Abstract
We report here a cDNA sequence of a murine homolog of the human major histocompatibility complex (MHC) class I-related gene, MR1. The analyses revealed unprecedentedly high conservation of MR1 in the α1 and α2 domains (corresponding to the peptide-binding domains in the classical MHC class I molecules) between human and mouse (predicted amino acid identity: 90 and 89% for the α1 and α2 domain, respectively), compared to MHC class I and other class I molecules. On the other hand, conservation in the α3 domain (73%) is comparable to those of others, suggesting domain-specific conservation of MR1. The localization of the mouse MR1 gene was determined to be chromosome 1H1, which corresponds to the human chromosomal region where the human MR1 gene is located (chromosome 1q25). High conservation of MR1 among mammals suggests that MR1 may be involved in critical conserved biological function(s).
| Original language | English |
|---|---|
| Pages (from-to) | 697-702 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 238 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 29-09-1997 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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A highly conserved major histocompatibility complex class I-related gene in mammals. / Yamaguchi, Hisateru; Hirai, Momoki; Kurosawa, Yoshikazu; Hashimoto, Keiichiro.
In: Biochemical and Biophysical Research Communications, Vol. 238, No. 3, 29.09.1997, p. 697-702.Research output: Contribution to journal › Article
TY - JOUR
T1 - A highly conserved major histocompatibility complex class I-related gene in mammals
AU - Yamaguchi, Hisateru
AU - Hirai, Momoki
AU - Kurosawa, Yoshikazu
AU - Hashimoto, Keiichiro
PY - 1997/9/29
Y1 - 1997/9/29
N2 - We report here a cDNA sequence of a murine homolog of the human major histocompatibility complex (MHC) class I-related gene, MR1. The analyses revealed unprecedentedly high conservation of MR1 in the α1 and α2 domains (corresponding to the peptide-binding domains in the classical MHC class I molecules) between human and mouse (predicted amino acid identity: 90 and 89% for the α1 and α2 domain, respectively), compared to MHC class I and other class I molecules. On the other hand, conservation in the α3 domain (73%) is comparable to those of others, suggesting domain-specific conservation of MR1. The localization of the mouse MR1 gene was determined to be chromosome 1H1, which corresponds to the human chromosomal region where the human MR1 gene is located (chromosome 1q25). High conservation of MR1 among mammals suggests that MR1 may be involved in critical conserved biological function(s).
AB - We report here a cDNA sequence of a murine homolog of the human major histocompatibility complex (MHC) class I-related gene, MR1. The analyses revealed unprecedentedly high conservation of MR1 in the α1 and α2 domains (corresponding to the peptide-binding domains in the classical MHC class I molecules) between human and mouse (predicted amino acid identity: 90 and 89% for the α1 and α2 domain, respectively), compared to MHC class I and other class I molecules. On the other hand, conservation in the α3 domain (73%) is comparable to those of others, suggesting domain-specific conservation of MR1. The localization of the mouse MR1 gene was determined to be chromosome 1H1, which corresponds to the human chromosomal region where the human MR1 gene is located (chromosome 1q25). High conservation of MR1 among mammals suggests that MR1 may be involved in critical conserved biological function(s).
UR - http://www.scopus.com/inward/record.url?scp=0031590256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031590256&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1997.7379
DO - 10.1006/bbrc.1997.7379
M3 - Article
C2 - 9325151
AN - SCOPUS:0031590256
VL - 238
SP - 697
EP - 702
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -