A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography

Hidehiro Iida, Tooru Akutsu, Keigo Endo, Hiroshi Fukuda, Takeshi Inoue, Hiroshi Ito, Sukehiko Koga, Akio Komatani, Yasuo Kuwabara, Toshimitsu Momose, Sadahiko Nishizawa, Ikuo Odano, Masaki Ohkubo, Yasuhito Sasaki, Hideki Suzuki, Shuuji Tanada, Hiroshi Toyama, Yoshiharu Yonekura, Tsuyoshi Yoshida, Kazuo Uemura

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Recently, two methods have been proposed for regional cerebral blood flow (rCBF) quantitation using [123I]iodoamphetamine (IMP) and single- photon emission computed tomography (SPECT). The table look-up (TLU) method has been shown to provide both rCBF and volume of distribution. V(d), images from two SPECT scans, while a single-scan autoradiographic (ARG) technique provided rCBF using a fixed and assumed V(d). In both methods, a single blood sample was referred to calibrate the previously determined standard input function. The present multicenter project was designed to evaluate the accuracy of both methods for use as clinical investigative tools. Ten independent institutions performed [123I]IMP-SPECT studies according to both methods in 76 subjects (10 normal volunteers, 32 patients with cerebrovascular disease, and 34 patients with other diseases). Calculated rCBF values were compared with those obtained by the following reference methods available in the participating institutions: [15O] H2O positron emission tomography (PET) (five institutions), [133Xe] SPECT (four institutions), and the [123I]IMP microsphere method (three institutions). Both ARG and TLU methods provided rCBF values that were significantly correlated with those measured by the [15O] H2O PET technique (p < 0.001 for all subjects: overall regression equation, y = 15.14 + 0.54x) and those measured by the [123I]IMP-microsphere method (p < 0.001 for all subjects: y = 2.0 + 0.80x). Significant correlation (p < 0.05) was observed in 18 of 24 subjects studied with the [133Xe] SPECT reference technique (overall regression equation, y = 15.0 + 0.55x). Mean cortical gray matter rCBF in a group of normal subject was 43.9 ± 3.3 and 43.4 ± 2.0 mol/min/100 g for the ARG and TLU methods, respectively. Regional V(d) of [123I]IMP estimated by the TLU method was 45 ml/ml ± 20% in the normal cortical region. Close agreement between ARG and TLU rCBF values was observed (y = -3.21 + 1.07x, r = 0.97), confirming the validity of assuming a fixed V(d) in the ARG method. Results of this study demonstrate that both the ARG and TLU methods accurately and reliably estimate rCBF in a variety of clinical settings.

Original languageEnglish
Pages (from-to)781-793
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Volume16
Issue number5
DOIs
Publication statusPublished - 01-01-1996

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Single-Photon Emission-Computed Tomography
Microspheres
Positron-Emission Tomography
Cerebrovascular Disorders

