TY - JOUR
T1 - A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis
AU - Nishiyama, Yasuyuki
AU - Hirota, Toru
AU - Morisaki, Tetsuro
AU - Hara, Toshihiro
AU - Marumoto, Tomotoshi
AU - Iida, Shin Ichi
AU - Makino, Keishi
AU - Yamamoto, Hideyuki
AU - Hiraoka, Takehisa
AU - Kitamura, Nobuo
AU - Saya, Hideyuki
N1 - Funding Information:
We thank Drs. Q. Hu, and H. Maruta for providing the pCGN, and pGEX-2TH plasmids, respectively; Drs. H. Koga, N. Hanada, T. Tada, H. Nakamura and N. Mugita for valuable discussion; Dr. J. Moon for editing the manuscript; and T. Arino and K. Uriuda for secretarial assistance. This work was supported by Research Grant of the Princess Takamatsu Cancer Research Fund (#97-22906) and a grant for Cancer Research from the Ministry of Education, Science and Culture of Japan (H.S.).
PY - 1999/10/8
Y1 - 1999/10/8
N2 - We identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1. The h-warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis. Furthermore, h-warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase. These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.
AB - We identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1. The h-warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis. Furthermore, h-warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase. These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.
UR - https://www.scopus.com/pages/publications/0032863961
UR - https://www.scopus.com/pages/publications/0032863961#tab=citedBy
U2 - 10.1016/S0014-5793(99)01224-7
DO - 10.1016/S0014-5793(99)01224-7
M3 - Article
C2 - 10518011
AN - SCOPUS:0032863961
SN - 0014-5793
VL - 459
SP - 159
EP - 165
JO - FEBS Letters
JF - FEBS Letters
IS - 2
ER -