A Japanese multicenter survey characterizing pain in Parkinson's disease

Shin Ichiro Kubo, Shinsuke Hamada, Tetsuya Maeda, Tsuyoshi Uchiyama, Masaya Hashimoto, Nobuatsu Nomoto, Osamu Kano, Tatsuya Takahashi, Hiroo Terashi, Tetsuya Takahashi, Taku Hatano, Takafumi Hasegawa, Yasuhiko Baba, Renpei Sengoku, Hirohisa Watanabe, Taro Kadowaki, Manabu Inoue, Satoshi Kaneko, Hideki Shimura, Hiroshi Nagayama

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background Pain is a frequent, troublesome symptom of PD but is under-recognized and poorly understood. Aim We characterized pain prevalence, severity, and location in PD, to better understand its pathophysiology and improve diagnosis and treatment. Subjects and methods A cross-sectional controlled study was conducted at 19 centers across Japan. A total of 632 subjects with Mini-Mental State Examination scores ≥ 24 were enrolled, including 324 PD patients and 308 controls. Sex and mean age did not differ between the two groups. Demographic and clinical data were collected. Pain was assessed using questionnaires, the SF-36v2 bodily pain scale, and a body illustration for patients to indicate the location of pain in 45 anatomical areas. Results Pain prevalence in the PD group was 78.6%, significantly higher than in controls (49.0%), as was its severity. There was no correlation between SF-36v2 score and motor scores, such as Unified Parkinson's Disease Rating Scale III or Hoehn & Yahr scores. Pain distribution was similar between groups, predominantly in the lower back, followed by the gluteal region, lower legs, thighs, posterior neck, and shoulders. Conclusion Pain is a significant problem in the Japanese PD population and we discuss its pathophysiology.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalJournal of the Neurological Sciences
Publication statusPublished - 15-06-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'A Japanese multicenter survey characterizing pain in Parkinson's disease'. Together they form a unique fingerprint.

Cite this