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Iida, Hidehiro ; Akutsu, Tooru ; Endo, Keigo ; Fukuda, Hiroshi ; Inoue, Takeshi ; Ito, Hiroshi ; Koga, Sukehiko ; Komatani, Akio ; Kuwabara, Yasuo ; Momose, Toshimitsu ; Nishizawa, Sadahiko ; Odano, Ikuo ; Ohkubo, Masaki ; Sasaki, Yasuhito ; Suzuki, Hideki ; Tanada, Shuuji ; Toyama, Hiroshi ; Yonekura, Yoshiharu ; Yoshida, Tsuyoshi ; Uemura, Kazuo. / A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography. In: Journal of Cerebral Blood Flow and Metabolism. 1996 ; Vol. 16, No. 5. pp. 781-793.
@article{5e07bf2860614fb2a283b43185c629bc,
title = "A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography",
abstract = "Recently, two methods have been proposed for regional cerebral blood flow (rCBF) quantitation using [123I]iodoamphetamine (IMP) and single- photon emission computed tomography (SPECT). The table look-up (TLU) method has been shown to provide both rCBF and volume of distribution. V(d), images from two SPECT scans, while a single-scan autoradiographic (ARG) technique provided rCBF using a fixed and assumed V(d). In both methods, a single blood sample was referred to calibrate the previously determined standard input function. The present multicenter project was designed to evaluate the accuracy of both methods for use as clinical investigative tools. Ten independent institutions performed [123I]IMP-SPECT studies according to both methods in 76 subjects (10 normal volunteers, 32 patients with cerebrovascular disease, and 34 patients with other diseases). Calculated rCBF values were compared with those obtained by the following reference methods available in the participating institutions: [15O] H2O positron emission tomography (PET) (five institutions), [133Xe] SPECT (four institutions), and the [123I]IMP microsphere method (three institutions). Both ARG and TLU methods provided rCBF values that were significantly correlated with those measured by the [15O] H2O PET technique (p < 0.001 for all subjects: overall regression equation, y = 15.14 + 0.54x) and those measured by the [123I]IMP-microsphere method (p < 0.001 for all subjects: y = 2.0 + 0.80x). Significant correlation (p < 0.05) was observed in 18 of 24 subjects studied with the [133Xe] SPECT reference technique (overall regression equation, y = 15.0 + 0.55x). Mean cortical gray matter rCBF in a group of normal subject was 43.9 ± 3.3 and 43.4 ± 2.0 mol/min/100 g for the ARG and TLU methods, respectively. Regional V(d) of [123I]IMP estimated by the TLU method was 45 ml/ml ± 20{\%} in the normal cortical region. Close agreement between ARG and TLU rCBF values was observed (y = -3.21 + 1.07x, r = 0.97), confirming the validity of assuming a fixed V(d) in the ARG method. Results of this study demonstrate that both the ARG and TLU methods accurately and reliably estimate rCBF in a variety of clinical settings.",
author = "Hidehiro Iida and Tooru Akutsu and Keigo Endo and Hiroshi Fukuda and Takeshi Inoue and Hiroshi Ito and Sukehiko Koga and Akio Komatani and Yasuo Kuwabara and Toshimitsu Momose and Sadahiko Nishizawa and Ikuo Odano and Masaki Ohkubo and Yasuhito Sasaki and Hideki Suzuki and Shuuji Tanada and Hiroshi Toyama and Yoshiharu Yonekura and Tsuyoshi Yoshida and Kazuo Uemura",
year = "1996",
month = "1",
day = "1",
doi = "10.1097/00004647-199609000-00003",
language = "English",
volume = "16",
pages = "781--793",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "5",

}

Iida, H, Akutsu, T, Endo, K, Fukuda, H, Inoue, T, Ito, H, Koga, S, Komatani, A, Kuwabara, Y, Momose, T, Nishizawa, S, Odano, I, Ohkubo, M, Sasaki, Y, Suzuki, H, Tanada, S, Toyama, H, Yonekura, Y, Yoshida, T & Uemura, K 1996, 'A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography', Journal of Cerebral Blood Flow and Metabolism, vol. 16, no. 5, pp. 781-793. https://doi.org/10.1097/00004647-199609000-00003

A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography. / Iida, Hidehiro; Akutsu, Tooru; Endo, Keigo; Fukuda, Hiroshi; Inoue, Takeshi; Ito, Hiroshi; Koga, Sukehiko; Komatani, Akio; Kuwabara, Yasuo; Momose, Toshimitsu; Nishizawa, Sadahiko; Odano, Ikuo; Ohkubo, Masaki; Sasaki, Yasuhito; Suzuki, Hideki; Tanada, Shuuji; Toyama, Hiroshi; Yonekura, Yoshiharu; Yoshida, Tsuyoshi; Uemura, Kazuo.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 16, No. 5, 01.01.1996, p. 781-793.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography

