A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture

Kenichiro Takeshima, Yuji Nishiwaki, Yasunori Suda, Yasuo Niki, Yuiko Sato, Tami Kobayashi, Kana Miyamoto, Hisaya Uchida, Wataru Inokuchi, Takashi Tsuji, Atsushi Funayama, Masaya Nakamura, Morio Matsumoto, Yoshiaki Toyama, Takeshi Miyamoto

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5 Citations (Scopus)

Abstract

Hip fracture is the most severe bone fragility fracture among osteoporotic injuries. Family history is a known risk factor for fracture and now included among criteria for osteoporosis diagnosis and treatment; however, genetic factors underlying family history favoring fracture remain to be elucidated. Here we demonstrate that a missense SNP in the ALDH2 gene, rs671 (ALDH22), is significantly associated with hip fracture (odds ratio = 2.48, 95% confidence interval: 1.20-5.10, p = 0.021). The rs671 SNP was also significantly associated with osteoporosis development (odds ratio = 2.04, 95% confidence interval: 1.07-3.88, p = 0.040). For analysis we enrolled 92 hip fracture patients plus 48 control subjects without bone fragility fractures with higher than-2.5 SD bone mineral density. We also recruited 156 osteoporosis patients diagnosed as below-2.5 SD in terms of bone mineral density but without hip fracture. Association of rs671 with hip fracture and osteoporosis was significant even after adjustment for age and body mass index. Our results provide new insight into the pathogenesis of hip fracture.

Original languageEnglish
Article number428
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - 01-12-2017

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Hip Fractures
Single Nucleotide Polymorphism
Osteoporosis
Genes
Bone Fractures
Bone Density
Odds Ratio
Confidence Intervals
Body Mass Index
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • General

Cite this

Takeshima, K., Nishiwaki, Y., Suda, Y., Niki, Y., Sato, Y., Kobayashi, T., ... Miyamoto, T. (2017). A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture. Scientific reports, 7(1), [428]. https://doi.org/10.1038/s41598-017-00503-2
Takeshima, Kenichiro ; Nishiwaki, Yuji ; Suda, Yasunori ; Niki, Yasuo ; Sato, Yuiko ; Kobayashi, Tami ; Miyamoto, Kana ; Uchida, Hisaya ; Inokuchi, Wataru ; Tsuji, Takashi ; Funayama, Atsushi ; Nakamura, Masaya ; Matsumoto, Morio ; Toyama, Yoshiaki ; Miyamoto, Takeshi. / A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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abstract = "Hip fracture is the most severe bone fragility fracture among osteoporotic injuries. Family history is a known risk factor for fracture and now included among criteria for osteoporosis diagnosis and treatment; however, genetic factors underlying family history favoring fracture remain to be elucidated. Here we demonstrate that a missense SNP in the ALDH2 gene, rs671 (ALDH22), is significantly associated with hip fracture (odds ratio = 2.48, 95{\%} confidence interval: 1.20-5.10, p = 0.021). The rs671 SNP was also significantly associated with osteoporosis development (odds ratio = 2.04, 95{\%} confidence interval: 1.07-3.88, p = 0.040). For analysis we enrolled 92 hip fracture patients plus 48 control subjects without bone fragility fractures with higher than-2.5 SD bone mineral density. We also recruited 156 osteoporosis patients diagnosed as below-2.5 SD in terms of bone mineral density but without hip fracture. Association of rs671 with hip fracture and osteoporosis was significant even after adjustment for age and body mass index. Our results provide new insight into the pathogenesis of hip fracture.",
author = "Kenichiro Takeshima and Yuji Nishiwaki and Yasunori Suda and Yasuo Niki and Yuiko Sato and Tami Kobayashi and Kana Miyamoto and Hisaya Uchida and Wataru Inokuchi and Takashi Tsuji and Atsushi Funayama and Masaya Nakamura and Morio Matsumoto and Yoshiaki Toyama and Takeshi Miyamoto",
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Takeshima, K, Nishiwaki, Y, Suda, Y, Niki, Y, Sato, Y, Kobayashi, T, Miyamoto, K, Uchida, H, Inokuchi, W, Tsuji, T, Funayama, A, Nakamura, M, Matsumoto, M, Toyama, Y & Miyamoto, T 2017, 'A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture', Scientific reports, vol. 7, no. 1, 428. https://doi.org/10.1038/s41598-017-00503-2

A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture. / Takeshima, Kenichiro; Nishiwaki, Yuji; Suda, Yasunori; Niki, Yasuo; Sato, Yuiko; Kobayashi, Tami; Miyamoto, Kana; Uchida, Hisaya; Inokuchi, Wataru; Tsuji, Takashi; Funayama, Atsushi; Nakamura, Masaya; Matsumoto, Morio; Toyama, Yoshiaki; Miyamoto, Takeshi.

In: Scientific reports, Vol. 7, No. 1, 428, 01.12.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture

AU - Takeshima, Kenichiro

AU - Nishiwaki, Yuji

AU - Suda, Yasunori

AU - Niki, Yasuo

AU - Sato, Yuiko

AU - Kobayashi, Tami

AU - Miyamoto, Kana

AU - Uchida, Hisaya

AU - Inokuchi, Wataru

AU - Tsuji, Takashi

AU - Funayama, Atsushi

AU - Nakamura, Masaya

AU - Matsumoto, Morio

AU - Toyama, Yoshiaki

AU - Miyamoto, Takeshi

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Hip fracture is the most severe bone fragility fracture among osteoporotic injuries. Family history is a known risk factor for fracture and now included among criteria for osteoporosis diagnosis and treatment; however, genetic factors underlying family history favoring fracture remain to be elucidated. Here we demonstrate that a missense SNP in the ALDH2 gene, rs671 (ALDH22), is significantly associated with hip fracture (odds ratio = 2.48, 95% confidence interval: 1.20-5.10, p = 0.021). The rs671 SNP was also significantly associated with osteoporosis development (odds ratio = 2.04, 95% confidence interval: 1.07-3.88, p = 0.040). For analysis we enrolled 92 hip fracture patients plus 48 control subjects without bone fragility fractures with higher than-2.5 SD bone mineral density. We also recruited 156 osteoporosis patients diagnosed as below-2.5 SD in terms of bone mineral density but without hip fracture. Association of rs671 with hip fracture and osteoporosis was significant even after adjustment for age and body mass index. Our results provide new insight into the pathogenesis of hip fracture.

AB - Hip fracture is the most severe bone fragility fracture among osteoporotic injuries. Family history is a known risk factor for fracture and now included among criteria for osteoporosis diagnosis and treatment; however, genetic factors underlying family history favoring fracture remain to be elucidated. Here we demonstrate that a missense SNP in the ALDH2 gene, rs671 (ALDH22), is significantly associated with hip fracture (odds ratio = 2.48, 95% confidence interval: 1.20-5.10, p = 0.021). The rs671 SNP was also significantly associated with osteoporosis development (odds ratio = 2.04, 95% confidence interval: 1.07-3.88, p = 0.040). For analysis we enrolled 92 hip fracture patients plus 48 control subjects without bone fragility fractures with higher than-2.5 SD bone mineral density. We also recruited 156 osteoporosis patients diagnosed as below-2.5 SD in terms of bone mineral density but without hip fracture. Association of rs671 with hip fracture and osteoporosis was significant even after adjustment for age and body mass index. Our results provide new insight into the pathogenesis of hip fracture.

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