi

AU - Ohara, Tomoyuki

AU - Takahashi, Atsushi

AU - Aoki, Masayuki

AU - Fuyuno, Yuta

AU - Ashikawa, Kyota

AU - Morihara, Takashi

AU - Takeda, Masatoshi

AU - Kamino, Kouzin

AU - Oshima, Etsuko

AU - Okahisa, Yuko

AU - Shibata, Nobuto

AU - Arai, Heii

AU - Akatsu, Hiroyasu

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Ninomiya, Toshiharu

AU - Monji, Akira

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

AU - Kubo, Michiaki

AU - Kanba, Shigenobu

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10-7), CNTNAP2 (rs802571, P= 1.26×10-6), and 12q24.23 (rs11613092, P =6.85×10-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.

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