AU - Iida, Hidehiro

AU - Akutsu, Tooru

AU - Endo, Keigo

AU - Fukuda, Hiroshi

AU - Inoue, Takeshi

AU - Ito, Hiroshi

AU - Koga, Sukehiko

AU - Komatani, Akio

AU - Kuwabara, Yasuo

AU - Momose, Toshimitsu

AU - Nishizawa, Sadahiko

AU - Odano, Ikuo

AU - Ohkubo, Masaki

AU - Sasaki, Yasuhito

AU - Suzuki, Hideki

AU - Tanada, Shuuji

AU - Toyama, Hiroshi

AU - Yonekura, Yoshiharu

AU - Yoshida, Tsuyoshi

AU - Uemura, Kazuo

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Recently, two methods have been proposed for regional cerebral blood flow (rCBF) quantitation using [123I]iodoamphetamine (IMP) and single- photon emission computed tomography (SPECT). The table look-up (TLU) method has been shown to provide both rCBF and volume of distribution. V(d), images from two SPECT scans, while a single-scan autoradiographic (ARG) technique provided rCBF using a fixed and assumed V(d). In both methods, a single blood sample was referred to calibrate the previously determined standard input function. The present multicenter project was designed to evaluate the accuracy of both methods for use as clinical investigative tools. Ten independent institutions performed [123I]IMP-SPECT studies according to both methods in 76 subjects (10 normal volunteers, 32 patients with cerebrovascular disease, and 34 patients with other diseases). Calculated rCBF values were compared with those obtained by the following reference methods available in the participating institutions: [15O] H2O positron emission tomography (PET) (five institutions), [133Xe] SPECT (four institutions), and the [123I]IMP microsphere method (three institutions). Both ARG and TLU methods provided rCBF values that were significantly correlated with those measured by the [15O] H2O PET technique (p < 0.001 for all subjects: overall regression equation, y = 15.14 + 0.54x) and those measured by the [123I]IMP-microsphere method (p < 0.001 for all subjects: y = 2.0 + 0.80x). Significant correlation (p < 0.05) was observed in 18 of 24 subjects studied with the [133Xe] SPECT reference technique (overall regression equation, y = 15.0 + 0.55x). Mean cortical gray matter rCBF in a group of normal subject was 43.9 ± 3.3 and 43.4 ± 2.0 mol/min/100 g for the ARG and TLU methods, respectively. Regional V(d) of [123I]IMP estimated by the TLU method was 45 ml/ml ± 20% in the normal cortical region. Close agreement between ARG and TLU rCBF values was observed (y = -3.21 + 1.07x, r = 0.97), confirming the validity of assuming a fixed V(d) in the ARG method. Results of this study demonstrate that both the ARG and TLU methods accurately and reliably estimate rCBF in a variety of clinical settings.

AB - Recently, two methods have been proposed for regional cerebral blood flow (rCBF) quantitation using [123I]iodoamphetamine (IMP) and single- photon emission computed tomography (SPECT). The table look-up (TLU) method has been shown to provide both rCBF and volume of distribution. V(d), images from two SPECT scans, while a single-scan autoradiographic (ARG) technique provided rCBF using a fixed and assumed V(d). In both methods, a single blood sample was referred to calibrate the previously determined standard input function. The present multicenter project was designed to evaluate the accuracy of both methods for use as clinical investigative tools. Ten independent institutions performed [123I]IMP-SPECT studies according to both methods in 76 subjects (10 normal volunteers, 32 patients with cerebrovascular disease, and 34 patients with other diseases). Calculated rCBF values were compared with those obtained by the following reference methods available in the participating institutions: [15O] H2O positron emission tomography (PET) (five institutions), [133Xe] SPECT (four institutions), and the [123I]IMP microsphere method (three institutions). Both ARG and TLU methods provided rCBF values that were significantly correlated with those measured by the [15O] H2O PET technique (p < 0.001 for all subjects: overall regression equation, y = 15.14 + 0.54x) and those measured by the [123I]IMP-microsphere method (p < 0.001 for all subjects: y = 2.0 + 0.80x). Significant correlation (p < 0.05) was observed in 18 of 24 subjects studied with the [133Xe] SPECT reference technique (overall regression equation, y = 15.0 + 0.55x). Mean cortical gray matter rCBF in a group of normal subject was 43.9 ± 3.3 and 43.4 ± 2.0 mol/min/100 g for the ARG and TLU methods, respectively. Regional V(d) of [123I]IMP estimated by the TLU method was 45 ml/ml ± 20% in the normal cortical region. Close agreement between ARG and TLU rCBF values was observed (y = -3.21 + 1.07x, r = 0.97), confirming the validity of assuming a fixed V(d) in the ARG method. Results of this study demonstrate that both the ARG and TLU methods accurately and reliably estimate rCBF in a variety of clinical settings.

UR - http://www.scopus.com/inward/record.url?scp=19244362116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19244362116&partnerID=8YFLogxK

U2 - 10.1097/00004647-199609000-00003

DO - 10.1097/00004647-199609000-00003

M3 - Article

C2 - 8784223

AN - SCOPUS:19244362116

VL - 16

SP - 781

EP - 793

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 5

ER -