A genome-wide association study of periodontitis in a Japanese population

S. Shimizu, Y. Momozawa, A. Takahashi, T. Nagasawa, K. Ashikawa, Y. Terada, Y. Izumi, H. Kobayashi, M. Tsuji, Michiaki Kubo, Y. Furuichi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Periodontitis is a multifactorial disease in which bacterial, lifestyle, and genetic factors are involved. Although previous genetic association studies identified several susceptibility genes for periodontitis in European populations, there is little information for Asian populations. Here, we conducted a genome-wide association study and a replication study consisting of 2,760 Japanese periodontitis patients and 15,158 Japanese controls. Although single-nucleotide polymorphisms that surpassed a stringent genome-wide significance threshold (P < 5 × 10-8) were not identified, we found 2 suggestive loci for periodontitis: KCNQ5 on chromosome 6q13 (rs9446777, P = 4.83 × 10-6, odds ratio = 0.82) and GPR141-NME8 at chromosome 7p14.1 (rs2392510, P = 4.17 × 10-6, odds ratio = 0.87). A stratified analysis indicated that the GPR141-NME8 locus had a strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with a history of smoking. In conclusion, this study identified 2 suggestive loci for periodontitis in a Japanese population. This study should contribute to a further understanding of genetic factors for enhanced susceptibility to periodontitis.

Original languageEnglish
Pages (from-to)555-561
Number of pages7
JournalJournal of Dental Research
Volume94
Issue number4
DOIs
Publication statusPublished - 01-01-2015
Externally publishedYes

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Periodontitis
Genome-Wide Association Study
Population
Chromosomes
Odds Ratio
Genetic Association Studies
Single Nucleotide Polymorphism
Life Style
Smoking
Genome
Genes

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Shimizu, S., Momozawa, Y., Takahashi, A., Nagasawa, T., Ashikawa, K., Terada, Y., ... Furuichi, Y. (2015). A genome-wide association study of periodontitis in a Japanese population. Journal of Dental Research, 94(4), 555-561. https://doi.org/10.1177/0022034515570315
Shimizu, S. ; Momozawa, Y. ; Takahashi, A. ; Nagasawa, T. ; Ashikawa, K. ; Terada, Y. ; Izumi, Y. ; Kobayashi, H. ; Tsuji, M. ; Kubo, Michiaki ; Furuichi, Y. / A genome-wide association study of periodontitis in a Japanese population. In: Journal of Dental Research. 2015 ; Vol. 94, No. 4. pp. 555-561.
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Shimizu, S, Momozawa, Y, Takahashi, A, Nagasawa, T, Ashikawa, K, Terada, Y, Izumi, Y, Kobayashi, H, Tsuji, M, Kubo, M & Furuichi, Y 2015, 'A genome-wide association study of periodontitis in a Japanese population', Journal of Dental Research, vol. 94, no. 4, pp. 555-561. https://doi.org/10.1177/0022034515570315

A genome-wide association study of periodontitis in a Japanese population. / Shimizu, S.; Momozawa, Y.; Takahashi, A.; Nagasawa, T.; Ashikawa, K.; Terada, Y.; Izumi, Y.; Kobayashi, H.; Tsuji, M.; Kubo, Michiaki; Furuichi, Y.

In: Journal of Dental Research, Vol. 94, No. 4, 01.01.2015, p. 555-561.

Research output: Contribution to journalArticle

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Shimizu S, Momozawa Y, Takahashi A, Nagasawa T, Ashikawa K, Terada Y et al. A genome-wide association study of periodontitis in a Japanese population. Journal of Dental Research. 2015 Jan 1;94(4):555-561. https://doi.org/10.1177/0022034515570315