A hypoglycemia-inducing giant borderline phyllodes tumor secreting high-molecular-weight insulin-like growth factor II

Immunohistochemistry and a western blot analysis

Masahiro Hikichi, Yuka Kiriyama, Takanori Hayashi, Kaori Ushimado, Naomi Kobayashi, Makoto Urano, Makoto Kuroda, Toshiaki Utsumi

Research output: Contribution to journalArticle

Abstract

A 50-year-old woman with a large right breast mass was emergently hospitalized for generalized weakness and fatigue. A histological examination of tumor biopsy specimens revealed a phyllodes tumor (PT). She suddenly lost consciousness due to severe hypoglycemia. Non-islet cell tumor hypoglycemia (NICTH) due to the PT was suspected. The tumor was emergently resected. A histological examination revealed a borderline PT. The patient recovered from the hypoglycemic episode. High-molecular-weight insulin-like growth factor II was detected in serum that had been collected preoperatively and in the tumor tissue, but not in serum that had been collected postoperatively. We herein present a case of a borderline PT with NICTH.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalInternal Medicine
Volume57
Issue number2
DOIs
Publication statusPublished - 01-01-2018

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Phyllodes Tumor
Insulin-Like Growth Factor II
Hypoglycemia
Molecular Weight
Western Blotting
Immunohistochemistry
Neoplasms
Serum
Consciousness
Hypoglycemic Agents
Fatigue
Breast
Biopsy

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Hikichi, Masahiro ; Kiriyama, Yuka ; Hayashi, Takanori ; Ushimado, Kaori ; Kobayashi, Naomi ; Urano, Makoto ; Kuroda, Makoto ; Utsumi, Toshiaki. / A hypoglycemia-inducing giant borderline phyllodes tumor secreting high-molecular-weight insulin-like growth factor II : Immunohistochemistry and a western blot analysis. In: Internal Medicine. 2018 ; Vol. 57, No. 2. pp. 237-241.
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abstract = "A 50-year-old woman with a large right breast mass was emergently hospitalized for generalized weakness and fatigue. A histological examination of tumor biopsy specimens revealed a phyllodes tumor (PT). She suddenly lost consciousness due to severe hypoglycemia. Non-islet cell tumor hypoglycemia (NICTH) due to the PT was suspected. The tumor was emergently resected. A histological examination revealed a borderline PT. The patient recovered from the hypoglycemic episode. High-molecular-weight insulin-like growth factor II was detected in serum that had been collected preoperatively and in the tumor tissue, but not in serum that had been collected postoperatively. We herein present a case of a borderline PT with NICTH.",
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A hypoglycemia-inducing giant borderline phyllodes tumor secreting high-molecular-weight insulin-like growth factor II : Immunohistochemistry and a western blot analysis. / Hikichi, Masahiro; Kiriyama, Yuka; Hayashi, Takanori; Ushimado, Kaori; Kobayashi, Naomi; Urano, Makoto; Kuroda, Makoto; Utsumi, Toshiaki.

In: Internal Medicine, Vol. 57, No. 2, 01.01.2018, p. 237-241.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A hypoglycemia-inducing giant borderline phyllodes tumor secreting high-molecular-weight insulin-like growth factor II

T2 - Immunohistochemistry and a western blot analysis

AU - Hikichi, Masahiro

AU - Kiriyama, Yuka

AU - Hayashi, Takanori

AU - Ushimado, Kaori

AU - Kobayashi, Naomi

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AU - Kuroda, Makoto

AU - Utsumi, Toshiaki

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AB - A 50-year-old woman with a large right breast mass was emergently hospitalized for generalized weakness and fatigue. A histological examination of tumor biopsy specimens revealed a phyllodes tumor (PT). She suddenly lost consciousness due to severe hypoglycemia. Non-islet cell tumor hypoglycemia (NICTH) due to the PT was suspected. The tumor was emergently resected. A histological examination revealed a borderline PT. The patient recovered from the hypoglycemic episode. High-molecular-weight insulin-like growth factor II was detected in serum that had been collected preoperatively and in the tumor tissue, but not in serum that had been collected postoperatively. We herein present a case of a borderline PT with NICTH.

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