A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3

Truong Minh Pham, Yoshihisa Fujino, Shogo Kikuchi, Akiko Tamakoshi, Hiroshi Yatsuya, Shinya Matsuda, Takesumi Yoshimura

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We conducted this study to investigate the association between serum levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF-binding protein (IGFBP)-3 and the incidence of stomach cancer. A nested case-control study of 161 stomach cancer incidences and 314 matched controls was established within the Japan Collaborative Cohort Study. The adjusted ORs for IGF-1 quartile ranged from 0.84 and 1.13, but these were not statistically significant. Further, higher IGF-2 levels did not significantly correlate with the incidence of stomach cancer. A tendency for the risk of stomach cancer to decrease with increasing IGFBP-3 level was observed, but without statistical significance. A slight decrease in risk was seen with an increase in IGFBP-3 level, but neither change was statistically significant. To conclude, we found no association between IGF-1, IGF-2, or IGFBP-3 serum levels and the risk of stomach cancer. As this association has not been established, these findings need to be confirmed in future studies.

Original languageEnglish
Pages (from-to)1611-1616
Number of pages6
JournalEuropean Journal of Cancer
Volume43
Issue number10
DOIs
Publication statusPublished - 01-07-2007
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor Binding Protein 3
Somatomedins
Stomach Neoplasms
Case-Control Studies
Serum
Incidence
Japan
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Pham, Truong Minh ; Fujino, Yoshihisa ; Kikuchi, Shogo ; Tamakoshi, Akiko ; Yatsuya, Hiroshi ; Matsuda, Shinya ; Yoshimura, Takesumi. / A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. In: European Journal of Cancer. 2007 ; Vol. 43, No. 10. pp. 1611-1616.
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A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. / Pham, Truong Minh; Fujino, Yoshihisa; Kikuchi, Shogo; Tamakoshi, Akiko; Yatsuya, Hiroshi; Matsuda, Shinya; Yoshimura, Takesumi.

In: European Journal of Cancer, Vol. 43, No. 10, 01.07.2007, p. 1611-1616.

Research output: Contribution to journalArticle

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AU - Pham, Truong Minh

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AU - Kikuchi, Shogo

AU - Tamakoshi, Akiko

AU - Yatsuya, Hiroshi

AU - Matsuda, Shinya

AU - Yoshimura, Takesumi

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