A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population

Kyong Ah Yoon, Jae Hee Park, Jihye Han, Sohee Park, Geon Kook Lee, Ji Youn Han, Jae Ill Zo, Jeongseon Kim, Jong Eun Lee, Atsushi Takahashi, Michiaki Kubo, Yusuke Nakamura, Jin Soo Lee

Research output: Contribution to journalArticle

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Abstract

Lung cancer is one of the most common cancers and the major cause of cancer death, both in Korea and worldwide, with non-small cell lung cancer (NSCLC) as the predominant histologic type. To identify genetic risk factors, we here conducted a genome-wide association study (GWAS) and a replication study in 1425 patients with NSCLC and 3011 controls from Korea. From the data for 2162 participants analyzed using the Affymetrix Genome-wide Human SNP array 5.0K, 168 single nucleotide polymorphisms (SNPs) were selected for validation. In the second stage, we were able to genotype 168 SNPs in 804 patients and 1470 controls to confirm the results of the GWAS. In the meta-analysis, rs2131877 at the chromosome 3q29 region was the most significant biomarker of lung cancer susceptibility in Koreans (P = 2.43 × 10 -8 ). Four markers that were located within the chromosome 3q29 region were also associated with lung cancer susceptibility (trend P < 1.2 × 10 -4 ), along with markers on 5p15 that were previously reported in populations of European descent. This high-density large-scale GWAS carried out in the Korean population suggests that 3q29 is a novel susceptibility region associated with lung cancer susceptibility in Koreans.

Original languageEnglish
Article numberddq421
Pages (from-to)4948-4954
Number of pages7
JournalHuman molecular genetics
Volume19
Issue number24
DOIs
Publication statusPublished - 01-12-2010

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Genome-Wide Association Study
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Single Nucleotide Polymorphism
Korea
Population
Chromosomes
Human Genome
Meta-Analysis
Cause of Death
Neoplasms
Biomarkers
Genotype

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Yoon, K. A., Park, J. H., Han, J., Park, S., Lee, G. K., Han, J. Y., ... Lee, J. S. (2010). A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Human molecular genetics, 19(24), 4948-4954. [ddq421]. https://doi.org/10.1093/hmg/ddq421
Yoon, Kyong Ah ; Park, Jae Hee ; Han, Jihye ; Park, Sohee ; Lee, Geon Kook ; Han, Ji Youn ; Zo, Jae Ill ; Kim, Jeongseon ; Lee, Jong Eun ; Takahashi, Atsushi ; Kubo, Michiaki ; Nakamura, Yusuke ; Lee, Jin Soo. / A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. In: Human molecular genetics. 2010 ; Vol. 19, No. 24. pp. 4948-4954.
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Yoon, KA, Park, JH, Han, J, Park, S, Lee, GK, Han, JY, Zo, JI, Kim, J, Lee, JE, Takahashi, A, Kubo, M, Nakamura, Y & Lee, JS 2010, 'A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population', Human molecular genetics, vol. 19, no. 24, ddq421, pp. 4948-4954. https://doi.org/10.1093/hmg/ddq421

A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. / Yoon, Kyong Ah; Park, Jae Hee; Han, Jihye; Park, Sohee; Lee, Geon Kook; Han, Ji Youn; Zo, Jae Ill; Kim, Jeongseon; Lee, Jong Eun; Takahashi, Atsushi; Kubo, Michiaki; Nakamura, Yusuke; Lee, Jin Soo.

In: Human molecular genetics, Vol. 19, No. 24, ddq421, 01.12.2010, p. 4948-4954.

Research output: Contribution to journalArticle

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AU - Yoon, Kyong Ah

AU - Park, Jae Hee

AU - Han, Jihye

AU - Park, Sohee

AU - Lee, Geon Kook

AU - Han, Ji Youn

AU - Zo, Jae Ill

AU - Kim, Jeongseon

AU - Lee, Jong Eun

AU - Takahashi, Atsushi

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Lee, Jin Soo

PY - 2010/12/1

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N2 - Lung cancer is one of the most common cancers and the major cause of cancer death, both in Korea and worldwide, with non-small cell lung cancer (NSCLC) as the predominant histologic type. To identify genetic risk factors, we here conducted a genome-wide association study (GWAS) and a replication study in 1425 patients with NSCLC and 3011 controls from Korea. From the data for 2162 participants analyzed using the Affymetrix Genome-wide Human SNP array 5.0K, 168 single nucleotide polymorphisms (SNPs) were selected for validation. In the second stage, we were able to genotype 168 SNPs in 804 patients and 1470 controls to confirm the results of the GWAS. In the meta-analysis, rs2131877 at the chromosome 3q29 region was the most significant biomarker of lung cancer susceptibility in Koreans (P = 2.43 × 10 -8 ). Four markers that were located within the chromosome 3q29 region were also associated with lung cancer susceptibility (trend P < 1.2 × 10 -4 ), along with markers on 5p15 that were previously reported in populations of European descent. This high-density large-scale GWAS carried out in the Korean population suggests that 3q29 is a novel susceptibility region associated with lung cancer susceptibility in Koreans.

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