TY - JOUR
T1 - A Japanese multicenter survey characterizing pain in Parkinson's disease
AU - Kubo, Shin Ichiro
AU - Hamada, Shinsuke
AU - Maeda, Tetsuya
AU - Uchiyama, Tsuyoshi
AU - Hashimoto, Masaya
AU - Nomoto, Nobuatsu
AU - Kano, Osamu
AU - Takahashi, Tatsuya
AU - Terashi, Hiroo
AU - Takahashi, Tetsuya
AU - Hatano, Taku
AU - Hasegawa, Takafumi
AU - Baba, Yasuhiko
AU - Sengoku, Renpei
AU - Watanabe, Hirohisa
AU - Kadowaki, Taro
AU - Inoue, Manabu
AU - Kaneko, Satoshi
AU - Shimura, Hideki
AU - Nagayama, Hiroshi
N1 - Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.
PY - 2016/6/15
Y1 - 2016/6/15
N2 - Background Pain is a frequent, troublesome symptom of PD but is under-recognized and poorly understood. Aim We characterized pain prevalence, severity, and location in PD, to better understand its pathophysiology and improve diagnosis and treatment. Subjects and methods A cross-sectional controlled study was conducted at 19 centers across Japan. A total of 632 subjects with Mini-Mental State Examination scores ≥ 24 were enrolled, including 324 PD patients and 308 controls. Sex and mean age did not differ between the two groups. Demographic and clinical data were collected. Pain was assessed using questionnaires, the SF-36v2 bodily pain scale, and a body illustration for patients to indicate the location of pain in 45 anatomical areas. Results Pain prevalence in the PD group was 78.6%, significantly higher than in controls (49.0%), as was its severity. There was no correlation between SF-36v2 score and motor scores, such as Unified Parkinson's Disease Rating Scale III or Hoehn & Yahr scores. Pain distribution was similar between groups, predominantly in the lower back, followed by the gluteal region, lower legs, thighs, posterior neck, and shoulders. Conclusion Pain is a significant problem in the Japanese PD population and we discuss its pathophysiology.
AB - Background Pain is a frequent, troublesome symptom of PD but is under-recognized and poorly understood. Aim We characterized pain prevalence, severity, and location in PD, to better understand its pathophysiology and improve diagnosis and treatment. Subjects and methods A cross-sectional controlled study was conducted at 19 centers across Japan. A total of 632 subjects with Mini-Mental State Examination scores ≥ 24 were enrolled, including 324 PD patients and 308 controls. Sex and mean age did not differ between the two groups. Demographic and clinical data were collected. Pain was assessed using questionnaires, the SF-36v2 bodily pain scale, and a body illustration for patients to indicate the location of pain in 45 anatomical areas. Results Pain prevalence in the PD group was 78.6%, significantly higher than in controls (49.0%), as was its severity. There was no correlation between SF-36v2 score and motor scores, such as Unified Parkinson's Disease Rating Scale III or Hoehn & Yahr scores. Pain distribution was similar between groups, predominantly in the lower back, followed by the gluteal region, lower legs, thighs, posterior neck, and shoulders. Conclusion Pain is a significant problem in the Japanese PD population and we discuss its pathophysiology.
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U2 - 10.1016/j.jns.2016.04.015
DO - 10.1016/j.jns.2016.04.015
M3 - Article
C2 - 27206899
AN - SCOPUS:84964344531
SN - 0022-510X
VL - 365
SP - 162
EP - 166
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -