A Method for Stabilizing the Proportion of the Reduced Form of Albumin During Cell-Free and Concentrated Ascites Reinfusion Therapy in Patients with Malignant Ascites

Atsushi Ohashi, Shigeru Nakai, Sachie Yamada, Masao Kato, Midori Hasegawa

Research output: Contribution to journalArticle

Abstract

Cell-free and concentrated ascites reinfusion therapy (CART) is used to treat malignant ascites. However, the qualities of albumin in malignant ascites, such as antioxidative activity, may decrease owing to oxidative stress caused by cancer cells and inflammatory reactions. We investigated the fraction percentages of mercaptalbumin (HMA%, reduced form) and non-mercaptalbumin (HNA%, oxidized form) in malignant ascites from 21 patients who received CART and compared the HMA% in the malignant ascites and human serum albumin (HSA) preparations. HMA% of albumin in malignant ascites (22.5%) was significantly lower than that in HSA preparation (42.2%). To ensure a high HMA%, we added L-cysteine to the paracentesis-treated ascites followed by dialysis 1 h later. As a result, the HMA% of albumin in malignant ascites was increased to 59.1%. Our results suggest that using this method in CART will improve patient's albumin quality.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Volume23
Issue number3
DOIs
Publication statusPublished - 06-2019

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All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

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