A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

Atsushi Hirano; Tomoyuki Ohara; Atsushi Takahashi; Masayuki Aoki; Yuta Fuyuno; Kyota Ashikawa; Takashi Morihara; Masatoshi Takeda; Kouzin Kamino; Etsuko Oshima; Yuko Okahisa; Nobuto Shibata; Heii Arai; Hiroyasu Akatsu; Masashi Ikeda; Nakao Iwata; Toshiharu Ninomiya; Akira Monji; Takanari Kitazono; Yutaka Kiyohara; Michiaki Kubo; Shigenobu Kanba

doi:10.1097/YPG.0000000000000090

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

Atsushi Hirano
, Tomoyuki Ohara
, Atsushi Takahashi
, Masayuki Aoki
, Yuta Fuyuno
, Kyota Ashikawa
, Takashi Morihara
, Masatoshi Takeda
, Kouzin Kamino
, Etsuko Oshima
, Yuko Okahisa
, Nobuto Shibata
, Heii Arai
, Hiroyasu Akatsu
, Masashi Ikeda
, Nakao Iwata
, Toshiharu Ninomiya
, Akira Monji
, Takanari Kitazono
, Yutaka Kiyohara

Michiaki Kubo, Shigenobu Kanba

visiting faculty

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10^-7), CNTNAP2 (rs802571, P= 1.26×10^-6), and 12q24.23 (rs11613092, P =6.85×10^-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.

Original language	English
Pages (from-to)	139-146
Number of pages	8
Journal	Psychiatric Genetics
Volume	25
Issue number	4
DOIs	https://doi.org/10.1097/YPG.0000000000000090
Publication status	Published - 01-08-2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

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10.1097/YPG.0000000000000090

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Hirano, A., Ohara, T., Takahashi, A., Aoki, M., Fuyuno, Y., Ashikawa, K., Morihara, T., Takeda, M., Kamino, K., Oshima, E., Okahisa, Y., Shibata, N., Arai, H., Akatsu, H., Ikeda, M., Iwata, N., Ninomiya, T., Monji, A., Kitazono, T., ... Kanba, S. (2015). A genome-wide association study of late-onset Alzheimer's disease in a Japanese population. Psychiatric Genetics, 25(4), 139-146. https://doi.org/10.1097/YPG.0000000000000090

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title = "A genome-wide association study of late-onset Alzheimer's disease in a Japanese population",

abstract = "Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10-7), CNTNAP2 (rs802571, P= 1.26×10-6), and 12q24.23 (rs11613092, P =6.85×10-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.",

author = "Atsushi Hirano and Tomoyuki Ohara and Atsushi Takahashi and Masayuki Aoki and Yuta Fuyuno and Kyota Ashikawa and Takashi Morihara and Masatoshi Takeda and Kouzin Kamino and Etsuko Oshima and Yuko Okahisa and Nobuto Shibata and Heii Arai and Hiroyasu Akatsu and Masashi Ikeda and Nakao Iwata and Toshiharu Ninomiya and Akira Monji and Takanari Kitazono and Yutaka Kiyohara and Michiaki Kubo and Shigenobu Kanba",

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Hirano, A, Ohara, T, Takahashi, A, Aoki, M, Fuyuno, Y, Ashikawa, K, Morihara, T, Takeda, M, Kamino, K, Oshima, E, Okahisa, Y, Shibata, N, Arai, H, Akatsu, H, Ikeda, M, Iwata, N, Ninomiya, T, Monji, A, Kitazono, T, Kiyohara, Y, Kubo, M & Kanba, S 2015, 'A genome-wide association study of late-onset Alzheimer's disease in a Japanese population', Psychiatric Genetics, vol. 25, no. 4, pp. 139-146. https://doi.org/10.1097/YPG.0000000000000090

TY - JOUR

T1 - A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

AU - Hirano, Atsushi

AU - Ohara, Tomoyuki

AU - Takahashi, Atsushi

AU - Aoki, Masayuki

AU - Fuyuno, Yuta

AU - Ashikawa, Kyota

AU - Morihara, Takashi

AU - Takeda, Masatoshi

AU - Kamino, Kouzin

AU - Oshima, Etsuko

AU - Okahisa, Yuko

AU - Shibata, Nobuto

AU - Arai, Heii

AU - Akatsu, Hiroyasu

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Ninomiya, Toshiharu

AU - Monji, Akira

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

AU - Kubo, Michiaki

AU - Kanba, Shigenobu

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10-7), CNTNAP2 (rs802571, P= 1.26×10-6), and 12q24.23 (rs11613092, P =6.85×10-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.

AB - Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10-7), CNTNAP2 (rs802571, P= 1.26×10-6), and 12q24.23 (rs11613092, P =6.85×10-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.

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U2 - 10.1097/YPG.0000000000000090

DO - 10.1097/YPG.0000000000000090

M3 - Article

C2 - 26049409

AN - SCOPUS:84942565964

SN - 0955-8829

VL - 25

SP - 139

EP - 146

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 4

ER -

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

Abstract

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