A glioblastoma arising from the attached region where a meningioma had been totally removed

Shigeo Oba, Kazuhiko Shimizu, Syunsuke Shibao, Tomoru Miwa, Toru Nakagawa, Hikaru Sasaki, Hideki Murakami

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The co-occurrence of different histological tumors in the nervous system is rare and is mainly associated with phakomatoses or radiation exposure. A 72-year-old man underwent surgery for a frontal convexity meningioma. Four years after the surgery, a new lesion was detected in the attached region where the meningioma had been removed. The second tumor exhibited a high degree of cellularity, atypical mitosis, pseudo-palisading and microvascular proliferation, and was immunohistologically positive for GFAP and was diagnosed as a glioblastoma. Wild-type isocitrate dehydrogenase 1 was found in the second specimen. A genetic analysis using comparative genomic hybridization showed a DNA copy number loss on 1p35, 9pter-21, 10, 11q23, 13q, 14q, 20q, 22q and a gain on 7 in the second specimen. Although the mechanism responsible for the consecutive occurrence of meningioma and glioblastoma has not been elucidated, five hypotheses are feasible: (i) the lesions occurred incidentally; (ii) a low-grade astrocytoma present at the time of the first operation transformed into a high-grade glioma during the next 4 years; (iii) radiation received during the endovascular treatment induced glioblastoma; (iv) a brain scar created at the time of the first operation for meningioma led to the occurrence of a glioblastoma; and (v) the previous meningioma affected the surrounding glial cells, causing neoplastic transformation.

Original languageEnglish
Pages (from-to)606-611
Number of pages6
JournalNeuropathology
Volume31
Issue number6
DOIs
Publication statusPublished - 01-12-2011
Externally publishedYes

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Meningioma
Glioblastoma
Neurocutaneous Syndromes
Nervous System Neoplasms
Isocitrate Dehydrogenase
Comparative Genomic Hybridization
Astrocytoma
Mitosis
Glioma
Neuroglia
Cicatrix
Radiation
DNA
Brain
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Oba, Shigeo ; Shimizu, Kazuhiko ; Shibao, Syunsuke ; Miwa, Tomoru ; Nakagawa, Toru ; Sasaki, Hikaru ; Murakami, Hideki. / A glioblastoma arising from the attached region where a meningioma had been totally removed. In: Neuropathology. 2011 ; Vol. 31, No. 6. pp. 606-611.
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Oba, S, Shimizu, K, Shibao, S, Miwa, T, Nakagawa, T, Sasaki, H & Murakami, H 2011, 'A glioblastoma arising from the attached region where a meningioma had been totally removed', Neuropathology, vol. 31, no. 6, pp. 606-611. https://doi.org/10.1111/j.1440-1789.2011.01198.x

A glioblastoma arising from the attached region where a meningioma had been totally removed. / Oba, Shigeo; Shimizu, Kazuhiko; Shibao, Syunsuke; Miwa, Tomoru; Nakagawa, Toru; Sasaki, Hikaru; Murakami, Hideki.

In: Neuropathology, Vol. 31, No. 6, 01.12.2011, p. 606-611.

Research output: Contribution to journalArticle

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AU - Oba, Shigeo

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AU - Murakami, Hideki

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