TY - JOUR
T1 - A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3
AU - Pham, Truong Minh
AU - Fujino, Yoshihisa
AU - Kikuchi, Shogo
AU - Tamakoshi, Akiko
AU - Yatsuya, Hiroshi
AU - Matsuda, Shinya
AU - Yoshimura, Takesumi
N1 - Funding Information:
The authors express their sincere appreciation to Dr. Kunio Aoki, Professor Emeritus, Nagoya University School of Medicine and the former chairman of the JACC Study; Dr. Haruo Sugano, former Director of the Cancer Institute, Tokyo, who greatly contributed to the initiation of the JACC Study; and Dr. Yoshiyuki Ohno, Professor Emeritus, Nagoya University School of Medicine, who was the past chairman of the study. The authors also wish to thank Dr. Tomoyuki Kitagawa, Cancer Institute of the Japanese Foundation for Cancer Research and former chairman of the Grant-in-Aid for Scientific Research on Priority Area ’Cancer’, for his full support of this study.
Funding Information:
Grants: This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (2) (No. 12218237) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. The JACC Study was also supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (Monbusho) (Nos. 61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, and 11181101).
PY - 2007/7
Y1 - 2007/7
N2 - We conducted this study to investigate the association between serum levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF-binding protein (IGFBP)-3 and the incidence of stomach cancer. A nested case-control study of 161 stomach cancer incidences and 314 matched controls was established within the Japan Collaborative Cohort Study. The adjusted ORs for IGF-1 quartile ranged from 0.84 and 1.13, but these were not statistically significant. Further, higher IGF-2 levels did not significantly correlate with the incidence of stomach cancer. A tendency for the risk of stomach cancer to decrease with increasing IGFBP-3 level was observed, but without statistical significance. A slight decrease in risk was seen with an increase in IGFBP-3 level, but neither change was statistically significant. To conclude, we found no association between IGF-1, IGF-2, or IGFBP-3 serum levels and the risk of stomach cancer. As this association has not been established, these findings need to be confirmed in future studies.
AB - We conducted this study to investigate the association between serum levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF-binding protein (IGFBP)-3 and the incidence of stomach cancer. A nested case-control study of 161 stomach cancer incidences and 314 matched controls was established within the Japan Collaborative Cohort Study. The adjusted ORs for IGF-1 quartile ranged from 0.84 and 1.13, but these were not statistically significant. Further, higher IGF-2 levels did not significantly correlate with the incidence of stomach cancer. A tendency for the risk of stomach cancer to decrease with increasing IGFBP-3 level was observed, but without statistical significance. A slight decrease in risk was seen with an increase in IGFBP-3 level, but neither change was statistically significant. To conclude, we found no association between IGF-1, IGF-2, or IGFBP-3 serum levels and the risk of stomach cancer. As this association has not been established, these findings need to be confirmed in future studies.
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U2 - 10.1016/j.ejca.2007.04.014
DO - 10.1016/j.ejca.2007.04.014
M3 - Article
C2 - 17532620
AN - SCOPUS:34250190242
SN - 0959-8049
VL - 43
SP - 1611
EP - 1616
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 10
ER -
