A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3

Truong Minh Pham, Yoshihisa Fujino, Shogo Kikuchi, Akiko Tamakoshi, Hiroshi Yatsuya, Shinya Matsuda, Takesumi Yoshimura

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We conducted this study to investigate the association between serum levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF-binding protein (IGFBP)-3 and the incidence of stomach cancer. A nested case-control study of 161 stomach cancer incidences and 314 matched controls was established within the Japan Collaborative Cohort Study. The adjusted ORs for IGF-1 quartile ranged from 0.84 and 1.13, but these were not statistically significant. Further, higher IGF-2 levels did not significantly correlate with the incidence of stomach cancer. A tendency for the risk of stomach cancer to decrease with increasing IGFBP-3 level was observed, but without statistical significance. A slight decrease in risk was seen with an increase in IGFBP-3 level, but neither change was statistically significant. To conclude, we found no association between IGF-1, IGF-2, or IGFBP-3 serum levels and the risk of stomach cancer. As this association has not been established, these findings need to be confirmed in future studies.

Original languageEnglish
Pages (from-to)1611-1616
Number of pages6
JournalEuropean Journal of Cancer
Volume43
Issue number10
DOIs
Publication statusPublished - 01-07-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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