A map for lineage restriction of progenitors during hematopoiesis: The essence of the myeloid-based model

Hiroshi Kawamoto, Tomokatsu Ikawa, Kyoko Masuda, Haruka Wada, Yoshimoto Katsura

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

Most hematology and immunology textbooks describe that the first branch point from the hematopoietic stem cells (HSCs) produces two progenitors, one for myelo-erythroid cells and the other for lymphoid cells including T and B cells. This model is based on the concept that the blood cell family can be subdivided into two major lineages, a myelo-erythroid lineage and a lymphoid lineage. Several alternative models have been proposed during the last three decades. We proposed the myeloid-based model in 2001, in which myeloid potential is retained in an early stage of branches toward erythroid, T-, and B-cell lineages. In this review, we focus on the point that cell differentiation models have two different facets: as a map of developmental potential and a cell fate map. These two are expressed in other words as a map for lineage restriction and a map for physiological production routes. We argue that a map of potential is first and foremost essential for the study of molecular mechanisms of lineage commitment, which is the least clarified aspect of cell differentiation. The validity of the myeloid-based model of hematopoiesis will be discussed in reference to these two issues, developmental potential and cell fate.

Original languageEnglish
Pages (from-to)23-36
Number of pages14
JournalImmunological Reviews
Volume238
Issue number1
DOIs
Publication statusPublished - 11-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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